Stephen Garcia threw three touchdown passes, two to Alshon Jeffrey, and Marcus Lattimore scored three times as 19th-ranked South Carolina stunned top-ranked Alabama 35-21 on Saturday.

In Ann Arbor, Michigan State intercepted three of Denard Robinson’s passes and the 17th-ranked Spartans beat No. 18 Michigan 34-17.

The defending national champion Crimson Tide had won 19 straight games — including last week’s 31-6 rout of Florida — since losing the Sugar Bowl after the 2008 season to Utah. The Gamecocks (4-1, 2-1 Southeastern Conference) had never beaten a No. 1 team in four previous tries.

“We played some ball today,” Spurrier said. “We played until the end, looked up and we’d beaten number one by a couple of touchdowns. Hopefully, it was something we can build on.”

The Head Ball Coach, in his sixth season at South Carolina, had the players to beat Alabama using the Tide’s own formula.

Garcia and the Gamecocks cashed in on chances when they got close to the goal line and shut down the best tailback duo in the country, making themselves a factor in the SEC title chase. They could run into the Tide again at the SEC championship game in Atlanta.

“I actually talked to (Greg) McElroy after the game and he said, ‘We’ll see you all again,”’ said Garcia, who was pulled from South Carolina’s last game, a 35-27 loss at Auburn, after fumbling twice.

Playing at home, South Carolina shredded the country’s top-rated scoring defense, putting up the most points on Alabama (5-1, 2-1) since a 41-34 loss to LSU in 2007. The Gamecocks scored four touchdowns when they got inside the ‘Bama 20 - double what the Crimson Tide had allowed coming in.

Alabama’s Mark Ingram and Trent Richardson were held to 64 yards on the ground as the Crimson Tide tried to rally back, just as it had in beating Arkansas 24-20 two games ago.

No. 2 Ohio State beat Indiana 38-10 in Columbus and the Buckeyes are likely to become the No. 1 team in the nation when the AP Top 25 comes out Sunday. Ohio State was last No. 1 in the final AP poll of the 2007 regular season, when the Buckeyes lost the BCS championship game to LSU.

Up in Ann Arbor on Saturday, Michigan State scored 24 unanswered points to break open a close game at the big House. Michigan State coach Mark Dantonio made the trip nearly three weeks after having a mild heart attack.

The Spartans (6-0, 2-0 Big Ten) trailed midway through the second quarter before their scoring binge, which allowed them to beat their rivals for the third straight time. It’s their longest winning streak over the Wolverines since 1965-67.

As expected, Michigan (5-1, 1-1) struggled to stop Michigan State, but both teams had to be stunned by Robinson’s inability to make many plays with his arm or his feet.

Michigan State’s Kirk Cousins threw for a touchdown and Edwin Baker, Le’Veon Bell and Larry Caper ran for one each, giving Dantonio a reason to smile. He was back coaching from a box high above the field.

The Spartans seemed to rattle Robinson, intercepting a pass in the end zone on the opening drive of the game and picking off a third pass after he scored to pull Michigan within two TDs on the first play of the fourth quarter.

No. 3 Oregon 42  Washington State 23: In Pullman, Washington, LaMichael James scored three touchdowns, including an 84-yard scoring reception, and Oregon shook Washington State in the second half.

Coming off a big home win over Stanford that flew the Ducks past Boise State in the AP Top 25, Oregon struggled to make just enough plays to hold off the pesky Cougars. But whether it was enough for the Ducks to hold their spot in the polls remains to be seen. Oregon (6-0, 3-0) was a 36-point favorite, yet led just 36-23 late in the third quarter.

Backup quarterback Nate Costa played the final three quarters for Oregon after Darron Thomas left with an apparent shoulder injury. Costa led three scoring drives and ran for an 18-yard touchdown.

No. 4 Boise State 57  Toledo 14: In Boise, Idaho, Jeremy Avery ran for three touchdowns, Kellen Moore passed for three more and the defense forced four turnovers.

