Japan to trial ‘world’s first urine test’ to spot cancer

Engineering and IT conglomerate Hitachi developed the basic technology to detect breast or colon cancer from urine samples two years ago (Shutterstock)
Updated 17 April 2018
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Japan to trial ‘world’s first urine test’ to spot cancer

  • Previous research has shown a new blood test has potential to detect eight different kinds of tumors before they spread
  • The research starts in April and will run until September

TOKYO: A Japanese firm is poised to carry out what it hailed as the world’s first experiment to test for cancer using urine samples, which would greatly facilitate screening for the deadly disease.
Engineering and IT conglomerate Hitachi developed the basic technology to detect breast or colon cancer from urine samples two years ago.
It will now begin testing the method using some 250 urine samples, to see if samples at room temperature are suitable for analysis, Hitachi spokesman Chiharu Odaira told AFP.
“If this method is put to practical use, it will be a lot easier for people to get a cancer test, as there will be no need to go to a medical organization for a blood test,” he said.
It is also intended to be used to detect paediatric cancers.
“That will be especially beneficial in testing for small children” who are often afraid of needles, added Odaira.
Research published earlier this year demonstrated that a new blood test has shown promise toward detecting eight different kinds of tumors before they spread elsewhere in the body.
Usual diagnostic methods for breast cancer consist of a mammogram followed by a biopsy if a risk is detected.
For colon cancer, screening is generally conducted via a stool test and a colonoscopy for patients at high risk.
The Hitachi technology centers around detecting waste materials inside urine samples that act as a “biomarker” — a naturally occurring substance by which a particular disease can be identified, the company said in a statement.
The procedure aims to improve the early detection of cancer, saving lives and reducing the medical and social cost to the country, Odaira explained.
The experiment will start this month until through September in cooperation with Nagoya University in central Japan.
“We aim to put the technology in use in the 2020s, although this depends on various things such as getting approval from the authorities,” Odaira said.


Scientists create bee vaccine to fight off ‘insect apocalypse’

Photo taken on August 2, 2018 shows a bee collecting pollen from a flower in Kirkkonummi, Finland. Scientists in Finland have developed what they believe is the world's first vaccine to protect bees against disease, raising hopes for tackling the drastic decline in insect numbers which could cause a global food crisis. (AFP)
Updated 16 December 2018
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Scientists create bee vaccine to fight off ‘insect apocalypse’

  • The vaccine, developed by a team at Helsinki University in Finland, works by giving bees resistance to fight off severe microbial diseases that can be fatal for pollinator communities

HELSINKI: Scientists in Finland have developed what they believe is the world’s first vaccine to protect bees against disease, raising hopes for tackling the drastic decline in insect numbers which could cause a global food crisis.
Bees are vital for growing the world’s food as they help fertilize three out of four crops around the globe, by transferring pollen from male to female flowers.
But in recent years bee populations around the world have been dying off from “colony collapse disorder,” a mysterious scourge blamed on mites, pesticides, virus, fungus, or some combination of these factors.
UN-led research in 2016 found that more than 40 percent of invertebrate pollinators, particularly bees and butterflies, are facing extinction.
The study also found that 16.5 percent of vertebrate pollinators, such as birds and bats, are under threat.
Scientists warn that the die-off will result in higher food prices and the risk of shortages.

The vaccine, developed by a team at Helsinki University in Finland, works by giving bees resistance to fight off severe microbial diseases that can be fatal for pollinator communities.
“If we can save even a small part of the bee population with this invention, I think we have done our good deed and saved the world a little bit,” lead researcher Dalial Freitak said.
“Even a two-to-three percent increase in the bee population would be humongous,” she told AFP.
Vaccinating insects was previously thought to be impossible because the creatures lack antibodies, one of the key mechanisms humans and other animals use to fight disease.
But a breakthrough came in 2014 when Freitak, a specialist in insects and immunology, noticed that moths who are fed certain bacteria can in fact pass on immunity to their offspring.
“They could actually convey something by eating. I just didn’t know what the mechanism was,” Freitak said.
“I met with Heli Salmela, who was working on honey bees and a protein called vitellogenin. I heard her talk and I was like, ‘OK, I could make a bet that it is your protein that takes my signal from one generation to another’.”
The pair started to collaborate and created a vaccine against American foulbrood, the most globally widespread and destructive bee bacterial disease.
The treatment is administered to the queen bee via a sugar lump, similar to the way many children are given polio vaccines. The queen then passes the immunity to her offspring, spreading it through the bee community.
As well as working on vaccines against further diseases, the team has also begun trying to raise funding to make the vaccine commercially available, with “very positive” feedback so far, according to Freitak.
“There are many regulatory hurdles. Four to five years until reaching the market is an optimistic estimate,” she said.

Diseases are believed to be just one of a number of reasons for the loss of pollinators, alongside pesticides and intensive farming, which reduces the diversity of insects’ nutrition.
But the team believes that protecting bee populations against disease will make them stronger, and therefore better able to withstand the other threats.
The European Union and Canada have voted to introduce bans on insecticides based on neonicotinoids after studies showed the chemicals harmed the ability of bees to reproduce.
UN-backed research in 2016 estimated that up to $577 billion (511 billion euros) worth of food grown every year relies directly on pollinators.
The study said the volume of food produced that depends on pollinators has risen by 300 percent in the last half century.
As pollinator numbers have declined, some farmers have turned to either renting bees or pollinating by hand — as with fruit trees in some parts of China — in order to replace the processes that nature previously provided free of charge.
In Helsinki the project relied on external funding, but the team has now taken up a more secure tenure at Graz University in Austria, where further research on vaccinations will begin early next year.
Graz is also the previous seat of noted zoologist Karl von Frisch, whose discovery that honey bees communicate by performing the figure-of-eight “waggle dance” won him the Nobel Medicine Prize in 1973.