LOS ANGELES: A return to California proved to be just what Andrew Luck needed as the Indianapolis quarterback led the Colts to a 27-7 rout of the San Francisco 49ers on Sunday.

Luck, who starred at nearby Stanford University during his US college football career, completed 18-of-27 passes for 164 yards and ran for a touchdown as he won the battle of the young quarterbacks by outplaying San Francisco’s Colin Kaepernick.

“That was a heavyweight fight right there,” Colts head coach Chuck Pagano said. “Just a phenomenal, phenomenal effort.”

Luck got some assistance as the Colts also clamped down on the defense by holding the 49ers to 254 total yards.

Indianapolis improved to 2-1 on the National Football League season. They compiled 179 rushing yards, with Ahmad Bradshaw gaining 95 and a touchdown on 19 carries, and the newly acquired Trent Richardson scoring on his first touchdown as a Colt.

One week after suffering four turnovers in a 29-3 loss at Seattle, Kaepernick managed just 150 yards on 13-of-27 passing while being intercepted once and losing a fumble.

“We have to be better,” Kaepernick said. “I have to be better. I have to be able to make throws down the field.”

In Miami, Ryan Tannehill threw his second touchdown pass with 38 seconds remaining in the fourth quarter, giving Miami a 27-23 win over the Atlanta Falcons in the Dolphins’ home opener.

Atlanta kicker Matt Bryant missed a 35-yarder wide right that would have given the Falcons a six-point lead with 4:46 to play.

Tannehill then led the Dolphins on a 13-play drive that ended with Dion Sims’ one-handed catch from a yard out.

“I didn’t really think about the situation, everything was just instinctive,” Sims said. “The linebacker grabbed my arm so I just reached up with my free arm and brought it in.”

Miami safety Jimmy Wilson picked off Atlanta quarterback Matt Ryan to ice the victory.

Terence Newman returned a fumble 58 yards for the go-ahead touchdown with 3:47 remaining and the Cincinnati defense came up with one more stop of Aaron Rodgers, as the Bengals rallied for a 34-30 win over the Green Bay Packers in a wild contest at Paul Brown Stadium.

The Bengals stormed out to a 14-0 lead before four consecutive turnovers allowed the Packers to claw their way back into it. The Packers scored 30 consecutive points before Cincinnati came back with the last 20, including 13 in the fourth quarter to win it.

Seattle quarterback Russell Wilson matched a career high with four touchdowns passes and the Seahawks crushed the Jacksonville Jaguars 45-17 at CenturyLink Field.

Wilson completed 14-of-21 passes for 202 yards and an interception, with Zach Miller and Sidney Rice each catching two of Wilson’s touchdown tosses.

Enter backup quarterback Tarvaris Jackson with the game in hand, and he threw for a touchdown and ran for another in the win.