Moore and the rest of the offense were clicking from the start, scoring on five of their first seven possessions to put the game out of reach early. Boise State (5-0) has now won 19 straight games, the nation’s longest winning streak after top-ranked Alabama was upset by No. 19 South Carolina.

Moore was efficient as usual, connecting on 16 of 22 passes for 267 yards, including a 51-yard touchdown to Titus Young. Avery scored twice on 5-yard runs and another on a 12-yard reverse.

No. 5 TCU 45 Wyoming 0: In Forth Worth, Texas, Andy Dalton threw for a season-high 270 yards and three touchdowns a week after his worst game of the season and TCU recorded consecutive shutouts for the first time in 55 years.

Dalton was 14 of 17 and surpassed last week’s passing total on the first play of the second quarter, a 31-yard strike to Bart Johnson that put the Horned Frogs (6-0, 2-0 Mountain West) ahead 21-0.

Wyoming (2-4, 0-2 Mountain West) had to go with backup quarterback Dax Crum because the injured

No. 8 Auburn 37 Kentucky 34: In Lexington, Kentucky, Cam Newton drove Auburn into position for Wes Byrum’s 24-yard field goal as time expired.

Newton ran for a career-high 198 yards and four touchdowns and deftly guided the Tigers (6-0, 3-0 Southeastern Conference) 88 yards in the final 7:22 after the Wildcats tied it at 34.

Oregon State 29  No. 9 Arizona 27: In Tucson, Arizona, Oregon State’s Ryan Katz threw for 393 yards and two touchdowns, and sneaked across for another score.

The sophomore from Santa Monica, California, completed 30 of 42 against an Arizona defense that had been ranked No. 2 nationally, giving up 230.8 yards per game.

No. 10 Utah 68  Iowa State 27: In Ames, Iowa, Jordan Wynn threw for 325 yards and two touchdowns and Shaky Smithson threw a TD pass and caught another one for Utah.

Eddie Wide added three touchdowns for the Utes (5-0, 2-0 MWC), who scored 31 unanswered points in the second quarter and racked up their most points since beating Wyoming 69-14 in 1983.

Smithson, a wide receiver, gave the Utes a 17-14 lead with a 32-yard touchdown pass. Matt Asiata and Wide followed with short TD runs, and Wynn found Smithson for a 61-yard touchdown to make it 38-14 late in the first half.

No. 11 Arkansas 24  Texas A&M 17: In Arlington, Texas, Ryan Mallett threw three touchdown passes in the first half for Arkansas and Tramain Thomas sealed the victory at Cowboys Stadium with an interception in the end zone on the final play.

The Razorbacks (4-1) failed to take advantage of three fumbles recovered inside the Aggies’ 40. They got just one field goal out of the turnovers.

Mallett threw a 9-yard touchdown pass to Joe Adams on his first series and hit Cobi Hamilton on a pinpoint 71-yard touchdown pass for another score later in the first quarter. When he stretched the lead to 21-7 with 53 seconds left.

No. 12 LSU 33 No. 14 Florida 29: In Gainesville, Florida,  Jarrett Lee tossed a 3-yard touchdown pass to Terrence Tolliver with 6 seconds left after LSU kept its final drive alive with a successful fake field goal, and the Tigers pulled out another wild victory.

With 35 seconds remaining, LSU (6-0, 4-0) lined up for a game-tying, 52-yard field goal, but holder Drew Alleman threw a no-look pitch over his head to place-kicker Josh Jasper. The ball bounced, Jasper scooped it up on a hop and ran for the first down.

No. 23 Florida State 45 No. 13 Miami 17: In Miami, Jermaine Thomas scored a career-high three touchdowns, Chris Thompson rushed for 158 yards and Florida State ran out to a huge lead on the way to beating Miami.

Thomas had touchdown runs of 1 and 6 yards, plus caught a 17-yard scoring pass from Christian Ponder - all in the game’s first 21 minutes for the Seminoles (5-1, 3-0 Atlantic Coast Conference).