The Lakers used a 20-0 run in the last 6 minutes of the second quarter to take a commanding lead and didn't trail after that en route to their eighth win in nine games.
Kobe Bryant, who went to the bench with 5 1/2 minutes left, came up one assist shy of a triple-double, finishing with 17 points, 10 rebounds and nine assists.
Luis Scola led Houston with 28 points and 10 rebounds.
At Oakland, Rodrigue Beaubois scored a career-high 40 points as Dallas beat Golden State to end a two-game losing streak.
Beaubois made 9 of 11 3-pointers, was 15 of 22 overall from the field and made his only free throw. The 6-foot guard from Guadeloupe had 26 points in the first half.
Shawn Marion added 18 points for Dallas. Corey Maggette led the Warriors with 21 points, and Anthony Tolliver had a career-high 21 rebounds - 20 in the second half.
At Washington, Mehmet Okur had 22 points and 11 rebounds as Utah beat Washington, extending the Wizards' team-record losing streak to 15 games.
Deron Williams had 20 points and 12 assists for the Jazz, and Carlos Boozer added 22 points - hitting all eight of his second-half shots - and 10 rebounds.
Andray Blatche led Washington with 20 points, and Nick Young had 16. The Wizards haven't won since Feb. 28.
At New Orleans, Brandon Roy scored 28 points as Portland eliminated New Orleans from playoff contention with its 10th win in 12 games.
Roy hit 11 of his first 12 shots, only two of them layups.
He finished 12 of 14 in 32 minutes. LaMarcus Aldridge added 24 points.
Darren Collison had 22 points for New Orleans on 10-of-10 shooting.
At Chicago, Jannero Pargo scored a season-high 27 points, and Taj Gibson had a career-high 22 points and added 13 rebounds for Chicago.
Terrence Williams led New Jersey with 16 points. The NBA-worst Nets were coming off consecutive victories.
