After New York blew a 16-point lead in the fourth quarter, the Jets trailed 27-23 with less than a minute left. But Sanchez completed two passes to LaDainian Tomlinson and then had a pretty 42-yard pass to Braylon Edwards with 16 seconds remaining.

On the next play, Sanchez found Holmes streaking into the left corner of the end zone for the winning score for the Jets (8-2). A video replay confirmed that Holmes, whose 37-yard touchdown catch won it in overtime at Cleveland last week, got both feet in bounds.

It was another heartbreaking loss for the Texans (4-6), who fell last week on a desperation heave as time expired at Jacksonville.

Patriots 31  Colts 28: In Foxborough, Massachusetts, Tom Brady barely outdueled Peyton Manning in their annual meeting, leading New England over Indianapolis.

The teams met for the eighth straight season, and Brady guided the Patriots (8-2) to a 31-14 lead before four-time MVP Manning led a spirited comeback. But Manning was intercepted in the final moments for the third time.

Brady not only beat Manning, the only other quarterback of the last decade in his class, but tied another QB icon for an NFL mark. Brady has won 25 straight regular-season home starts, equaling Brett Favre’s record when he was with Green Bay.

New England is tied with the Jets atop the AFC East. Indianapolis (6-4) leads the AFC South.

Eagles 27 Giants 17: In Philadelphia, LeSean McCoy ran 50 yards for the go-ahead score on a fourth-and-1 late in the fourth quarter, and the Eagles rallied after blowing a 13-point lead.

Michael Vick looked a little more ordinary after a spectacular performance in a 59-28 win over Washington Monday night, but he led the Eagles (7-3) to a comeback win nonetheless, and helped give them sole possession of first place in the NFC East.

Steelers 35 Raiders 3: In Pittsburgh, James Harrison caused two turnovers that Ben Roethlisberger turned into touchdown passes and the Steelers went on to rout the Raiders.

Harrison led a defense that drove Raiders quarterback Jason Campbell from the game, and finished with five tackles, two sacks, an interception and a forced fumble. The former AP NFL Defensive Player of the Year also was called for a penalty for slamming Campbell to the turf as the quarterback was throwing a pass.

Roethlisberger finished with three TD passes and also ran for one. He threw scoring passes of 52 yards to Mike Wallace , 22 yards to rookie Emmanuel Sanders and 16 yards to Isaac Redman . He also scrambled 16 yards for a touchdown as the Steelers (7-3) bounced back after being rolled over by New England 39-26 at Heinz Field last week. Oakland fell to 5-5.

Redskins 19 Titans 16 OT: In Nashville, Tennessee,  Graham Gano kicked a 48-yard field goal with 8:17 left in overtime to lift Washington.

Titans quarterback Vince Young left the game with an injured thumb on his throwing hand, and was replaced by rookie Rusty Smith .

Washington (5-5) snapped a two-game skid and bounced back from a 59-28 loss to Philadelphia on Monday night. The win came on a day when at least seven Redskins went to the sideline with injuries, including Clinton Portis with a re-injured groin.

Gano’s winner was his fourth field goal of the game. He also missed two — a 51-yarder to end the first half and a 47-yard attempt at the end of regulation that fell short.

Packers 31 Vikings 3: In Minneapolis, Aaron Rodgers threw for 301 yards, with three of his four touchdown passes to Greg Jennings , and Green Bay beat Brett Favre and Minnesota for the second time this season.

The Packers (7-3) kept pace in the NFC North race with the Chicago Bears (7-3) and ruined any realistic hope the Vikings (3-7) had left to give Favre another shot at a playoff run in his 20th NFL season.

Instead, this 100th meeting between these border-state rivals, likely the last for the 41-year-old Favre, was marked by costly turnovers, untimely penalties and some sideline shouting by the frustrated Vikings.

Cowboys 35 Lions 19: In Arlington, Texas, Bryan McCann grabbed a batted-down punt and returned it 97 yards for a touchdown, Miles Austin had two short touchdown catches and 38-year-old Jon Kitna had a career-best 29-yard TD for Dallas.

Cowboys interim coach Jason Garrett won his home debut and improved to 2-0 since taking over for Wade Phillips. It’s the first time all season Dallas (3-7) won at home, having lost the first four.

The Lions (2-8) lost their 26th straight on the road, extending a woeful NFL record that began in 2007, when Kitna was their quarterback.

Detroit led 12-7 and was consistently stuffing the Cowboys’ offense midway through the third quarter when John Wedling jumped over the goal line and tapped a punt back into the field of play.

