The victory was the first for interim manager Juan Samuel, who was promoted when Dave Trembley was fired Friday. The Orioles lost Samuel's first two games by a combined 19-2 score.
Cesar Izturis led off the 11th with a walk against Hideki Okajima (2-2) and went to second on a sacrifice. After Miguel Tejada was walked intentionally, Markakis — mired in an 0-for-14 skid — blooped a single to center that easily scored the winning run.
At Toronto, Robinson Cano hit a tiebreaking, two-run single in the eighth inning as New York rallied past Toronto to avoid a three-game sweep.
Vernon Wells' two-run homer in the sixth was the only hit allowed by Yankees starter Javier Vazquez (5-5) in seven innings, and New York's power-packed lineup _ which managed just three runs in the first 30 innings of the series _ scored four times in the eighth.
The comeback spoiled a fine outing by Blue Jays right-hander Brandon Morrow, who didn't allow a run through the first seven innings. Scott Downs (1-5) took the loss.
At Arlington, Texas, John Jaso drove in five runs and Matt Garza won for the first time in a month as Tampa Bay avoided a weekend sweep to Texas.
Jaso had a two-run homer, a two-run single and an RBI double as the designated hitter from the leadoff spot, a day after the rookie became the first Rays catcher ever to bat first.
Carlos Pena also homered for Tampa Bay (37-20), which still has the best record in the majors and a two-game lead over the New York Yankees in the AL East.
At Oakland, California, Gio Gonzalez struck out four batters in seven innings to win his third straight decision as Oakland scored all of its runs with two outs against Minnesota.
Jack Cust and Kevin Kouzmanoff hit back-to-back RBI singles in the first to stake Gonzalez (6-3) to an early 2-0 lead. Ryan Sweeney hit an RBI double in the second and Mark Ellis and Cliff Pennington added RBI singles in the third to chase the Twins' Nick Blackburn (6-3).
Delmon Young hit a two-run homer off Tyson Ross in the eighth for the Twins, who were tyring for their first sweep in Oakland since July 18-20, 1997.
At Kansas City, Missouri, Brian Bannister won his career-high fifth straight start and Jose Guillen hit a three-run homer as Kansas City roughed up Jeremy Bonderman.
Bannister (6-3) improved to 20-8 in day games and is 5-2 with a 2.16 ERA in nine starts against the Tigers. He also ended his streak of allowing a home run at nine consecutive games.
At Chicago, Paul Konerko hit a two-run homer and Carlos Quentin added a go-ahead two-run single in the seventh inning to rally Chicago past Cleveland.
J.J. Putz (1-2) struck out two in a scoreless seventh to get the win, and Bobby Jenks pitched a perfect ninth for his ninth save in 10 chances.
Lou Marson hit a three-run homer and Austin Kearns had three hits for the Indians, while reliever Tony Sipp (0-2) was credited with the loss.
At Seattle, Mike Napoli had four hits, including a two-run homer that snapped a seventh-inning tie and lifted the Los Angeles Angels to over Seattle for their fifth straight victory.
Joel Pineiro (4-6) got plenty of help from Erick Aybar and Napoli, who both went 4 for 5.
After the Mariners rallied to tie it at 4 in the sixth, Napoli jumped on a high slider from Shawn Kelley (3-1), driving it over the right-field wall and the outstretched arm of Ichiro Suzuki to put Los Angeles up 6-4. Napoli also singled and scored in the ninth.
Aybar added an RBI single and Howie Kendrick hit an RBI triple to break the game open.
