Adrian Peterson rushed for 107 yards and three touchdowns on a tender right ankle for the Vikings, who have won both matches under interim head coach Leslie Frazier to improve their win-loss record to 5-7.

Favre said he sprained his throwing shoulder, which occurred on the first series of the game after a big hit by Bills linebacker Arthur Moats. Jackson came in and led the Vikings to 31 first-half points. But he also threw three interceptions, including one that Drayton Florence returned 40 yards for a touchdown.

At Baltimore, Ben Roethlisberger threw a 9-yard touchdown pass to Isaac Redman with 2:51 left after Troy Polamalu forced a fumble as Pittsburgh beat Baltimore to gain sole possession of first place in the AFC North.

A fierce defensive battle turned when Polamalu hit Joe Flacco's arm on a safety blitz. The loose ball was taken 19 yards by Lamarr Woodley to the Baltimore 9, setting up Pittsburgh's lone touchdown.

At Indianapolis, Peyton Manning had two interceptions returned for touchdowns and his fourth of the day set up David Buehler for a 38-yard field goal that gave Dallas the win in overtime.

Manning finished 36 of 48 for 365 yards with two touchdowns and his second straight four-interception game.

He's thrown a career-high 11 picks in the past three weeks with four of those going back for TDs.

Dallas (4-8) rushed for a season-high 217 yards and led most of the way thanks to Manning's miscues. The Colts (6-6) fell one game behind first-place Jacksonville in the AFC South.

At Nashville, Maurice Jones-Drew ran for a career-best 186 yards and Rashad Jennings and David Garrard each ran for a touchdown for Jacksonville.

The win allowed the Jaguars (7-5) to take over first-place in the AFC South.

Tennessee (5-7) started veteran Kerry Collins at quarterback, but the Titans were unable to avoid their fifth straight loss. The Titans have now gone 13 quarters without scoring a touchdown.

At Tampa, Eric Weems scored from a 102-yard kickoff return and Matt Ryan threw a 9-yard touchdown pass to Michael Jenkins as Atlanta rallied from a 10-point deficit for its sixth straight victory.

Ryan led his sixth fourth-quarter comeback of the season for the NFC South leaders, keeping a 10-play, 67-yard march alive with a 25-yard completion to Roddy White on third-and-20. The Falcons (10-2) also benefited from a couple of costly penalties on the Bucs.

Rookie LeGarrette Blount rushed for 103 yards and fullback Earnest Graham threw a 2-yard touchdown pass to John Gilmore for Tampa Bay (7-5), which fell to 0-5 against teams with winning records.

At Kansas City, Jamaal Charles rushed for 116 yards and Matt Cassel threw a 3-yard pass to Leonard Pope for the only touchdown as Kansas City avenged a 20-point loss to Denver three weeks ago.

Knowshon Moreno rushed for 161 yards for the Broncos (3-9), who are enduring one of their worst stretches in decades, losing 17 of their past 22 games under coach Josh McDaniels.

In spite of all their blunders, the Chiefs (8-4) stayed unbeaten in six home games and remained on top of the AFC West.

At Seattle, Marshawn Lynch rushed for a career-high three touchdowns, Lofa Tatupu returned an interception 26 yards and Seattle used a 21-point third quarter to rally past Carolina.

Lynch scored on a pair of 1-yard runs in the third quarter, sandwiched around Tatupu's interception of Carolina rookie Jimmy Clausen.

At Glendale, Steven Jackson ran for 102 yards, including 27 on the game's lone touchdown, and Josh Brown kicked four field goals as St. Louis (6-6) won consecutive road games for the first time in more than three years.

At San Diego, Jason Campbell ran for one touchdown and threw for another, while Darren McFadden ran for 97 yards and a TD for Oakland.

The loss puts a serious crimp in the playoff hopes for the four-time defending AFC West champion Chargers (6-6), who trail the Chiefs by two games with four to play. Oakland (6-6) revived a running game that had been stopped cold in two straight losses, ripping through the Chargers for 251 yards.

At Cincinnati, Drew Brees threw a 3-yard touchdown pass to Marques Colston with 31 seconds left, rallying New Orleans to its fifth straight victory.

The Saints (9-3) trailed for the first time after newcomer Clint Stitser made a 47-yard field goal with 4:25 to go, putting the Bengals (2-10) up 30-27.

Plenty of time for Brees to pull it out, with the help of yet another Bengals blunder.

Brees passed Archie Manning as the Saints' career passing leader earlier in the game. His 42-yarder to Robert Meacham got New Orleans into field-goal range.

At Green Bay, Donald Driver's catch-and-run for a 61-yard touchdown broke open a tight game in the third quarter.

Greg Jennings caught six passes from Aaron Rodgers for 122 yards and a pair of touchdowns for the Packers (8-4), who picked up a critical win as they try to make a push for the playoffs in the final month of the season.

At East Rutherford, Brandon Jacobs and Ahmad Bradshaw ran for two touchdowns apiece and New York won easily.

Jacobs ran eight times for 103 yards and scored on jaunts of 8 and 28 yards, while Bradshaw had 97 yards and TD runs of 4 and 10 yards as the Giants (8-4) moved back into first-place tie with Philadelphia in the NFC East.

At Detroit, Jay Cutler threw a go-ahead touchdown pass to Brandon Manumaleuna one play after a questionable call midway through the fourth quarter to lift Chicago.

At Miami, Mike Adams' interception set up a short field goal on the final play, and Cleveland overcame a comedy of errors.

When Browns lineman David Bowens deflected Chad Henne's third-down pass, Adams snatched the ball and ran 25 yards to the 2. On fourth down, Phil Dawson kicked a 23-yard field goal for the win.