Conditions in the enclave, the last major rebel-held zone near Damascus and where at least 390,000 civilians have been besieged for four years, amount to a humanitarian catastrophe, Zeid Ra’ad Al-Hussein said.
“Residential areas are being hit day and night by strikes from the ground and from the air, forcing civilians to hide in basements,” he said in a statement.
The UN official said warring parties were obliged by law to distinguish between civilians and lawful military targets, and reports from Eastern Ghouta suggested of the attackers were flouting those principles, “raising concerns that war crimes may have been committed.”
Among the dead civilians were 21 women and 30 children, Al-Hussein said.
Backed by Russian strikes, Syrian regime forces have escalated military operations against Eastern Ghouta in recent months. Russia rejects accusations that its jets have been targeting civilians.
The UN rights chief said failure to evacuate urgent medical cases from the enclave was also against the international humanitarian law.
Armed opposition groups holed up in Eastern Ghouta had also continued to fire rockets into residential areas of Damascus, which he said caused terror among the population.
A rocket landed near a bakery in Old Damascus on Jan. 4, killing a woman and injuring 13 other civilians, he said.