Study details how high fiber diets make for healthier lives

This undated photo provided by America's Test Kitchen in December 2018 shows Tabbouleh in Brookline, Mass. (AP)
Updated 11 January 2019
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Study details how high fiber diets make for healthier lives

  • A good target for those wanting to reap health gains would be to eat 25g to 29g of dietary fiber a day

LONDON: People who eat lots of high-fiber and whole grain foods have lower risk of heart disease, stroke, diabetes and other chronic diseases than people whose diets are low in fiber, a study commissioned by the World Health Organization (WHO) says.
For every 8 gram increase in fiber eaten a day, total deaths and incidences of heart disease, type 2 diabetes and bowel cancer fell by 5 to 27 percent, the study said. Protection against stroke and breast cancer also rose.
A good target for those wanting to reap health gains would be to eat 25g to 29g of dietary fiber a day, the analysis found. But the data, published in a series of systematic reviews and meta-analyzes in The Lancet medical journal, also suggested higher dietary fiber intakes could give even greater protection.
“Our findings provide convincing evidence for nutrition guidelines to focus on increasing dietary fiber and on replacing refined grains with whole grains. This reduces incidence risk and mortality from a broad range of important diseases,” said Jim Mann, a professor at the University of Otago, New Zealand who co-led the research.
According to the study, most people worldwide currently consume less than 20g of dietary fiber a day. In Britain in 2015, an advisory committee on nutrition recommended an increase in dietary fiber intake to 30g a day, but only 9 percent of British adults manage to reach this target. In the United States, fiber intake among adults averages 15g a day.
Mann said the health benefits of dietary fiber — contained in foods such as whole grains, pulses, vegetables and fruit — come from its chemistry, physical properties, physiology and its effects on metabolism.
“Fibre-rich whole foods that require chewing and retain much of their structure in the gut increase satiety and help weight control, He said. “(And) the breakdown of fiber in the large bowel by the resident bacteria has additional wide-ranging effects including protection from colorectal cancer.” (Reporting by Kate Kelland)


Jazz Pharma’s sleep disorder treatment gets US FDA nod

Updated 21 March 2019
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Jazz Pharma’s sleep disorder treatment gets US FDA nod

  • The drug, solriamfetol, will treat excessive sleepiness in adult patients with narcolepsy or obstructive sleep apnea
  • The patent of Jazz's narcolepsy drug, Xyrem, were declared invalid by a US appeals court in July
The US Food and Drug Administration approved Jazz Pharmaceuticals Plc’s treatment for patients with a form of sleep disorder, the company said on Wednesday.
The drug, solriamfetol, will treat excessive sleepiness in adult patients with narcolepsy or obstructive sleep apnea (OSA).
Solriamfetol is expected to be commercially available in the United States following the final scheduling decision by the Drug Enforcement Administration (DEA), Jazz said in a statement.
The approval comes as Jazz is trying to reduce its reliance on its blockbuster narcolepsy drug, Xyrem, whose patents were declared invalid by a US appeals court in July.
Xyrem is an approved treatment for excessive daytime sleepiness and cataplexy in patients with narcolepsy. It brought in sales of $1.4 billion in 2018 and accounted for about 70 percent of company’s revenue.
“Jazz is trying to reduce its reliance on Xyrem, and solriamfetol will be one of the drugs it plans to launch to do that,” Mizuho Securities USA analyst Irina Koffler said ahead of the agency’s decision.
“Solriamfetol is expected to be an important driver of both diversification and growth,” RBC Capital Markets analyst Randall Stanicky said in a note ahead of the approval.
Solriamfetol is expected to bring in revenue of $314 million by 2024, Stanicky said.
Narcolepsy is a chronic sleep disorder with overwhelming daytime drowsiness and sudden attacks of sleep, while obstructive sleep apnea is a potentially serious sleep disorder that can cause breathing to repeatedly stop and start.
“Narcolepsy is very disabling to people as they often get diagnosed young and stop their education and drop out of high school or college,” Koffler said.
“Sleep apnea is a different problem in the sense that a lot of people don’t know they have it, have trouble breathing at night and they even fall asleep during the day.”