Rajon Rondo had 22 assists, 12 points and 10 rebounds for his 11th career triple-double and added six steals.
His final rebound came at the death. After a timeout, San Antonio had a chance to tie the game. Ginobli worked down the clock and put up a shot that was blocked by Paul Pierce and Rondo pulled down the rebound.
It's the first time this season that the Spurs (29-6), who still have the best record in the NBA, have lost back-to-back games.
Ray Allen scored 31 for Eastern Conference-leading Boston (27-7), but missed a pair of free throws with 8.1 seconds left that gave the Spurs one last shot.
Ginobili had 24 points and eight rebounds for San Antonio.
In Salt Lake City, Joe Johnson scored 28 points, making five of seven 3-pointers, to lift Atlanta to victory over Utah.
Jamal Crawford added 26 off the bench for the Hawks, who have won three straight road games.
Deron Williams and Andrei Kirilenko each had 19 points to lead the Jazz, who were without second-leading scorer Paul Millsap because of a bruised hip.
The Hawks hurt the Jazz with 3-pointers, hitting 14 of 25 on the night, including a half court buzzer-beater from Crawford for a 55-41 halftime lead.
Atlanta led 30-17 after one, with the Jazz shooting just 35.3 percent to 52.4 percent for the Hawks.
In Phoenix, five Los Angeles players reached double figures as the Lakers edged Phoenix.
Kobe Bryant scored 24 points and Andrew Bynum had 14 for L.A. Ron Artest sank a 3-pointer with 90 seconds left after the Suns had got within a point.
Jared Dudley led Phoenix with 21 points, including three of their 11 3-pointers, but the much bigger Lakers dominated the boards 47-31, including 14-5 on the offensive end.
In Orlando, the hosts held off injury-depleted Milwaukee for a seventh straight victory.
Milwaukee was without three of its five top scorers in guard Brandon Jennings, Carlos Delfino and Drew Gooden.
Dwight Howard had 28 points and 13 rebounds as Orlando avenged an 11-point loss at Milwaukee on Dec. 4 in which it played without Howard, Jameer Nelson and J.J. Redick.
The Magic led by as many as 19 before their lead was cut to five with 4:06 remaining. A basket by Howard and 3-pointer by Hedo Turkoglu got the lead back to 10 and helped the Magic secure the win despite shooting just 5 of 22 from beyond the arc.
Corey Maggette led Milwaukee with 21 points.
In Houston, Portland overcame Kevin Martin's season-high 45 points to beat Houston.
Rudy Fernandez gave the Trail Blazers the lead with less than a minute remaining. Martin missed a shot on the other end and LaMarcus Aldridge grabbed the rebound and extended the lead with his bucket a few seconds later.
Luis Scola missed a shot for Houston and Aldridge was fouled on the rebound. Aldridge hit two free throws with 5 seconds remaining to take his game tally to 27 points.
before Kyle Lowry made a 3-pointer with 3.1 seconds left to cut the lead to 102-100.
Andre Miller made a free throw before Courtney Lee's shot at the buzzer bounced off the rim.
In New Orleans, Monta Ellis scored 29 points as Golden State rallied past New Orleans.
Trailing by 10 after three quarters, the Warriors went on a 27-7 run in the first 7 minutes of the fourth to go ahead 99-89, then hit their free throws late to seal the victory after the Hornets got within two.
Stephen Curry had 21 points for Golden State.
Chris Paul led New Orleans with 24 points, one off his season high, but was scoreless for the first 11 minutes of the fourth quarter.
In Newark, New Jersey, Sasha Vujacic made the tiebreaking basket with 5.3 seconds left and New Jersey snapped a five-game losing streak by beating Chicago.
With the game tied, the ball was knocked to Vujacic, who put it in for his 13th point. Derrick Rose then missed a long jumper and Chicago's five-game winning streak was over.
Kris Humphries responded to a demotion with a season-high 20 points and 11 rebounds for the Nets.
Rose had 21 points but just one assist for the Bulls.
In Los Angeles, the home team snapped Denver's four-game winning streak.
Eric Gordon scored 28 points, including four 3-pointers, while Blake Griffin had 22 points and 18 rebounds to tie a Clippers franchise record with his 22nd consecutive double double.
Los Angeles outrebounded the Nuggets 57-43 to halt a four-game losing streak against Denver.
Carmelo Anthony had 31 points for the Nuggets, who took their only lead early in the first quarter.
In Philadelphia, the hosts returned from their longest road trip of the season to beat Washington.
Jrue Holiday and Lou Williams each scored 26 points for the Sixers, who earlier in the season lost twice at Washington in overtime by a combined three points.
Nick Young scored 21 points for the Wizards, who are 0-17 on the road this season.
In Minneapolis, Charlotte rallied from eight points down in the final 3 minutes to pull out an overtime victory against Minnesota.
D.J. Augustin scored eight points in the final 2:08 of regulation to tie the game and the Bobcats snapped a nine-game road losing streak without injured leading scorers Stephen Jackson and Gerald Wallace.
Tyrus Thomas had 21 points and 11 rebounds to lead Charlotte.
Kevin Love had 35 points and 15 rebounds for the Wolves, who turned the ball over five times in overtime to let another fourth-quarter lead slip away.
In Cleveland, Toronto ended a succession of 11 straight losses in Cleveland.
Andrea Bargnani scored 25 points and Leandro Barbosa added 22 for Toronto, which snapped a three-game skid. The Raptors trailed by 15 after a quarter, but had little trouble coming back against the getting-worse-by-the-day Cavaliers, who have lost eight straight.
Antawn Jamison scored 32 for Cleveland.
