90-minute British DnaNudge COVID-19 test is accurate, Lancet study finds

An employee working with the NHS test and trace programme staffs a COVID-19 testing centre in north London on September 16, 2020. (AFP)
Short Url
Updated 18 September 2020

90-minute British DnaNudge COVID-19 test is accurate, Lancet study finds

  • Health Secretary Matt Hancock told LBC radio that Britain was rolling out the tests across hospitals
  • Hancock said the machines could also be deployed at other locations such as schools

LONDON: A British COVID-19 test known as DnaNudge that gives results in just over an hour and which requires no laboratory was accurate in almost all cases, an academic review in the Lancet has found.
Faster testing could allow more people to return to work or permit testing on entry to hospital, thus slowing a second spike in coronavirus infections.
The new test, based on the design of a DNA test developed by a professor at Imperial College London, received approval for clinical use by the Medicines and Healthcare Products Regulatory Agency (MHRA) at the end of April after successful trials.
In a study in The Lancet Microbe, the test was found to have an average sensitivity – the ability to correctly identify those with COVID-19 – of 94.4% and a specificity – correctly identifying those without the disease – of 100%.
“These results suggest that the CovidNudge test, which can be performed at a patient’s bedside without the need to handle any sample material, has comparable accuracy to standard laboratory testing,” Professor Graham Cooke, lead author of the study from the Department of Infectious Disease at Imperial College London, said.
The Lancet paper described the test, which requires one nostril swab, as “a sensitive, specific, and rapid point of care test for the presence of SARS-CoV-2 without laboratory handling or sample pre-processing.”
Health Secretary Matt Hancock told LBC radio that Britain was rolling out the tests across hospitals.
“The critical thing in terms of usefulness is that the machine doesn’t need to be in a lab — it is about the size of a shoebox — therefore you can put one, say, in an A&E (accident and emergency) department and they can know whether people coming in have got the coronavirus or not,” Hancock said.
Hancock said the machines could also be deployed at other locations such as schools.
Each box can run one test at a time so could process about 16 tests per day, said a spokeswoman for the company that produces the tests.


Study finds AstraZeneca’s COVID-19 vaccine follows genetic instructions

Updated 22 October 2020

Study finds AstraZeneca’s COVID-19 vaccine follows genetic instructions

  • Bristol University virology expert David Matthews: The vaccine is doing everything we expected and that is only good news in our fight against the illness
  • AstraZeneca, which is developing the vaccine with Oxford University researchers, is seen as a frontrunner in the race to produce a vaccine to protect against COVID-19

LONDON: AstraZeneca’s Oxford COVID-19 vaccine accurately follows the genetic instructions programmed into it by its developers to successfully provoke a strong immune response, according to a detailed analysis carried out by independent UK scientists.
“The vaccine is doing everything we expected and that is only good news in our fight against the illness,” said David Matthews, an expert in virology from Bristol University, who led the research.
AstraZeneca, which is developing the vaccine with Oxford University researchers, is seen as a frontrunner in the race to produce a vaccine to protect against COVID-19.
The first data from late-stage large-scale clinical trials being conducted in several countries around the world, including Brazil, the United States and Britain, are expected to be released before the end of the year.
The vaccine — known either as ChAdOx1 or AZD1222 — is made by taking a common cold virus called an adenovirus from chimpanzees and deleting about 20% of the virus’s instructions. This means it is impossible for the vaccine to replicate or cause disease in humans.
The Bristol researchers’ focus was to assess how often and how accurately the vaccine is copying and using the genetic instructions programmed into it by its designers. These instructions detail how to make the spike protein from the coronavirus, SARS-CoV-2 that causes COVID-19.
Once the spike protein is made, the immune system reacts to it, training the immune system to identify a real COVID-19 infection.
“This is an important study as we are able to confirm that the genetic instructions underpinning this vaccine ... are correctly followed when they get into a human cell,” Matthews said in a statement about the work.
His team’s research was not peer reviewed by other scientists, but was published as a preprint before review.