With a full house cheering from the pre-game player introductions, the Red Sox pounded 12 hits, three by Pedroia. They started the season on the road by going 0-6 for the first time since beginning the 1945 season at 0-8.

They were a popular preseason choice to reach the World Series after adding Carl Crawford and Adrian Gonzalez to support what seemed like a strong rotation. But the struggles of the starters continued when John Lackey (1-1) gave up six runs in five innings.

He still got the win when Jarrod Saltalamacchia's run-scoring double broke off Bartolo Colon (0-1) a 6-6 tie in the fifth.

At Minneapolis, Joe Mauer and Denard Span delivered RBI singles in the eighth inning against the superb Brett Anderson to lift the Twins to a victory over Oakland Athletics in their home opener.

Joe Nathan recorded his first save at Target Field after missing all of last season while recovering from elbow surgery.

Carl Pavano (1-1) gave up one run on four hits in eight innings to get the win.

Anderson (0-1) gave up two runs on eight hits and struck out five in eight innings for the Athletics.

At Detroit, Victor Martinez hit a three-run double in his first home at-bat for the Tigers, helping his new team to a win over Kansas City.

Martinez, who signed with Detroit in November, cleared the bases in the first inning with a drive to the gap in right-center field. Jhonny Peralta drove in two runs for the Tigers, who looked sharp in their home opener after losing four of six to start the season.

Max Scherzer (2-0) allowed one run on seven hits in six innings. The Tigers took advantage of an erratic outing by Kyle Davies (0-1), who allowed five runs on six hits in 3 2-3 innings.

At Chicago, Dan Johnson hit a three-run homer to cap a five-run ninth, and Tampa Bay rallied for their first win of the season hours after Manny Ramirez retired.

The dramatic comeback ended a wild day in which Ramirez decided to call it quits rather than face a 100-game suspension for violating baseball's drug policy for the second time.

The Rays appeared to be on their way to another loss after dropping their first six games, but that changed in a hurry in the ninth.

Matt Thornton (0-1) was the loser, blowing his second save in two chances.

At Anaheim, California, Jayson Nix hit a tiebreaking two-out homer in the eighth inning, and the Toronto Blue Jays spoiled the Angels' home opener.

Adam Lind hit a tying two-run double in the sixth inning for the Blue Jays, who improved to 5-2 after Ervin Santana (0-1) held them hitless into the fifth.

Vernon Wells had a forgettable home debut against the club that traded him to the Angels last winter, stranding five runners while going 0 for 4 with four inning-ending outs.

After rookie Kevin Drabek allowed six hits over six innings for Toronto, Octavio Dotel (1-0) pitched a hitless seventh, and Jon Rauch pitched the ninth for his second save.

At Seattle, Travis Hafner had an RBI single and hit a three-run homer that nearly reached the third-deck of seats as part of Cleveland's 10-run fourth inning, and the Indians won their fifth straight.

Carlos Carrasco (1-1) gave up one run and four hits in six innings.

Starting with Shin-Soo Choo, the first five Indians in the fourth inning had hits against Jason Vargas (0-1).

It was Cleveland's first 10-run inning since a franchise-record 14 runs scored in one inning against the Yankees in 2009.

It was the worst home-opening loss in Mariners history.