HIV pills show more promise to prevent infection

Updated 23 July 2014
0

HIV pills show more promise to prevent infection

MELBOURNE: There is more good news about HIV treatment pills used to prevent infection in people at high risk of getting the AIDS virus: Follow-up from a landmark study that proved the drug works now shows that it does not encourage risky sex and is effective even if people skip some doses.
The research was discussed Tuesday at the International AIDS Conference in Melbourne, Australia, and was published by the British journal Lancet Infectious Diseases.
It involves 1,600 gay men and transgender women who took part in the original study showing that daily use of the drug Truvada lowered the risk of getting HIV.
After the study ended, they were offered the chance to keep getting the pills for free, and three-quarters of them agreed. All were studied for another 17 months.
None who took the pills at least four days a week became infected. Even use two or three days a week lowered the risk of infection compared to taking the pills less often or not at all. Researchers could tell how often the drug was taken because they measured it in blood samples.
“We’re encouraged,” said study leader Dr. Robert Grant, an AIDS expert at the Gladstone Institutes, a foundation affiliated with the University of California, San Francisco. “There’s a demand, there’s some forgiveness for missed doses. And it’s safe.” Mitchell Warren, who heads a nonprofit group that works on HIV prevention research, said in an e-mail from Melbourne that “the story is now clear” that this approach “is real, it works, and it should be made available to people at risk now as part of high-impact combination prevention.” Condoms remain the best way to prevent HIV infection but not everyone uses them all the time, so health officials recommend other options for certain groups, such as gay men.
Some health officials had worried that taking Truvada might give a false sense of security and make men less likely to use condoms or to limit their partners. However, study participants reported no increase in these behaviors, and there was no rise in syphilis or herpes, other sexually spread diseases that might suggest risk-taking.
The study was done in the United States, South America, Africa and Thailand, and paid for by the US National Institutes of Health.
Truvada already is sold for treating HIV. It’s a combination of two drugs, tenofovir and emtricitabine, or FTC, made by California-based Gilead Sciences Inc. Its wholesale price is $800 a month in the US but generic versions are available in other countries and they cost as little as 31 cents a day in Africa, Grant said.
“The main challenge is to find a way to make it more available,” he said.


Trump declares emergency for US-Mexico border wall, House panel launches probe

Updated 16 February 2019
0

Trump declares emergency for US-Mexico border wall, House panel launches probe

  • The Republican president’s move, circumventing Congress, seeks to make good on a 2016 presidential campaign pledge to build a border wall
  • Within hours, the action was challenged in a lawsuit filed on behalf of three Texas landowners

WASHINGTON: President Donald Trump on Friday declared a national emergency in a bid to fund his promised wall at the US-Mexico border without congressional approval, an action Democrats vowed to challenge as a violation of the US Constitution.

The Republican president’s move, circumventing Congress, seeks to make good on a 2016 presidential campaign pledge to build a border wall that Trump insists is necessary to curtail illegal immigration he blames for bringing crime and drugs into the United States.

Within hours, the action was challenged in a lawsuit filed on behalf of three Texas landowners, saying that Trump’s declaration violates the US Constitution and that the planned wall would infringe on their property rights.

Both California and New York said that they, too, planned to file lawsuits.

Hours after Trump’s announcement, the Democratic-controlled House of Representatives’ Judiciary Committee said it had launched an investigation into the emergency declaration.

In a letter to Trump, committee Democrats asked him to make available for a hearing White House and Justice Department officials involved in the action. They also requested legal documents on the decision that led to the declaration, setting a deadline of next Friday.

“We believe your declaration of an emergency shows a reckless disregard for the separation of powers and your own responsibilities under our constitutional system,” said the letter, signed by Chairman Jerrold Nadler and other top Democrats on the panel.

Trump has been demanding for a wall on the 2,000-mile (3,200-kilometer) southern border

Trump on Friday also signed a bipartisan government spending bill that would prevent another partial government shutdown by funding several agencies that otherwise would have closed on Saturday.

The funding bill represented a legislative defeat for him since it contains no money for his proposed wall — the focus of weeks of conflict between Trump and Democrats in Congress.

Trump made no mention of the bill in rambling comments to reporters in the White House’s Rose Garden.

He had demanded that Congress provide him with $5.7 billion in wall funding as part of legislation to fund the agencies. That triggered a historic, 35-day government shutdown in December and January that hurt the US economy and his opinion poll numbers.

By reorienting his quest for wall funding toward a legally uncertain strategy based on declaring a national emergency, Trump risks plunging into a lengthy legislative and legal battle with Democrats and dividing his fellow Republicans — many of whom expressed grave reservations on Friday about the president’s action.

Fifteen Democrats in the Republican-controlled Senate introduced legislation on Thursday to prevent Trump from invoking emergency powers to transfer funds to his wall from accounts Congress has already committed to other projects.

Nancy Pelosi, the Democratic speaker of the House, and top Senate Democrat Chuck Schumer swiftly responded to Trump’s declaration.

“The president’s actions clearly violate the Congress’s exclusive power of the purse, which our Founders enshrined in the Constitution,” they said in a statement. “The Congress will defend our constitutional authorities in the Congress, in the courts, and in the public, using every remedy available.”

Members of the migrant caravan that has made its way from central America to the US-Mexico border

The first legal challenge, filed in federal court in Washington, came from three Texas landowners along the Rio Grande river claiming they were informed the US government would seek to build a border wall on their properties if money for the project were available in 2019.

The lawsuit, filed on their behalf by the consumer advocacy group Public Citizen, also named the Frontera Audubon Society as a plaintiff whose “members’ ability to observe wildlife will be impaired” by construction of a border wall and resulting habitat damage.

The suit contests Trump’s assertion of a national emergency at the border to justify the president’s action.

California Governor Gavin Newsom, a Democrat, describing the supposed border crisis touted by Trump as “made-up,” and New York state’s Democratic attorney general, Letitia James, both said they planned to challenge Trump in court.

Trump acknowledged his order would face a lengthy court fight.

“I expect to be sued. I shouldn’t be sued. ... We’ll win in the Supreme Court,” he predicted.

Trump may have also undermined his administration’s argument about the urgency of the situation when he told reporters, “I didn’t need to do this. But I’d rather do it much faster.”

In their letter to Trump, House Judiciary Democrats said that language had left them “troubled.”

Both the House and the Senate could pass a resolution terminating the emergency by majority vote. However, any such measure would then go to Trump, who would likely veto it. Overriding the veto would require a two-thirds vote in both chambers.

Although Trump says a wall is needed to curb illegal immigrants and illicit drugs coming across the border, statistics show that illegal immigration via the border is at a 20-year low and that many drug shipments come through legal ports of entry.

Confronted with those statistics by reporters at the Rose Garden event, Trump said they were “wrong.”

Also present were a half-dozen women holding poster-sized pictures of family members killed by illegal immigrants. Trump noted their presence in announcing the emergency declaration.

He estimated his emergency declaration could free up as much as $8 billion to pay for part of the wall. Estimates of its total cost run as high as $23 billion.

As a candidate, Trump repeatedly promised Mexico would pay for the wall. It was one of his biggest applause lines at his campaign rallies. Mexico firmly refused to pay, and now Trump wants US taxpayers to cover the costs.