King Abdullah University of Science and Technology research sheds light on brain function

Dr. Corrado Cali explores 3D reconstructions of extremely complex brain cells known as astrocytes, within KAUST’s Visualization Core labs.
Updated 05 November 2019

King Abdullah University of Science and Technology research sheds light on brain function

Researchers at King Abdullah University of Science and Technology (KAUST) are officially one step closer to understanding the brain and its function.
Dr. Corrado Calì, a research scientist specializing in brain imaging at KAUST, and Swiss scientists from the Blue Brain Project (BBP), have shown how lactate is necessary for memory formation and learning. The project falls under the umbrella of the ambitious European Human Brain Project consortium framework.
Through a number of imaging experiments at KAUST’s Visualization Core labs in the past five years, Dr. Calì was able to produce three-dimensional models of astrocytes, necessary to simulate with spatial accuracy the metabolic coupling between neurons and glial cells using mathematical models developed by the BBP.
“Astrocytes are cells that store energy, and give energy to neurons at multiple levels,” Dr. Cali said. “To do that, it was important to produce accurate 3D reconstructions of these astrocytes.”
The research, published in the journal ScienceDirect, uses a technique called serial block-face electron microscopy to generate an image stack — a collection of images that can produce a volumetric image of a piece of tissue that contains astrocytes. He was then able to segment them and reconstruct the cells.
Astrocytes are known to be extremely complex in structure, rendering it impossible to image them in their entirety using light or fluorescence microscopy techniques, unless performed through electro-microscopy.

HIGHLIGHT

As of yet, the role astrocytes — a type of brain cells — play in brain function is not well understood. Increasingly, work is suggesting that designing drugs that can help these cells to better function during pathological conditions, helps the brain recover during a stroke.

As of yet, the role astrocytes — a type of brain cells — play in brain function is not well understood. Increasingly, work is suggesting that designing drugs that can help these cells to better function during pathological conditions, helps the brain recover during a stroke or Alzheimer’s Disease. “We could help to slow down the disease by acting specifically on these cells,” Dr. Calì noted.
“The first step to understand how the cell works is to understand how it is structured and this is the first work in literature where we see in detail, in 3D, the full structure of an astrocyte.”
The groundbreaking work could allow scientists to understand if different compartments of astrocytes behave differently.
Dr. Calì believes learning how the brain uses lactate is important, as several studies from the CHUV Hospital in Lausanne, Switzerland show, for instance, that lactate injections within 30 minutes from a stroke can significantly reduce the infarcted brain areas. It can also drastically improve the recovery of normal functions on affected patients, while other studies demonstrate the efficacy of lactate on reversing depression.
“By understanding deeply, from a cellular and molecular point of view its mechanism of action, we can design and maximize the efficiency of treatments based on lactate,” Dr. Cali concluded.


STC offers free 5G service for two months

Nasser Al-Nasser CEO of STC
Updated 12 November 2019

STC offers free 5G service for two months

Saudi Telecom Company (STC) is offering its 5G services free of cost for a period of two months starting from the subscription date. This service will enable customers to benefit from high speeds based on STC’s strong network in the Kingdom.
STC CEO Nasser Al-Nasser confirmed the group’s commitment to continue leading in the 5G era, highlighting its leadership as the first operator in the Kingdom and the Middle East to launch the live network for 5G in May 2018.
The telecom giant had deployed its 5G network at 196 sites in Makkah, Madinah and other holy places, such as Mina, Arafat and Muzdalifah during Hajj this year.
“The launch of the 5G package reflects STC’s commitment to its pivotal role as a key enabler of digital transformation and the development of the telecommunications and information technology sector in the Kingdom,” Al-Nasser added.