A week after throwing for 422 yards, Newton topped himself by throwing for 432 yards and a touchdown. He also ran for a 4-yard touchdown with 37 seconds left to bring Carolina (0-2) within seven, but the Packers (2-0) recovered the onside kick to seal the victory.

Rodgers found Greg Jennings for a 49-yard touchdown early in the third quarter to put the Packers ahead for good. Then, after Clay Matthews stopped Newton on a fourth-down run inside the 5, Rodgers found Jordy Nelson for an 84-yard touchdown to make it a two-possession game and help the Packers hang on.

In Indianapolis, Peyton Hillis ran for 94 yards and two touchdowns, Colt McCoy threw for 211 yards and a score and Cleveland ended a five-game losing streak against Peyton Manning-less Indianapolis.

The Colts are 0-2 for the first time since 1998, and Manning likely will miss two months following his third neck surgery in 20 months. 

In Atlanta,  Matt Ryan threw a career-high four touchdown passes and the Falcons rallied to beat the Eagles after Michael Vick was knocked out with an injury late in the third quarter.

Ryan hit Tony Gonzalez with a pair of TDs, the tight end going past Terrell Owens for fifth on the NFL’s career receiving list. Then, Ryan hooked up with Ovie Mughelli on a 1-yarder that brought Atlanta to 31-28 with just over 6 minutes remaining.

In New Orleans, Drew Brees threw for three touchdowns and New Orleans’ defense beat up on Jay Cutler.

Brees’ scoring strikes included a 79-yarder to Devery Henderson. Darren Sproles scored on a 12-yard swing pass and Robert Meachem had a 4-yard TD reception as the Saints (1-1) bounced back from an opening week loss to Green Bay.

In Orchard Park, New York, Ryan Fitzpatrick threw a 6-yard touchdown pass to David Nelson with 14 seconds left to cap a wild back-and-forth fourth quarter.

The Bills scored touchdowns on all five of their second-half possessions to overcome a 21-3 first-half deficit. The teams traded leads five times over the final 14:10.

Fred Jackson scored twice and had 117 yards rushing for the Bills (2-0) in their home opener. Fitzpatrick finished 28 of 46 for 264 yards and three touchdowns.

In Foxborough, Massachusetts, Tom Brady threw for 423 yards six days after setting a single-game team record of 517 in leading New England.

Brady had three touchdown passes and tied for the third most yards passing in club history, going 31 of 40 with no interceptions as the Patriots (2-0) scored on each of their four first-half possessions.

In San Francisco, playing with a fractured rib, Tony Romo hit Jesse Holley on a 77-yard completion in overtime to set up Dan Bailey’s winning 19-yard field goal for Dallas.

Bailey kicked a tying 48-yard field goal as time expired in regulation after missing an early 21-yard attempt.

In Landover, Maryland, Graham Gano kicked a 34-yard field goal with 1:45 remaining as Washington rallied from an eight-point, fourth-quarter deficit.

The Redskins (2-0) beat the Cardinals (1-1) for the eighth time in a row. Santana Moss’ 18-yard catch on fourth down with 5:17 remaining pulled Washington within two, but the 2-point conversion attempt failed.

In Pittsburgh, Ben Roethlisberger threw for 298 yards and a touchdown as the Steelers put their opening week loss to Baltimore behind them.

Mike Wallace caught eight passes for 126 yards and a score and Rashard Mendenhall ran for 67 yards and a touchdown for the Steelers (1-1), who limited the listless Seahawks (0-2) to 164 total yards.

A week after committing seven turnovers while getting whipped by rival Baltimore, the Steelers worked with relentless efficiency against Seattle. Roethlisberger shook off a gimpy right knee to complete 22 of 30 passes, and the defense kept Seattle from taking an offensive snap on Pittsburgh’s side of the field until midway through the fourth quarter.

In Nashville, Tennessee, Matt Hasselbeck threw for 358 yards and a touchdown, and Tennessee gave new coach Mike Munchak a big win in the home opener.

With the Ravens (1-1) focused on stopping Chris Johnson, Hasselbeck attacked through the air. Kenny Britt caught nine passes for 135 yards and a TD, while Nate Washington caught seven passes for 99 yards. 

In Detroit, Matthew Stafford threw two of his four TD passes to Calvin Johnson and Detroit came away with its largest margin of victory in a regular season game.

The Lions broke the mark they set with a 44-0 win over expansion Jacksonville in 1995 and matched the record set in the 1957 NFL title game when they beat Cleveland 59-14.

In Miami, Andre Johnson caught a 23-yard touchdown pass from Matt Schaub that helped Houston get off to s 2-0 start.

Miami’s sieve-like pass defense was no match for Johnson and Schaub, who threw for 230 yards and had a quarterback rating of 118.5. Johnson made seven catches for 93 yards.

The Dolphins committed two turnovers, had a 22-yard field-goal attempt blocked and missed a 34-yarder. 

In Minneapolis, LeGarrette Blount’s 4-yard touchdown run with 31 seconds left lifted Tampa Bay and completed another comeback by quarterback Josh Freeman — this time from a 17-0 halftime deficit.

Eight of Freeman’s 14 career victories have come when the Bucs (1-1) went ahead in the fourth quarter or overtime. Given how overwhelmed they were before halftime, outgained 284 yards to 62 during the first two quarters, this might have been the most impressive.

In East Rutherford, New Jersey, Mark Sanchez threw two touchdown passes as the offense started quickly and Antonio Cromartie had two of New York’s four interceptions of Luke McCown.

After having not scored an offensive TD in the first quarter in 16 games, the Jets (2-0) won the toss, elected to receive — a rarity under the defensive-minded Rex Ryan — and scored on a 17-yard catch by Santonio Holmes.

In Denver, Kyle Orton threw two TD passes to Eric Decker , Willis McGahee ran for another score and John Fox gained his first win as Denver’s coach.

The Broncos (1-1) lost two more players to injury — giving them nine, including six starters — but still topped the Bengals (1-1) for the ninth straight time in Denver, where Cincy hasn’t won since 1975.