Neymar also missed a late penalty as Santos drew 1-1 against Colombia’s Once Caldas to progress 2-1 on aggregate, while Maximiliano Moralez scored twice as Velez won 4-2 at Paraguay’s Libertad for a 7-2 aggregate victory.

Santos will next face either Chiapas of Mexico or Paraguay’s Cerro Porteno. Chiapas and Cerro drew 1-1 in Mexico.

Velez will take on the winner of the quarterfinal between Uruguay’s Penarol and Chile’s Universidad Catolica. Penarol has a 2-0 lead ahead of the return in Chile.

The remaining two quarterfinals will be played on Thursday.