Casey Blake hit a two-run drive, Matt Kemp added a solo shot and Andre Ethier hit a three-run homer for the Dodgers, who beat San Francisco 11-1 in their 2009 home opener. Blake went 1 for 2 with a walk and is batting .389, carrying over his strong spring into the regular season.

Ramirez, Kemp and Ethier homered in the same game for the second time since Ramirez joined the Dodgers in 2008.

Clayton Kershaw(1-0) allowed two runs and three hits in 5 1-3 innings for Los Angeles.

Ian Kennedy (0-1) gave up six runs and six hits over 4 1-3 innings in his first game against the Dodgers.

In Miami,  Joey Votto drove in the go-ahead run with a two-out single in the 11th inning, and Cincinnati beat Florida in extra innings for the second night in a row.

Jonny Gomes and Ryan Hanigan hit three-run homers for the Reds. Brandon Phillips had four hits, including an RBI single in the 11th.

The Reds won despite blowing a 6-1 lead. They beat the Marlins 6-5 in 10 innings in the series opener Monday.

Jorge Cantu of Florida singled home a run and became the first player since 1921 to have at least one hit and one RBI in the first eight games of a season. Dan Meyer (0-1) got the loss.

Micah Owings (2-0) struck out three in two scoreless innings. Francisco Cordero pitched a perfect 11th for his fourth save in four chances.

In Denver, Greg Smith won for the first time in 19 months, riding a six-run third inning by Colorado to the victory.

Smith (1-1) struck out eight over seven innings, allowing two runs and six hits. He replaced fellow lefty Jeff Francis (strained left shoulder) in the Rockies' rotation at the end of spring training.

Smith also collected his first career RBIs when he stroked a run-scoring double into the left-field alley in the third and plated another run with a fielder's choice groundout in the seventh.

New York's John Maine (0-1) tied a career high by allowing eight runs in just three innings. He also yielded seven hits and walked three.

Smith picked up his first major league win since Sept. 6, 2008, for Oakland against Baltimore.

In San Francisco,  Pittsburgh's Garrett Jones had three hits and two RBIs, including the go-ahead run in the eighth inning.

Akinori Iwamura and Andy LaRoche homered for the Pirates, who ended a six-game losing streak at AT&T Park. It was their first victory in San Francisco since September 2008.

Evan Meek (1-0) pitched two scoreless innings for the win and Octavio Dotel held on for his second save in two opportunities.

Eugenio Velez hit a two-run homer off Dotel in the ninth but the closer responded by retiring three straight, getting Pablo Sandoval to line out to first to end the game.

Matt Cain allowed three runs and five hits in six innings for the Giants, who lost for just the second time. Cain retired the last 10 batters he faced.

Paul Maholm pitched five-plus innings for the Pirates, yielding three runs and eight hits.