The Hokies (19-8, 9-5 Atlantic Coast Conference), badly in need of a signature victory to enhance their NCAA tournament credentials, got it thanks to 12-4 run over a span of 4 1/2 minutes that turned a 53-47 deficit into a 62-57 lead with 2 minutes remaining.

The Blue Devils (26-3, 12-2) had chances in the closing minute to pull even when Virginia Tech struggled at the free throw line, but couldn’t capitalize. Duke had its seven-game winning streak snapped and allowed the Hokies to get a badly needed boost to their NCAA hopes.

No. 3 Kansas 82 Oklahoma 70: In Norman, Oklahoma, Marcus Morris had 23 points and nine rebounds, twin brother Markieff added 19 points and 10 boards, and the Jayhawks moved into a tie for first in the Big 12.

Kansas (27-2, 12-2) shot 57 percent, making more than half of their shots from the field for the 21st time this season, and notched their seventh straight win in the series.

Kansas opened a double-digit lead in the opening 8 minutes and led by at least 10 points for the final 27 minutes but struggled to put away the Sooners (12-16, 4-10), who lost their seventh straight game.

Colorado 91 No. 5 Texas 89: In Boulder, Colorado, Alec Burks scored 33 points and Levi Knutson added 21 as Colorado overcame a 22-point first-half deficit for the upset.

Colorado (18-11, 7-7 Big 12) was down 48-33 at halftime, but the Longhorns (24-5, 13-2) suddenly were affected by the altitude and the Buffaloes’ push-the-pace style.

No. 7 BYU 80 No. 6 San Diego St. 67: In San Diego, Jimmer Fredette scored 25 points and Charles Abouo added 18 as BYU spoiled the biggest game in San Diego State’s history and took a one-game lead in the Mountain West.

The Cougars (27-2, 13-1) swept the season series against the Aztecs (27-2, 12-2), who lost for the first time in 14 games this season at Viejas Arena.

Fredette, who scored 43 points in BYU’s 71-58 win over the Aztecs last month, helped the Cougars take control after SDSU pulled to 47-44 on James Rahon’s 3-pointer with just over 13 minutes to play.

No. 9 Notre Dame 60 Seton Hall 48: In South Bend, Indiana, Tim Abromaitis scored 22 points and Ben Hansbrough had 21 to help the Irish remain in position for a double-bye for the Big East tournament.

After trailing by 11 points in the first half, Notre Dame (23-5, 12-4) came back quickly in the second half. Carleton Scott’s 15-footer with 17:30 remaining gave the Irish a 31-30 edge. It was part of a 13-0 run that gave Notre Dame a 37-30 edge.

UCLA 71 No. 10 Arizona 49: In Los Angeles, Reeves Nelson had a career-high 27 points and 16 rebounds, and UCLA moved into a tie with Arizona for first place in the Pac-10 in the last men’s game played at historic Pauley Pavilion before it closes for renovation.

Joshua Smith added 17 points and Tyler Honeycutt had 15 for the Bruins (21-8), who share the league’s top spot at 12-4 with two games remaining. They have won 12 of 14.

No. 17 Syracuse 58 No. 11 Georgetown 51: In Washington, Scoop Jardine had 17 points and seven assists to lead Syracuse to its fourth straight win, as the Orange pulled away after the teams were tied 45-all late.

Syracuse (24-6, 11-6 Big East) limited the Hoyas, the sixth-best field-goal shooting team in the country, to 36 percent from the field.

Baylor 58 No. 21 Texas A&M 51: In Waco, Texas, LaceDarius Dunn and Perry Jones scored 16 points each as Baylor wrapped up a regular-season sweep of the Aggies.

Quincy Acy added 10 points for the Bears (18-10, 7-7 Big 12), who took a 76-74 overtime win in College Station on Feb. 5, the last loss before Texas A&M went on a five-game win streak.

Baylor led 41-32 with 10:29 left before Texas A&M went on a 7-0 run. Dunn then took over, hitting two 3-pointers, a pair of free throws after an intentional foul by David Lebeau, and two more foul shots for a 53-43 lead.

No. 22 Kentucky 76 No. 13 Florida 68: In Lexington, Kentucky, Darius Miller scored a career-high 24 points and Brandon Knight added 16 points and six assists as Kentucky stayed unbeaten at home under John Calipari.

Kentucky (20-8, 8-6 SEC) won its 33rd straight home game and gave coach John Calipari his 500th career victory. The Wildcats took control of a tight game with a 10-2 burst midway through the second half to get some breathing room at 58-49.

No. 23 St. John’s 81 No. 15 Villanova 68: In Philadelphia, Dwight Hardy scored a career-high 34 points and St. John’s showed it doesn’t need to be at Madison Square Garden to beat a ranked team.

The Red Storm (19-9, 11-5 Big East) won their sixth straight game and beat their first Top 25 team away from the Garden. Led by first-year coach Steve Lavin, the Red Storm have knocked off six ranked opponents this season.

No. 18 Vanderbilt 90 LSU 69: In Baton Rouge, Louisiana, Jeffery Taylor scored 20 points, John Jenkins overcame a slow start to score 17, and Vanderbilt outscored LSU 49-26 in the second half.

The Commodores (21-7, 9-5 SEC), which bounced back from their first loss in six games by shooting 54.4 percent. They surged to the lead for good with a 14-0 second-half run.

Kansas St. 80 No. 20 Missouri 70: In Manhattan, Kansas, Jacob Pullen scored 24 points and joined Mike Evans as the only players in Kansas State history to top the 2,000-point mark.

Curtis Kelly added 15 points for the resurgent Wildcats (20-9, 8-6), who have won six of seven and are battling Mizzou (22-7, 8-6) for the fourth and final bye in the Big 12 tournament.

No. 24 Temple 57 George Washington 41: In Washington, Lavoy Allen scored 19 points and had a season-high 16 rebounds for Temple, which overcame a horrific first 10 minutes in an ugly win.

After scoring just eight points in the opening 10 minutes, Temple (22-6, 12-2 Atlantic 10) took the lead for good by holding George Washington to two points over the final 11:22.