Netanyahu along with Israeli security officials have repeatedly expressed concern over what they see as Iran moving to expand its presence in the Middle East.
Netanyahu will neet Putin at the Black Sea resort city of Sochi on Wednesday. Both Russia and Iran back Syrian President Bashar Assad’s regime in the war.
“I will raise the problem of Iran trying to establish a military presence in Syria,” Netanyahu said in a statement on Tuesday.
“This proves that Iran’s aggression has not diminished since the nuclear agreement, which has become a problem not only for Israel, but for all the countries of the Middle East and the entire world.”
The head of Israeli spy agency Mossad, Yossi Cohen, and Netanyahu’s newly named head of his national security council, Meir Ben-Shabbat, will join him on the trip.
Netanyahu opposes a southwest Syria cease-fire recently agreed by Russia and the US because he believes it would enable Iran to solidify its presence in the country, an Israeli official has said.
An Israeli intelligence official said in April his country fears an “Iranian crescent” may be forming in the Middle East because of Tehran’s influence in Syria and its connections with regional Shiite groups.
Beyond concerns over Iran, Netanyahu’s talks with Putin are also likely to involve coordination in Syria.
Russia and Israel have established a “hotline” to avoid accidental clashes in the country.
Israel has sought to avoid being dragged into the six-year Syrian conflict, but has acknowledged carrying out strikes to stop advanced weapons deliveries to Hezbollah, the Lebanese group with which it fought a devastating war in 2006.
Hezbollah also backs Assad’s regime in the Syrian war.