Wednesday’s action freezes any assets in the United States belonging to Abu Yahya Al-Libi; Abd Al-Rahman Ould Muhammad Al-Husayn Ould Muhammad Salim; and Mustafa Haji Muhammad Khan. Americans are also barred from doing business with the men.

David S. Cohen, the undersecretary of treasury for terrorism and financial intelligence, says the sanctions strike “at the heart of Al-Qaeda’s remaining leadership and its operations in Pakistan.”

The Treasury Department identified Al-Libi as an Al-Qaeda commander, Salim as a senior leader of the terrorist organization and Khan as a facilitator, courier and operative.