Japan team transplants stem cells into brain to treat Parkinson’s

Induced Pluripotent Stem cells are created by stimulating mature, already specialized, cells back into a juvenile state. (AFP)
Updated 09 November 2018

Japan team transplants stem cells into brain to treat Parkinson’s

  • The research team at Kyoto University injected induced Pluripotent Stem cells into the brain of a male patient in his fifties
  • Parkinson’s disease is a chronic, degenerative neurological disorder that affects the body’s motor system

TOKYO: Japanese researchers said Friday they have transplanted stem cells into the brain of a patient in the first stage of an innovative trial to cure Parkinson’s disease.
The research team at Kyoto University injected induced Pluripotent Stem (iPS) cells — which have the potential to develop into any cell in the body — into the brain of a male patient in his fifties, the university said in a press release.
The man was stable after the operation, which was performed last month, and he will now be monitored for two years, the university added.
The researchers injected 2.4 million iPS cells into the left side of the patient’s brain, in an operation that took about three hours.
If no problems are observed in the coming six months, they will implant another 2.4 million cells into the right side.
The iPS cells from healthy donors have been developed into the precursors of dopamine-producing brain cells, which are no longer present in people with Parkinson’s disease.
The operation came after the university announced in July they would carry out the trial with seven participants aged between 50 and 69.
It is the first involving implanting stem cells into the brain to cure Parkinson’s.
“I appreciate the patients for participating in the trial with courage and determination,” Kyoto University professor Jun Takahashi told reporters on Friday, according to public broadcaster NHK.
Parkinson’s disease is a chronic, degenerative neurological disorder that affects the body’s motor system, often causing shaking and other difficulties in movement.
Worldwide, about 10 million people have the illness, according to the Parkinson’s Disease Foundation.
Currently available therapies “improve symptoms without slowing or halting the disease progression,” the foundation says.
The human trial comes after an earlier trial involving monkeys.
Researchers announced last year that primates with Parkinson’s symptoms regained significant mobility after iPS cells were inserted into their brains.
They also confirmed that the iPS cells had not transformed into tumors during the two years after the implant.
iPS cells are created by stimulating mature, already specialized, cells back into a juvenile state — basically cloning without the need for an embryo.
The cells can be transformed into a range of different types of cells, and their use is a key sector of medical research.


World’s first female spacewalking team makes history

Updated 18 October 2019

World’s first female spacewalking team makes history

  • NASA astronauts Christina Koch and Jessica Meir exited the International Space Station on Friday

CAPE CANAVERAL, Florida: The world’s first female spacewalking team is making history high above Earth.
NASA astronauts Christina Koch and Jessica Meir exited the International Space Station on Friday, the first time in a half-century of spacewalking that a woman floated out without a male crewmate. Their job is to fix a broken part of the station’s solar power network.
America’s first female spacewalker from 35 years ago, Kathy Sullivan, is delighted. She says it’s good to finally have enough women in the astronaut corps and trained for spacewalking for this to happen.
NASA originally wanted to conduct an all-female spacewalk last spring, but did not have enough medium-size suits ready to go.

When a Saudi went to space
Prince Sultan bin Salman speaks exclusively to Arab News about his 1985 NASA mission and how he became the first Arab, Muslim and royal in space
Enter
keywords