Although Roza Otunbayeva did not specify what could be discussed, such talks would likely focus on terms for President Kurmanbek Bakiyev's resignation. Bakiyev claims he's still the legitimate ruler, but would be willing to resign in exchange for security guarantees for him and close relatives.
Bakiyev, who has taken refuge in his home village far from the capital Bishkek, has repeatedly offered to engage in talks, but the interim government had refused.
Bakiyev fled the capital on April 7 after a protest rally exploded into gunfire and demonstrators seized government buildings. At least 83 people died.
Asked about the prospect of talks after meeting with U.S. Assistant Secretary of State Robert Blake, Otunbayeva said, "We will see. We would have to determine a format for such a meeting."
Blake's visit to meet with the interim authorities underlined Washington's strong concern about stability in Kyrgyzstan, where the United States has an air base that is key to military operations against the Taliban in Afghanistan.
There has been little violence in Kyrgyzstan since the uprising and some subsequent clashes between looters and security forces. Both sides appear to be maneuvering for advantage without setting off new bloodshed, but tensions and defiance are rising amid the stalemate.
The acting vice-premier on Tuesday had warned that special forces would mount an operation to arrest Bakiyev if he did not return to the capital.
One of Bakiyev's brothers, Akhmat, told the Associated Press in the family stronghold village of Teyit on Wednesday that "we are in full combat readiness... If they shoot, I'll start shooting."
The head of a civil-society group that visited the deposed president on Wednesday warned against any force to seize him.
"Bakiyev has armed his guards with military weapons. This means that in a special operation there could be victims from the side of Bakiyev's supporters, the security structures and peaceful citizens," Aziza Abdrasulova said.
Among the most difficult issues in a possible Bakiyev resignation is whether he would stay in the country. Bakiyev has shown no inclination to leave, and there are no obvious countries for him to go to for asylum. But the interim authorities have ordered him stripped of presidential immunity.
"If he is in our hands, we will take him to court," Otunbayeva said. She also said security guarantees for his family members would be "impossible."
One of Bakiyev's brothers, Zhanybek, was head of the state security guard service and is accused by the opposition of ordering his men to open fire on peaceful protesters.
"I don't consider myself guilty of what happened. I say as a lawyer that all my actions were lawful," Zhanybek Bakiyev told AP.
