Pujols connected in the first, fifth and ninth innings for his fourth career three-homer game, and first since Sept. 3, 2006, against the Pirates. He has four homers in four games after hitting one in 28 games.
The Cardinals, who begin a three-game series against the NL Central-leading Reds on Monday, won their first series at Wrigley Field since taking two of three from the Cubs April 20-22, 2007.
Wainwright (7-3) improved to 5-0 in his last eight starts against the Cubs. He allowed one run and seven hits, struck out eight and walked two.
Matt Holliday had four hits for St. Louis and David Freese finished with three, including a two-run homer.
Geovany Soto homered in the seventh for the Cubs, who split a six-game homestand. Ryan Dempster (3-5) allowed six runs and nine hits in 6 2-3 innings.
Marlins 1 Phillies 0: At Miami, not even 24 hours after making the final out of Roy Halladay’s perfect game, Ronny Paulino drove in the only run to lift the Marlins to the victory.
Paulino’s sixth-inning single drove in Hanley Ramirez and made a winner of Anibal Sanchez (5-2), who gave up three hits and struck out seven in 6 2-3 innings. Leo Nunez pitched a perfect ninth for his 10th save in 12 tries as Florida ended a four-game losing streak.
Jamie Moyer (5-5) gave up one run and four hits in six innings, failing in a bid to join Phil Niekro and Jack Quinn as the only pitchers to win 100 games after turning 40.
Dodgers 4 Rockies 3: At Denver, Clayton Kershaw struck out nine in five innings and Xavier Paulhit a tiebreaking RBI single in the sixth to lead the Dodgers to the victory.
Kershaw (5-3) allowed two runs and four hits, but struggled at times with his control while matching his season high for strikeouts. He walked four, had a wild pitch and hit the first batter he faced.
In all, five Los Angeles pitchers notched 14 strikeouts, including one by Jonathan Broxton, who gave up an unearned run in the ninth but still earned his 13th save in 15 chances.
The win was the Dodgers’ 10th in their last 12 games against NL West opponents, and they have the best intradivision record in baseball at 15-5.
Jhoulys Chacin (3-3) gave up four runs in 5 1-3 innings for Colorado. Troy Tulowitzkiwent 2 for 3 with an RBI single.
Braves 5 Pirates 2: At Atlanta, pinch-hitter Chipper Jones had a tiebreaking RBI single in the eighth inning and Atlanta completed a three-game sweep.
Nate McLouth started the decisive rally with a one-out walk. He swiped second before Joel Hanrahan (1-1) walked pinch-hitter Brian McCann. Martin Prado struck out but Jones followed with a bloop single into shallow left field, just out of the reach of shortstop Ronny Cedeno.
Jason Heyward added a two-run triple off Javier Lopez as the Braves won their fifth straight game to pull within a half-game of NL East-leading Philadelphia.
Padres 3 Nationals 2, 11 innings: At San Diego, pinch-hitter Nick Hundley singled in Lance Zawadzki from second base with two outs in the 11th inning to give San Diego the victory.
Zawadzki started the winning rally with an infield single that deflected off pitcher Sean Burnett’s glove. Second baseman Adam Kennedy fielded it and his errant throw went into the Padres’ dugout, putting Zawadzki on second. Matt Capps relieved and Hundley singled to left. There was no throw home as the Padres took two of three.
Giants 6 Diamondbacks 5, 10 innings: At San Francisco, Andres Torres hit a two-out RBI single in the 10th inning and the Giants handed the Diamondbacks their seventh consecutive loss.
Torres hit a sharp liner to right off Carlos Rosa (0-1) for the first game-ending hit of his career and his fourth single of the game. Juan Uribescored after starting the rally with a two-out single.
Brian Wilson (1-0) pitched a 1-2-3 10th with two strikeouts for the win, the closer’s third straight outing not allowing a baserunner.
The Giants rallied in the ninth against closer Chad Qualls, getting an RBI single from Freddy Sanchez and a tying RBI groundout from Pablo Sandoval.
Arizona’s skid matches its worst of the season.
Astros 2 Reds 0, 10 innings: At Cincinnati, Lance Berkman hit a two-run double in the 10th inning and the Astros salvaged the finale of the three-game series.
Micah Owings (3-1) walked pinch-hitter Cory Sullivan and Michael Bournwith one out. Jeff Keppinger fouled out before Berkman hit Owings’ first pitch into the right-field corner.
Brandon Lyon (1-1) worked out of a bases-loaded jam in the bottom of the ninth to get the win. Orlando Cabrera flied out to right to end the threat.
Matt Lindstrom pitched the 10th for his 11th save in 12 tries for Houston, which had lost three in a row and six out of seven.
Cincinnati’s streak of consecutive games with at least one home run ended at 18, the third-longest such streak in franchise history.
Mets 10 Brewers 4: At Milwaukee, knuckleballer R.A. Dickey pitched seven innings and Angel Pagan homered to help the Mets avoid a three-game sweep.
The Mets battered Milwaukee’s shaky bullpen, which allowed eight runs in four innings, to improve to 4-12 in May away from Citi Field.
After the Mets squandered bases-loaded situations in seven previous at-bats in the series, Luis Castillo singled weakly up the middle with two outs in the sixth inning off Jeff Suppan (0-2) to give New York a 4-2 lead.
Rickie Weeks homered twice for the Brewers, who finished the homestand 4-2.
Dickey (2-0) allowed four runs and nine hits in the longest of his three starts this season.
Randy Wolf gave up two runs and five hits in five innings for the Brewers. He walked five and struck out three.
