Arthritis drug trialled as potential treatment for COVID-19

The first patient, administered with the drug, is currently being cared for at Manchester Royal Infirmary (MRI), part of Manchester University NHS Foundation Trust (MFT). (Courtesy MFT)
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Updated 28 September 2020

Arthritis drug trialled as potential treatment for COVID-19

  • Dr. Andy Martin: We are conducting this study to see whether otilimab could potentially ease the effect of COVID- 19 on the lungs
  • Dr. Tim Felton: The primary end point of this study is that participants are alive and free of lung failure after 28 days — so this research is potentially life-saving

LONDON: The experimental arthritis drug, otilimab, is being trialled as a potential treatment for COVID-19.

The first patient administered with the drug is currently being cared for at Manchester Royal Infirmary (MRI), part of Manchester University NHS Foundation Trust (MFT).

The OSCAR study (Otilimab in Severe COVID-19 Related Disease) is sponsored and funded by the pharmaceutical company GlaxoSmithKline.

The study at the MRI is being led by Dr. Andy Martin, an Intensive Care and Anaesthesia Consultant.

Dr. Martin said: “The patients eligible to take part in this study are those experiencing very severe lung difficulties due to COVID-19 infection and are receiving oxygen or ventilator support.

“We are conducting this study to see whether otilimab — which is under investigation as a potential treatment for rheumatoid arthritis — could also potentially ease the effect of coronavirus on the lungs, dampening the impact of the virus on the immune system.

Christopher Corsico, GSK's Senior Vice President Development, said: “We are continuing to work hard to find solutions to address the pandemic, including exploring potential treatment options for COVID-19 patients.

“We know that some COVID-19 patients experience an overreaction of their immune system — sometimes referred to as cytokine storm — which can lead to hospitalization or death. We believe that otilimab might be able to help counter or calm this process.

Dr. Tim Felton, honorary consultant, senior lecturer at The University of Manchester and Clinical Lead for all MFT COVID-19-related research studies, leads OSCAR at Wythenshawe Hospital, which is also part of MFT.

Dr. Felton said: “The primary end point of this study is that participants are alive and free of lung failure after 28 days — so this research is potentially life-saving.

“I’d like to thank our first OSCAR participant — as well as the thousands of others who have taken part in coronavirus studies at MFT to date — as every participant who takes part in our research is contributing to the coordinated effort to enhance understanding of this global pandemic.”


Indonesian president ‘honored’ to have UAE street named after him

Updated 22 October 2020

Indonesian president ‘honored’ to have UAE street named after him

  • Abu Dhabi’s Al-Ma’arid Street renamed President Joko Widodo Street

JAKARTA: Indonesian President Joko Widodo on Tuesday said it was “an honor” for him and his country that a street in the UAE capital had been named after him.

Al-Ma’arid Street, one of Abu Dhabi’s key roads, was on Monday renamed President Joko Widodo Street during a ceremony that coincided with the first anniversary of the Indonesian leader’s inauguration for a second term in office.

Writing on social media, Widodo said: “It is a recognition and an honor, not only for me, but for Indonesia.” He also expressed hope that the two countries’ relations would be “stronger, mutually strengthening, and beneficial for the people of the United Arab Emirates and Indonesia.”

Indonesia’s ambassador to the UAE, Husin Bagis, told Arab News: “The initiative to rename the street after President Joko Widodo came from His Highness (Abu Dhabi Crown Prince Sheikh Mohammed bin Zayed Al-Nahyan), who also presided over the street renaming ceremony on the spot.”

The envoy said that the street was near to the future location of the Indonesian Embassy compound, which was currently under construction.

According to UAE news agency WAM, the crown prince has also directed officials to build a mosque named after Widodo, in Abu Dhabi’s Diplomatic Area, in recognition of the Indonesian president’s close friendship with the UAE and his efforts to strengthen the relationship.

Indonesia-UAE relations have grown closer since Widodo’s visit to Abu Dhabi in January, during which he secured investment projects worth $22.9 billion in what has officially been described as the biggest trade deal in the country’s history. The visit was to reciprocate the crown prince’s trip to Indonesia in July 2019.

Recent cooperation agreements between the two countries have included plans for the construction of a mosque on a plot of land in Widodo’s hometown of Solo in Central Java.

The mosque will be a replica of Abu Dhabi’s Sheikh Zayed Grand Mosque and serve as an Islamic center offering training for clerics. A groundbreaking ceremony is slated to take place in December.

Widodo is the latest Indonesian leader to be celebrated through an honorific street name in a foreign country. In Rabat, Morocco’s capital, Avenue Sukarno was named after Indonesia’s first president, while Mohammed Hatta Street in Haarlem, the Netherlands, recognizes the Southeast Asian country’s first vice president. Sukarno and Hatta are considered the fathers of Indonesia’s independence.

The name of the country’s third president, B. J. Habibie, appears on a bridge in Dili, the capital of East Timor, in honor of his decision to hold a referendum there which allowed East Timor to secede from Indonesia.