Scientists close in on blood test for Alzheimer’s

In this July 9, 2019 photo, Dr. Jori Fleisher, neurologist, examines Thomas Doyle, 66, at the Rush University Medical Center in Chicago. (AP)
Updated 16 July 2019

Scientists close in on blood test for Alzheimer’s

  • One of the experimental blood tests measures abnormal versions of the protein that forms the plaques in the brain that are the hallmark of Alzheimer’s

LOS ANGELES: Scientists are closing in on a long-sought goal — a blood test to screen people for possible signs of Alzheimer’s disease and other forms of dementia.
On Monday at the Alzheimer’s Association International Conference, half a dozen research groups gave new results on various experimental tests, including one that seems 88% accurate at indicating Alzheimer’s risk.
Doctors are hoping for something to use during routine exams, where most dementia symptoms are evaluated, to gauge who needs more extensive testing. Current tools such as brain scans and spinal fluid tests are too expensive or impractical for regular check-ups.
“We need something quicker and dirtier. It doesn’t have to be perfect” to be useful for screening, said Maria Carrillo, the Alzheimer’s Association’s chief science officer.
Dr. Richard Hodes, director of the National Institute on Aging, called the new results “very promising” and said blood tests soon will be used to choose and monitor people for federally funded studies, though it will take a little longer to establish their value in routine medical care.
“In the past year we’ve seen a dramatic acceleration in progress” on these tests, he said. “This has happened at a pace that is far faster than any of us would have expected.”
It can’t come too soon for patients like Tom Doyle, a 66-year-old former university professor from Chicago who has had two spinal fluid tests since developing memory problems four years ago. First he was told he didn’t have Alzheimer’s, then that he did. He ultimately was diagnosed with different problems — Lewy body dementia with Parkinson’s.
“They probably could have diagnosed me years ago accurately if they had had a blood test,” said Doyle, who represents patients on the Alzheimer’s Association’s board.
About 50 million people worldwide have dementia, and Alzheimer’s is the most common form. There is no cure; current medicines just temporarily ease symptoms. Dozens of hoped-for treatments have failed. Doctors think studies may have enrolled people after too much brain damage had occurred and included too many people with problems other than Alzheimer’s.
A blood test — rather than subjective estimates of thinking skills — could get the right people into studies sooner.

One of the experimental blood tests measures abnormal versions of the protein that forms the plaques in the brain that are the hallmark of Alzheimer’s. Last year, Japanese researchers published a study of it and on Monday they gave results from validation testing on 201 people with Alzheimer’s, other types of dementia, mild impairment or no symptoms.
The blood test results closely matched those from the top tests used now — three types of brain scans and a mental assessment exam, said Dr. Akinori Nakamura of the National Center for Geriatrics and Gerontology in Obu, Japan. The test correctly identified 92% of people who had Alzheimer’s and correctly ruled out 85% who did not have it, for an overall accuracy of 88%.
Shimadzu Corp. has rights to the test and is working to commercialize it, Nakamura said.
Another experimental test looks at neurofilament light, a protein that’s a marker of nerve damage. Abdul Hye of King’s College London gave results of a study comparing blood levels of it in 2,300 people with various neurological conditions — Alzheimer’s, other dementias, Parkinson’s, depression, multiple sclerosis, Lou Gehrig’s disease — plus healthy folks for comparison.
Levels were significantly higher in eight conditions, and only 2% of healthy folks were above a threshold they set for raising concern. The test doesn’t reveal which disorder someone has, but it may help rule one out when symptoms may be psychological or due to other problems.
Later at the conference, Dr. Randall Bateman of Washington University School of Medicine in St. Louis will give new results on a blood test he helped develop that the university has patented and licensed to C2N Diagnostics, a company he co-founded. Like the Japanese test, it measures the abnormal Alzheimer protein, and the new results will show how well the test reflects what brain scans show on nearly 500 people.
“Everyone’s finding the same thing ... the results are remarkably similar across countries, across techniques,” said Bateman, whose work is supported by the US government and the Alzheimer’s Association. He estimates a screening test could be as close as three years away.
What good will that do without a cure?
An Associated Press-NORC Center for Public Affairs Research poll last year found that most Americans would want to know if they carried a gene tied to a disease even if it was incurable.
“What people want most of all is a diagnosis” if they’re having symptoms, said Jonathan Schott of University College London. “What we don’t like is not knowing what’s going on.”


Russia to send ‘Fedor’ its first humanoid robot into space

Updated 22 August 2019

Russia to send ‘Fedor’ its first humanoid robot into space

  • Fedor was to blast off in a Soyuz rocket at 6:38 am Moscow time (0338 GMT) from Russia’s Baikonur cosmodrome
  • Fedor is not the first robot to go into space

MOSCOW: Russia was set to launch on Thursday an unmanned rocket carrying a life-size humanoid robot that will spend 10 days learning to assist astronauts on the International Space Station.
Named Fedor, for Final Experimental Demonstration Object Research with identification number Skybot F850, the robot is the first ever sent up by Russia.
Fedor was to blast off in a Soyuz rocket at 6:38 am Moscow time from Russia’s Baikonur cosmodrome in Kazakhstan, dock with the space station on Saturday and stay till September 7.
The Soyuz spacecraft is normally manned on such trips, but on Thursday no humans will be traveling in order to test a new emergency rescue system.
Instead of cosmonauts, Fedor will sit in a specially adapted pilot’s seat.

The silvery anthropomorphic robot stands one meter 80 centimeters tall (5 foot 11 inches) and weighs 160 kilograms (353 lbs).
Fedor has Instagram and Twitter accounts that describe it as learning new skills such as opening a bottle of water. In the station, it will trial those manual skills in very low gravity.
“That’s connecting and disconnecting electric cables, using standard items from a screwdriver and a spanner to a fire extinguisher,” the Russian space agency’s director for prospective programs and science, Alexander Bloshenko, said in televised comments.
Fedor copies human movements, a key skill that allows it to remotely help astronauts or even people on Earth carry out tasks while they are strapped into an exoskeleton.
Such robots will eventually carry out dangerous operations such as space walks, Bloshenko told RIA Novosti state news agency.
On the website of one of the state backers of the project, the Foundation of Advanced Research Projects, Fedor is described as potentially useful on Earth for working in high radiation environments, de-mining and tricky rescue missions.
On board, the robot will perform tasks supervised by Russian cosmonaut Alexander Skvortsov, who joined the ISS last month, and will wear an exoskeleton in a series of experiments scheduled for later this month.

Robonaut 2, Kirobo
Space agency chief Dmitry Rogozin showed pictures of the robot to President Vladimir Putin this month, saying it will be “an assistant to the crew.”
“In the future we plan that this machine will also help us conquer deep space,” he added.
Fedor is not the first robot to go into space.
In 2011, NASA sent up Robonaut 2, a humanoid robot developed with General Motors and a similar aim of working in high-risk environments.
It was flown back to Earth in 2018 after experiencing technical problems.
In 2013, Japan sent up a small robot called Kirobo along with the ISS’s first Japanese space commander. Developed with Toyota, it was able to hold conversations — albeit only in Japanese.