Miguel Tejada added two RBIs for the defending World Series champions, who had committed five errors in dropping a pair of one-run games to the rival Dodgers. But they backed Cain with ample offense and clean defense to avoid equaling their worst start since moving to San Francisco in 1958.

Cain (1-0) struck out three and walked none, picking up where he left off last season as one of the Giants’ most consistent starters.

Ted Lilly (0-1) gave up four runs and six hits in 4 2-3 innings, struck out three and walked one for the Dodgers.

Phillies 9 Astros 4: In Philadephia, Cliff Lee struck out 11 over seven impressive innings in his first game back with the Phillies.

A day after rallying against closer Brandon Lyon for a comeback win in the ninth, the Phillies roughed up starter Wandy Rodriguez .

The victory might be costly to the Phillies because center fielder Shane Victorino left with soreness in his left calf.

Lee (1-0) allowed three runs and four hits.

Padres 11 Cardinals 3: In St. Louis, Clayton Richard (1-0) had two RBIs to match his career high without getting the ball out of the infield and pitched six solid innings for San Diego.

Albert Pujols homered on the 10th anniversary of his major league debut and Allen Craig, subbing for ailing Matt Holliday , had a two-run single for the Cardinals.

Nationals 6 Braves 3: In Washington, Rick Ankiel drove in three runs with a homer and squeeze bunt, Jayson Werth and Wilson Ramos each had three hits and the Nationals beat Atlanta.

In a game that included two rain delays totaling 87 minutes, Ankiel’s two-run homer run highlighted a three-run third inning off Tommy Hanson (0-1). Ankiel put down his bunt in the seventh.

Cubs 5 Pirates 3: In Chicago, Pinch-hitter Blake DeWitt delivered a two-out, two-run double that capped a five-run eighth inning Saturday as the Cubs rallied for a win.

Chicago’s comeback against relievers Evan Meek (0-1) and Chris Resop was aided by a costly error on Pirates first baseman Lyle Overbay .

Reds 4 Brewers 2: In Cincinnati, Scott Rolen hit a two-run homer in the first inning, eliminating the need for another dramatic Cincinnati comeback, and the Reds beat Milwaukee behind seven strong innings from left-hander Travis Wood .
 
AMERICAN LEAGUE

Yankees 10 Tigers 6: In New York, A.J. Burnett took a steady first step as he aims to bounce back from a wobbly season and Mark Teixeira hit his second three-run homer in two games, sending the New York Yankees to a 10-6 victory over the Detroit Tigers on Saturday.

Russell Martin also smacked a three-run shot, Alex Rodriguez hit No. 614 and Derek Jeter began his march toward 3,000 hits with his first two of the season.

Rodriguez drove in Jeter with a first-inning double off Brad Penny (0-1), an early bust in his Detroit debut, and New York opened a 6-0 cushion after two. Burnett (1-0), fighting a bad head cold this week, was in control from the start and made it through five effective innings.

Blue Jays 6 Twins 1: In Toronto,  Kyle Drabek pitched seven innings of one-hit ball to earn first major league win, and Jose Molina and Jayson Nix hit solo home runs for Toronto.

Drabek (1-0) didn’t allow a hit until Denard Span’s one-out single to left in the sixth. He allowed one run, walked three and struck out a career-high seven.

Orioles 3 Rays 1: In St. Petersburg, Florida, Chris Tillman held Tampa Bay hitless for six innings and Nick Markakis made a leaping catch at the wall in the ninth to preserve the win for Baltimore.

Tillman lost his bid for a no-hitter when manager Buck Showalter lifted him after the 22-year-old right-hander threw 101 pitches. B.J. Upton lined a two-out single off Jeremy Accardo (1-0) for Tampa Bay’s first hit with two outs in the seventh.

White Sox 8 Indians 3: In Cleveland, Edwin Jackson extended his mastery of Cleveland, and Gordon Beckham and Carlos Quentin had two RBIs apiece for Chicago.

Jackson, 8-0 in his last nine starts against Cleveland, allowed two earned runs and five hits in six innings. He had one shaky frame, and that wasn’t all his fault as two errors on one play by third baseman Brent Morel helped the Indians score two in the second.

Royals 5 Angels 4: In Kansas City, Missouri, Chris Getz had three hits, including an RBI single for the go-ahead run in the eighth inning to help Kansas City rally.

Rookie Aaron Crow (1-0) pitched 1 2-3 innings for the victory, his first as a major leaguer. Kevin Jepsen (0-1) took the loss as the Angels’ bullpen faltered for the third straight day.

Mariners 5 Athletics 2: In Oakland, California, Ichiro Suzuki had two infield hits to become Seattle’s career leader, including a bouncer in the ninth that drove in the go-ahead run.

Suzuki reached on an infield single in the third, then did it again with his record-breaking hit off Brian Fuentes (0-1) that drove in Jack Wilson and made it 3-2 Mariners.