With the Steelers (4-1) leading 7-3 but backed up to their own 4 late into the third quarter, Roethlisberger — flashing the big-play ability his team lacked without him — completed passes of 50 yards to Mike Wallace and 36 yards to Heath Miller on successive plays.

Three plays later, Hines Ward fought through two potential tacklers on an 8-yard touchdown catch that made it 14-3 and gave the Steelers’ defense all the points needed on a mostly dominating day. The Browns (1-5) never advanced inside the 20 until rookie Colt McCoy’s late 12-yard scoring pass to Ben Watson with Pittsburgh already up by 18 points.The Browns fell to 1-5.

Browns wide receivers Joshua Cribbs and Mohamed Massaquoi were knocked out of the game in the second quarter after taking hard hits from linebacker James Harrison.

At Philadelphia, Jeremy Maclin and DeSean Jackson each scored two touchdowns as Philadelphia snapped Atlanta’s four-game winning streak.

A head-on collision in the second quarter cost Philadelphia star receiver Jackson, and Atlanta lost cornerback Dunta Robinson, both with head injuries. Jackson dropped a pass when hit by Robinson, who led with his head and hit Jackson in the helmet. Robinson was flagged for hitting a defenseless receiver.

At Foxborough, Massachusetts, Stephen Gostkowski’s 35-yard field goal with 1:56 left in overtime gave New England a come-from-behind win.

Deion Branch, acquired five days after Randy Moss was traded to Minnesota on Oct. 6, sparked the comeback from a 20-10 deficit starting with a 5-yard scoring pass from Tom Brady four minutes into the fourth quarter. The Patriots then forced the Ravens to punt and marched from their 14 to a third down at the Baltimore 3 and settled for Gostkowski’s 24-yard tying field goal.

At Denver, LaDainian Tomlinson scored his second touchdown from 2 yards out with 73 seconds left after a pass interference flag and New York rallied past Denver.

On fourth-and-6 from the Denver 48, Denver safety Renaldo Hill and Jets receiver Santonio Holmes jostled near the goal line and the ball fell incomplete as the crowd went crazy. But field judge Gary Cavaletto threw his yellow flag and called Hill for pass interference.

At Minneapolis, Percy Harvin’s 95-yard kickoff return for a touchdown gave Minnesota a spark to start the second half, as the Vikings overcame another uneven game by Brett Favre in a victory over Dallas.

Playing with a bad elbow and the specter of a scandal hovering over him, Favre — who is to meet with NFL security Tuesday about the alleged racy messages he sent to a former New York Jets employee — finished 14 for 19 for 118 yards, one TD and one turnover.

At East Rutherford, New Jersey, Eli Manning threw two touchdown passes and the Giants sent error-prone Detroit to an NFL record-tying 24th straight road loss.

Safety Deon Grant preserved the third straight win for the Giants (4-2) by forcing and recovering a fumble by Lions’ receiver Nate Burleson at the Giants 42 with about five minutes to go and New York ahead by four points.

At St. Louis, James Hall, Chris Long and Larry Grant had two sacks each as St. Louis shut down the NFL’s top offense for its third straight win at home.

Sam Bradford threw a 38-yard touchdown pass to fellow rookie Danario Alexander, making his NFL debut, to help build a 14-point cushion in the first half. Steven Jackson, who finished with 109 yards, also scored and had several key late carries for the Rams (3-3).

At Houston, Matt Schaub threw an 11-yard touchdown pass to Andre Johnson with 28 seconds left to give Houston a stunning fourth-quarter comeback victory.

The Texans (4-2) trailed 31-21 with just over 7 minutes left after Thomas Jones’ 11-yard TD run. Schaub threw two long passes to Owen Daniels before Arian Foster scored with 3:30 left to cut the Chiefs’ lead to 3.

Matt Cassel threw three TD passes for Kansas City (3-2).

At Tampa, Florida, Drew Brees threw for 263 yards and three touchdowns as New Orleans downed Tampa Bay.

The Super Bowl champions rebounded from a mistake-filled road loss, scoring on their first three possessions and getting an unexpected lift from rookie running back Chris Ivory.

Dolphins 23 Packers 20 OT: At Green Bay, Wisconsin, Dan Carpenter kicked a 44-yard field goal with 9:01 left in overtime to lift Miami past Green Bay.

It was the second straight overtime loss for the injury-riddled Packers (3-3), who lost at Washington last week.

At Chicago, Matt Hasselbeck threw for a season-best 242 yards and a touchdown and Seattle’s defense sacked Jay Cutler six times in a win over Chicago.

Cutler was in trouble much of the game, and completed just 17 of 39 for 290 yards. He missed last week’s game with a concussion after being sacked nine times by the Giants the previous week.

At San Francisco, Alex Smith threw second-half touchdown passes to Michael Crabtree and Vernon Davis as San Francisco finally won its first game, beating Oakland.

Crabtree made a go-ahead 32-yard TD reception on the last play of the third quarter and Smith hit Davis on a 17-yard score with 7:14 remaining.

At Landover, Maryland, Peyton Manning threw for 307 yards and two touchdowns to lead Indianapolis over Washington.

Manning completed 25 of 38 passes, with scoring throws of 57 yards to Pierre Garcon and 5 yards to Austin Collie.

Joseph Addai ran for 128 yards and a touchdown for the Colts before leaving with a shoulder injury.