It hopped up waist-high and right to McCann, and the speedster turned it into the second-longest punt return in franchise history — a week after a 101-yard interception return that was the longest in club history.

Ravens 37 Panthers 13: In Charlotte, North Carolina, Joe Flacco threw for 301 yards and a touchdown, Baltimore’s defense returned consecutive interceptions for TDs in the fourth quarter, and the Ravens beat Brian St. Pierre and the Panthers.

The Ravens (7-3) recovered after a disheartening loss to Atlanta 10 days earlier by finally rattling Carolina’s quarterback to break open a surprisingly close game. With Baltimore leading 23-13, Ed Reed picked off St. Pierre, then pitched it to Dawan Landry for a touchdown.

On the next play, St. Pierre was intercepted by Ray Lewis , who rumbled 24 yards for a score.

Bills 49 Bengals 31: In Cincinnati, Ryan Fitzpatrick matched his career high with four touchdown passes during Buffalo’s biggest comeback in 13 years, and the Bills won their second straight game.

The Bengals (2-8) appeared to be in control after Johnathan Joseph’s interception return put them ahead 28-7 in the second quarter. The Bengals’ smallest crowd since 2003 saw a vintage collapse.

Buffalo (2-8) took advantage of Cincinnati’s depleted secondary — Joseph and safety Chris Crocker went out late in the first half — for its biggest comeback since it overcame a 26-0 deficit and topped the Colts 37-35 on Sept. 21, 1997, according to STATS LLC.

Jaguars 24  Browns 20: In Jacksonville, Florida,  Maurice Jones-Drew followed a 75-yard reception with a 1-yard touchdown dive with 1:16 left as Jacksonville (6-4) overcame six turnovers.

Jones-Drew broke four tackles on a screen pass from David Garrard and weaved his way toward the end zone. Rookie Joe Haden made a touchdown-saving tackle that ended up taking precious seconds off the clock.

Jones-Drew scored two plays later, giving both teams dramatic finishes for the second time in as many games.

The Jaguars beat Houston last week on Garrard’s desperation pass to Mike Thomas on the final play. The Browns (3-7) lost to the New York Jets in overtime on Santonio Holmes’ 37-yard TD reception.

Chiefs 31 Cardinals 13: In Kansas City, Missouri,  Dwayne Bowe caught two touchdown passes, giving him a team-record six straight games with at least one score, and Kansas City remained unbeaten at home.

In his last six games, Bowe has 563 yards receiving and 10 touchdown catches for the Chiefs (6-4). Thomas Jones also had two touchdowns for the Chiefs, who are 5-0 at home and are in sole possession of first place in the AFC West.

The fifth straight loss for the Cardinals (3-7) dropped the two-time defending NFC West champions 2 1/2 games behind Seattle.

Buccaneers 21 49ers 0: In San Francisco, Josh Freeman threw for 136 yards and two touchdowns and Tampa Bay got its first win at Candlestick Park since 1980 and only second ever.

Nothing fancy needed for the Bucs (7-3) to end an eight-game losing streak in San Francisco. They were the underdog, no less.

Ronde Barber made his 40th career interception in the fourth quarter, most in Tampa Bay franchise history, to help clinch it. He also became the first player in NFL history to record 40 interceptions and 25 sacks in a career.

Saints 34 Seahawks 16: In New Orleans, Drew Brees became the Saints’ all-time completions leader, throwing for four touchdowns.

Brees was 29 of 42 for 382 yards and completed his 1,850th pass as a Saint in the second quarter to break a record held by Archie Manning since 1982.

Brees hit Marques Colston and Robert Meachem twice each for TDs to keep the defending champion Saints (7-3) one game behind NFC South Division leader Atlanta.

Matt Hasselbeck was 32 of 44 for 366 yards, the most yards allowed by New Orleans’ top-ranked passing defense this season, but Seattle (5-5) had trouble getting in the end zone. The Seahawks lost two fumbles and had four drives end with field goals.

Falcons 34  Rams 17: In St. Louis, Matt Ryan threw two touchdown passes and directed an offense so dominant that three St. Louis defenders left with cramps in Atlanta’s win.

Sam Bradford also had a pair of touchdown passes and set an NFL rookie record with 169 consecutive passes without an interception before William Moore picked off a shovel pass at the 2 with 3:24 to go. That was the clincher for the Falcons (8-2), who won their fourth in a row and ended the Rams’ four-game home winning streak.

Ryan was 26 of 39 for 253 yards with touchdown passes to Brian Finneran and Justin Peelle, and Roddy White set up scores with nine catches for 83 yards.

The Rams fell to 4-6.