MELBOURNE: Andy Roddick outlasted Fernando Gonzalez of Chile to survive a Sunday of upsets at the Australian Open that resulted in fourth-round exits for US Open champion Juan Martin del Potro and two of the top three women.

The seventh-seeded Roddick rallied to beat Gonzalez 6-3, 3-6, 4-6, 7-5, 6-2 and advance to the quarterfinals at the season’s first major for the sixth time in eight years. He’ll next meet No. 14 Marin Cilic, who ousted del Potro in five sets and 4-hours, 38-minutes earlier in the evening.

“I got a little lucky tonight, but sometimes it’s better to be lucky than good,” said Roddick, who is hoping to end a Grand Slam title drought that dates back to the 2003 U.S. Open.

Two of Russia’s top hopes were ousted, but replaced by other Russians in the women’s draw.

Second-ranked Dinara Safina retired due to a back problem while she was down 4-5, serving at 30-40 in the first set against Maria Kirilenko, who had ousted 2008 champion and fellow Russian Maria Sharapova in the first round.

No. 3 Svetlana Kuznetsova lost 6-3, 3-6, 6-1 to Nadia Petrova, who went into the match after a stunning, 6-0, 6-1 third-round victory over U.S. Open champion Kim Clijsters.

While the seeded players dropped, former No. 1 Justine Henin continued her run in her first Grand Slam tournament in two years with a 7-6 (3), 1-6, 6-3 win over fellow Belgian Yanina Wickmayer, keeping her on track for a quarterfinal meeting with Petrova.

The other leading men are still here.

Defending champion Nadal and Andy Murray held off two of the tallest men and biggest servers in tennis earlier on Rod Laver Arena to set up a quarterfinal match up.

Nadal, who beat Federer in the 2009 final, had a 6-4, 4-6, 6-4, 6-4 win over 6-foot-10 Ivo Karlovic of Croatia, the tallest man on the tour.

No. 5 Murray overcame 6-foot-9 American John Isner 7-6 (4), 6-3, 6-2 to reach the final eight in Australia for the first time. The 22-year-old Scot hasn’t dropped a set in four matches.

No. 1 Federer and No. 3 Djokovic play their fourth-round matches Monday.

In an afternoon match, 2008 Wimbledon semifinalist Zheng Jie set another national mark by becoming the first Chinese player to reach the quarterfinals at Melbourne Park with a 7-6 (6), 6-4 victory over Alona Bondarenko. She next plays Kirilenko.

Henin, who is unranked and playing on a wild-card entry in her second tournament since returning from a 20-month retirement, told the crowd she’d missed tennis too much to resist a comeback.

The seven-time Grand Slam winner dominated the first-set tiebreaker after saving three set points in the 12th game. After dropping the second set, Henin broke Wickmayer’s serve to open the deciding third set and was on top after that.

“It’s been great moment for myself,” Henin said. “It’s a great feeling to be back, been a great fight and thank you.”