His two-run, first-inning drive off Shaun Marcum put New York ahead, and the Yankees coasted to a 5-1 victory on a sweltering Wednesday afternoon to end a three-game losing streak.

A-Rod reached the milestone after a 12-game drought. At 35 years, 8 days, Rodriguez joined an elite club that includes Barry Bonds (762), Hank Aaron (755), Babe Ruth (714), Willie Mays (660), Ken Griffey Jr. (630) and Sammy Sosa (609). Ruth is next youngest at 36 years, 196 days.

Rodriguez received a brief ovation when he came up again in the third inning, then grounded out to shortstop en route to a 1-for-4 day. Derek Jeter had four hits and scored three runs, and Mark Teixeira drove in three runs to support Phil Hughes (13-4).

Marcum (10-5), who had won three straight starts, gave up five runs in six innings.

Athletics 4 Royals 3: At Oakland, California, Kevin Kouzmanoff hit a tiebreaking, two-run double in the sixth inning and the A’s took advantage of two errors to take the three-game series from Kansas City.

Brett Anderson (3-2) allowed three hits and two runs, struck out four and walked one in seven innings to win for the first time since May 29. It was a solid outing for the lefty in his second start since coming off the disabled list because of inflammation in his throwing elbow.

Sean O’Sullivan (1-2) is still looking for his first victory since joining the Royals. He made his first career start against Oakland and third outing for Kansas City since the Royals acquired him from the Angels on July 22.

White Sox 4  Tigers 1: At Detroit, Edwin Jackson won his debut with the White Sox, and Paul Konerko and Carlos Quentin homered.

Acquired from Arizona on July 30, Jackson (1-0) allowed one run over seven-plus innings. He was an All-Star with Detroit last season.

The loss dropped the Tigers eight games behind Chicago in the AL Central, matching their biggest deficit of the season.

Jackson gave up nine hits, but Detroit stranded 11 runners in its second loss to him this season. He left with a 4-0 lead after walking Miguel Cabrera to start the eighth. Bobby Jenks pitched the ninth for his 23rd save.

Indians 9 Red Sox 1: At Boston, Andy Marte hit a three-run homer in a five-run seventh inning, and Justin Masterson pitched five solid innings against his former team.

Jayson Nix homered off the Fisk Pole for Cleveland, which has won four out of five games to improve to 12-8 since the All-Star break and move out of last place and into a tie for fourth. The Indians took advantage of three Boston errors to score seven unearned runs, including all five in the seventh when they turned a 4-1 game into a 9-1 blowout.

David Ortiz homered for Boston, extending his hitting streak to 13 straight games — his longest in three years.

Orioles 9  Angels 7: At Baltimore, Luke Scott homered for the third straight game, and Baltimore improved to 2-0 under new manager Buck Showalter.

Felix Pie had three hits and three RBIs for the Orioles, who are already assured a fifth series win of the season — in 35 tries.

The Orioles still own the worst record in the majors (34-73). But they’ve looked sharp under Showalter, who has been asked to revive a franchise headed toward a 13th consecutive losing season.

Rookie Brian Matusz (4-11) allowed one run and seven hits in six innings to earn his first home win in 11 starts. He was 0-7 with a 5.55 ERA at Camden Yards.

Ervin Santana (10-8) allowed nine runs and 12 hits in 3 2-3 innings, his shortest outing of the season.

Twins 2  Rays 1,  13 innings: At St. Petersburg, Florida, Delmon Young had a tiebreaking RBI single in the 13th inning for Minnesota.

Alexi Casilla opened the 13th by drawing a walk from Lance Cormier (3-3) and advanced to third on Joe Mauer’s single. Young then made it 2-1 on a single to left.

Matt Guerrier (2-6) threw two perfect innings. He had lost all three of his previous appearances against Tampa Bay this year.

The Rays tied it at 1 in the ninth when Evan Longoria hit a leadoff double off Matt Capps and scored on Dan Johnson’s one-out single.