The officials say the strike took place on Wednesday and targeted a compound frequented by Mullah Fazlullah, the leader of the Pakistani Taliban who is believed to be hiding in Afghanistan.
They say Fazlullah was apparently not there but his son was killed.
The officials say the strike occurred in Afghanistan’s Kunar province, miles away from Pakistani border.
Three Pakistani Taliban commanders also confirmed the strike and militant casualties.
Pakistani officials and the Taliban commanders spoke on condition of anonymity as they weren’t authorized to speak to reporters. The US made no comment on the strike.