Hughes (2-0) struck out a career-high 10 in the Yankees' sixth straight win. He was in complete control until Eric Chavez opened the eighth with a one-hopper that went back to the mound. The Yankees pitcher had little time to react and the ball struck his left hip. Hughes couldn't find the ball in front of the mound as Chavez hustled for a single.
This was the second near miss for the defending World Series champions in a couple of weeks. C.C. Sabathia held Tampa Bay hitless for 7 2-3 innings.
In Minneapolish, Francisco Liriano struck out six in eight scoreless innings to guide Minnesota over Cleveland.
Liriano (2-1) walked just two in a return to the form that made him an All-Star in 2006.
Michael Cuddyer had a homer, a two-run triple in the eighth and three RBIs for the Twins.
Indians starter David Huff (1-2) walked six and allowed four runs in six innings.
In Chicago, Tampa Bay rookie Wade Davis outpitched a very imperfect Mark Buehrle as the Rays smashed Chicago.
Davis (1-1) struck out six in six scoreless innings. After giving up a bunt single to start the game and walking three of the next five batters, he settled down, didn't walk anybody else and the only other hit he allowed was a single in the sixth.
Tampa Bay's Sean Rodriguez homered and drove in four runs.
Buehrle (2-2) was facing the Rays for the first time since his perfect game against them last season. He allowed six runs in 4 2-3 innings as the White Sox lost for the fifth time in six games to fall into last place in the AL Central.
In Anaheim, California, Miguel Cabrera hit a tying homer leading off the ninth inning and Ramon Santiago drove in the winner as Detroit edged Los Angeles.
Angels reliever Brian Fuentes (0-1), just off the disabled list after missing 14 games with a back strain, went to a full count against Cabrera before the Tigers' cleanup hitter homered to left-center. It was his fourth home run of the season and team-high 18th RBI.
Fuentes then walked Carlos Guillen and struck out Dan Kelly. Guillen stole second before a walk to Gerald Laird.
Guillen was picked off on the basepath for the second out, but Santiago got a single to left field to score Laird.
Detroit's Phil Coke (2-0) got the win with a scoreless eighth inning.
In Toronto, Alex Gordon picked a good time for his first homer of the season, going long with two outs in the tenth to give Kansas City victory over Toronto.
Gordon drove a pitch from Scott Downs (0-1) to centerfield. It was just the second hit of the season for Gordon, who missed the first 10 games with a broken thumb.
Jose Guillen hit a three-run homer for Kansas City and Alex Gonzalez had a two-run shot for Toronto, before the Blue Jays scored a run in the eighth to tie the game.
Robinson Tejeda (1-1) worked one inning for the win as the Royals avoided a series sweep.
In Boston, Kevin Youkilis hit an RBI double with two outs in the 12th as Boston sneaked a victory that extended Texas' losing skid to six games.
Youkilis' shot rebounded off the base of the left-center field wall. It was Boston's second straight last at-bat win.
J.D. Drew hit a grand slam for the Red Sox, and Darnell McDonald homered in his second straight game.
Texas' Josh Hamilton hit a three-run homer in the seventh that made it 7-7.
Neither team did much in the extra innings until Marco Scutaro singled with one out in the 12th. After an intentional walk, Youkilis delivered against Dustin Nippert (0-2).
In Seattle, Felix Hernandez pitched the eighth complete-game of his career to steer Seattle past Baltimore.
Hernandez (2-0) wasn't at his sharpest, but didn't issue a walk and limited Baltimore to a lone unearned run.
Jack Wilson provided a decisive three-run double as the Mariners completed the three-game sweep of the Orioles, who dropped to 2-14 and continued the worst start for the franchise since 1988.
Kevin Millwood (0-3) threw a complete-game for Baltimore.
