Madrid and Barcelona both play their first leg at home, and
big victories there would all but end their opponents' hopes of pulling off an
upset in the return match.
Strong results for the Spanish giants would also set up
another likely matchup between them later this month, as the winners will meet
in the two-legged quarterfinals of the cup competition.
Malaga hasn't beaten Madrid since its return to regular
first division football in 1999, while Osasuna will face a Barcelona side that
has won its last five matches at the Camp Nou by a combined score of 26-0.
Malaga's ambitious owners have gone on a spending spree
lately to buy players in a bid to see the Andalucian club compete at the top of
the table, but Madrid has won the last three meetings between the sides by a
combined score of 15-1 going into Tuesday's game.
"We hope for a good result, which is not to lose and to
score goals," Malaga coach Manuel Pellegrini said on Monday. "If we
can't win, a draw, and if we are going to lose we'll score goals and not just
sit in our backfield looking to defend." Madrid, which beat Barcelona in
last year's final, will likely be without injured players Angel di Maria,
Sergio Ramos and Ricardo Carvalho, while Malaga remains without Brazilian
striker Julio Baptista and winger Joaquin Sanchez. In-form winger Jose Callejon
is expected to fill in for Di Maria, while either Raul Albiol or Rafael Varane
can replace Ramos if the Spain international doesn't recover from a leg injury
in time to play at the Santiago Bernabeu stadium.
"Di Maria's absence will affect them some,"
Cazorla said. "But whoever plays, it's going to be a complicated
match." Barcelona, meanwhile, has 12 wins and two draws in 14 games at the
Camp Nou this season, where it has outscored opponents 59-4. It already beat
Osasuna 8-0 on home soil this season.
Lionel Messi's availability is questionable, as the
Argentine forward did not train with the team on Monday after just returning
from a winter holiday. But several injured players did return to training and
could be available on Wednesday, including Andres Iniesta, Alexis Sanchez,
Carles Puyol, Eric Abidal and Seydou Keita.
Osasuna is in good form and has climbed to a surprising
fifth place in the league after going unbeaten in its last seven games, a
streak that includes four wins.
"We know what can happen. (But) what matters to us is
Osasuna," Brazil fullback Adriano said Monday of the clasico possibility.
"If it's Madrid or Malaga, that'll come later." Valencia faces
Sevilla on Thursday in perhaps the most even matchup of the round, while all
four remaining lower-tier clubs host their first-leg matches against topflight
clubs.
Second-tier Alcorcon, which knocked Madrid out of the
competition in 2009 and beat Villarreal this time around, plays early-season
surprise Levante, with the winner of that series going on to play either
Valencia or Sevilla. Madrid and Barcelona are also on that side of the draw,
leaving the eight teams on the other half with a golden chance of reaching the
final.
Third-tier Albacete, which eliminated Atletico Madrid, on
Tuesday welcomes 23-time champion Athletic Bilbao, which is without injured
striker Fernando Llorente, while third-tier Mirandes welcomes struggling
topflight side Racing Santander. Espanyol is at second-division Cordoba on
Thursday, while Real Sociedad faces Mallorca on Wednesday.
