Cecil (2-1) lost the perfect game when he walked Grady Sizemore with one out in the seventh. He then walked Shin-Soo Choo but came back to strike out Austin Kearns before Johnny Peralta lined a 2-2 pitch to left field, scoring Sizemore to get Cleveland within 4-1.

Kevin Gregg gave up a one-out single to Sizemore in the ninth. He walked Kearns with two outs, then fired a called third strike past Peralta on a full count to complete the two-hitter.

Toronto hit three home runs off Mitch Talbot (3-2), giving the Blue Jays an AL-leading 41.

Jose Bautista’s two-run homer put Toronto ahead in the second. Travis Snider hit his fourth of the year in the fourth and John Buck connected for his fourth in the eighth to make it 5-1.

Red Sox 17 Angels 8: In Boston, Dustin Pedroia’s three-run homer capped Boston’s seven-run sixth inning.

Bill Halland Adrian Beltre each hit their first homers in a Red Sox uniform, both two-run shots, and Kevin Youkilis had a solo blast.

Boston snapped a three-game losing streak after getting swept by Baltimore over the weekend.

Clay Buchholz (3-2) gave up four runs and eight hits in 5 2-3 innings.

The Red Sox built a 5-0 lead with three runs in the second and two in the third off Joe Saunders (1-5).

The Angels have lost four straight for the second time this season.

Mike Lowell went 4 for 4 with four RBIs and three doubles for Boston, and J. D. Drew had four hits and drove in three runs.

Maicer Izturis hit a two-run double for Los Angeles.

Yankees 4 Orioles 1: In New York, CC Sabathia pitched eight strong innings and Randy Winn hit a three-run homer to lead New York.

Sabathia (4-1) allowed one run—Matt Wieters’second-inning homer—and six hits while improving to 11-1 in 16 career starts against Baltimore.

Alex Rodriguez singled and scored during a four-run fourth in his return to the lineup after a day off, but catcher Jorge Posadaleft after five innings with right calf tightness. The extent of the injury was unclear, but the Yankees announced he was to undergo an MRI on Monday night.

Joba Chamberlain pitched the ninth for his first save this season.

Jeremy Guthrie (0-4) pitched seven innings of six-hit ball.

Nick Swisher went 3 for 3 for New York.

Twins 10 Tigers 4: In Minneapolis, Wilson Ramos had three more hits in Joe Mauer’splace and Michael Cuddyeradded a three-run homer and Minnesota snapped Detroit’s five-game winning streak.

Ramos had two doubles and an RBI and Scott Baker (3-2) allowed three runs and seven hits with six strikeouts in seven innings for the Twins.

Detroit starter Max Scherzer (1-2) gave up 10 runs and eight hits with four walks in 4 1-3 innings.

Austin Jacksonhad three hits to raise his average to .377, but the Twins were up 7-0 after two innings against Scherzer, who has given up 18 hits and 16 runs in his last two starts against Minnesota.

Mauer missed his third straight game with a bruised left heel. Ramos was called up to play against Cleveland on Sunday and became the first catcher in modern baseball history (since 1900) to collect four hits in his major league debut, according to the Elias Sports Bureau.

He had an RBI-double in Minnesota’s three-run fifth inning that put the game out of reach at 10-3 and has seven hits in his first nine at-bats.

White Sox 5 Royals 1: In Chicago, Jake Peavy pitched seven-plus shutout innings in his most impressive start of the season and Alex Rios had three hits and two RBIs for Chicago.

Peavy (1-2) struck out a season-high nine and gave up four hits. He didn’t allow a hit until Mitch Maier singled with two outs in the fifth.

Ramirez hit a solo home run and Andruw Jones had two hits and two RBIs for the White Sox, who began a seven-game homestand after finishing a 2-4 road trip Sunday.

Scott Podsednik homered against his former team in the ninth inning off reliever Scott Linebrink, snapping a 17-inning scoreless streak for the Royals.

Gil Meche(0-3) allowed five runs and nine hits in five innings for the Royals.

Rangers 4 Athletics 2: In Oakland, Calif., Rich Harden struck out a season-high nine in seven scoreless innings and dominated his former team as first-place Texas won its season-best fourth straight.

Harden (2-1), who spent his first 5 1/2 big league seasons with the A’s, didn’t allow a hit until Rajai Davis’one-out double in the sixth. He gave up two hits in all and didn’t walk a batter for the first time in his six starts.

Justin Smoakhomered, Michael Younghad an RBI double, Josh Hamiltonsingled in a run and Ryan Garkoadded an RBI groundout in the Rangers’ fifth straight road win.

The dismal crowd of 8,874 was the A’s lowest since they drew 6,295 against Seattle on April 3, 2003.