Long COVID could depend on severity of early infection: Study

The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study. (Reuters/File Photo)
The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study. (Reuters/File Photo)
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Updated 18 January 2021

Long COVID could depend on severity of early infection: Study

The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study. (Reuters/File Photo)
  • ‘This finding could have major implications as to how the disease needs to be managed’

LONDON: The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study.

Researchers from Cambridge University studied 207 people who tested positive for COVID-19 over three months, finding that subjects with mild or no symptoms offered a rapid, strong immune response soon after infection.

The 207 people in the experiment ranged from asymptomatic healthcare workers to patients requiring ventilation. 

The team analyzed blood samples taken regularly over three months, and compared them with others taken from 45 healthy people.

The healthiest in the study produced anti-virus cells in larger numbers than the patients with severe COVID-19 infections. The first group also developed immunity cells within the first week of infection.

But the people with severe cases who required hospitalization were found to have an impaired immune response, which frustrated the body’s attempts to fight the virus, leading to more severe infection.

This weakened response to COVID-19 is characterized by inflammation of several organs, which starts right after a person catches the disease. 

Scientists say abnormalities in immune cells could explain the slower response to viral infection as well as the organ inflammation.

These two crucial factors could contribute to the severity of the disease and the phenomenon known as long COVID, where people feel symptoms and have health issues many months after contracting and recovering from the virus.

“Our evidence suggests that the journey to severe COVID-19 may be established immediately after infection, or at the latest around the time that they begin to show symptoms,” said Dr. Paul Lyons, a Cambridge academic and senior co-author of the study.

“This finding could have major implications as to how the disease needs to be managed, as it suggests we need to begin treatment to stop the immune system causing damage very early on, and perhaps even pre-emptively in high-risk groups screened and diagnosed before symptoms develop.”


6.3-magnitude earthquake hits central Greece

6.3-magnitude earthquake hits central Greece
Updated 36 min 52 sec ago

6.3-magnitude earthquake hits central Greece

6.3-magnitude earthquake hits central Greece

ATHENS: A strong 6.3-magnitude earthquake hit central Greece on Wednesday, the US Geological Survey said, prompting residents in the city of Larissa to rush into the streets according to local media.
The Institute of Geodynamics in Athens said the quake, which could be felt across central and northern Greece, had measured at a magnitude of 6.0.
According to the Athens observatory, the epicentre of the quake was 21 kilometres (13 miles) south of the town of Elassona, near Larissa.


Made in India: Ministers, officials prefer locally-developed vaccine over AstraZeneca

Made in India: Ministers, officials prefer locally-developed vaccine over AstraZeneca
Updated 03 March 2021

Made in India: Ministers, officials prefer locally-developed vaccine over AstraZeneca

Made in India: Ministers, officials prefer locally-developed vaccine over AstraZeneca
  • Prime Minister Narendra Modi earlier opted for an Indian-made COVID-19 vaccine

NEW DELHI: Government ministers and officials were following Prime Minister Narendra Modi lead by opting on Tuesday for an Indian-made COVID-19 vaccine approved without late-stage efficacy data, instead of the AstraZeneca one.
India’s health, foreign and law ministers, and state governors, all flocked to Twitter to express support for the much-criticized Bharat Biotech’s COVAXIN vaccine, after it was administered to Modi on Monday.
“Made-in-India vaccines are 100% safe,” Health Minister Harsh Vardhan said after being inoculated with COVAXIN.
Many state officials and doctors have refused to take COVAXIN before its effectiveness could be proved. Bharat Biotech says it has completed the late-stage trial and results will be out this month.
The company said the endorsement by Modi and other ministers would set an example for other Indians and reduce “vaccine hesitancy.” It is seeking to sell COVAXIN to countries including Brazil and the Philippines.
COVAXIN and the AstraZeneca vaccines were approved by India’s regulator in January. The government has distributed to states a total of 50 million doses of the vaccines but only 12 percent of the 12 million people immunized so far have taken COVAXIN, according to government data.


Explosion hits Dutch COVID-19 testing center, no injuries — police

Explosion hits Dutch COVID-19 testing center, no injuries — police
Updated 03 March 2021

Explosion hits Dutch COVID-19 testing center, no injuries — police

Explosion hits Dutch COVID-19 testing center, no injuries — police

AMSTERDAM: Dutch police on Wednesday said a coronavirus testing location north of Amsterdam appeared to have been intentionally targeted after an explosion went off at the location before the site opened.

The blast in the town of Bovenkarspel, 55 km north of the capital, shattered windows but caused no injuries, police from the province of North Holland said in a statement.

They said they had cordoned off the area to investigate.

The explosive “must have been placed” there, police spokesman Menno Hartenberg told Reuters, adding that “something metal” had caused the explosion.

“We don't know yet exactly what exploded, the explosives experts must first investigate,” Hartenberg said.

“What we're saying is that something like that doesn't just happen by accident, it has to be laid,” he spokesman said.


Pakistan Senate election kicks off as Imran Khan’s ruling party looks for majority

Pakistan Senate election kicks off as Imran Khan’s ruling party looks for majority
Updated 03 March 2021

Pakistan Senate election kicks off as Imran Khan’s ruling party looks for majority

Pakistan Senate election kicks off as Imran Khan’s ruling party looks for majority
  • Imran Khan’s coalition does not have a majority in the Senate, needed to pass key legislation

ISLAMABAD/KARACHI: The ruling party of Prime Minister Imran Khan and his political allies will seek to wrest control of Pakistan’s Senate from opposition parties on Wednesday in indirect elections to 37 seats in the 104-member upper house of the country’s parliament.
Though his party won the 2018 general election, Khan’s coalition does not have a majority in the Senate, needed to pass key legislation – including legal reforms sought by global institutions such as the International Monetary Fund (IMF) and money laundering watchdog the Financial Action Task Force (FATF).
“They have difficulty in legislating, and many laws are stuck,” Ahmed Bilal Mehboob, head of the independent research organization PILDAT, said.
Khan’s Pakistan Tehreek-e-Insaaf (PTI), which translates into Pakistan Movement for Justice, has 12 seats in the Senate, and the two main opposition parties Pakistan Peoples Party (PPP) and Pakistan Muslim League – Nawaz (PML-N) have 12 and 25 seats each.
PTI is looking to go up to 25 seats after the elections, and, along with other coalition parties and independents, have a slender majority in the Senate.
The electoral college for the Senate elections, which are held every three years on half of the chamber’s strength, comprises Pakistan’s four provincial assemblies and the lower house of parliament.
With opposition parties controlling the Senate, the government has had to pass interim legislation through Presidential Ordinances, which expire in 120 days.
The government’s legislators and allies in the lower house of parliament will vote on making Khan’s finance minister, Abdul Hafiz Sheikh, a senator. The result could show how much confidence there is in the administration.
“It could determine who has a majority in parliament... it will be an embarrassment for the government, and could even lead to seeking a fresh vote of confidence,” Mehboob said.
The lead up to the potentially pivotal election has been marked by the government and opposition charging each other with seeking votes through unfair means.


Daesh claims responsibility for attack on media workers in eastern Afghanistan

Daesh claims responsibility for attack on media workers in eastern Afghanistan
Updated 03 March 2021

Daesh claims responsibility for attack on media workers in eastern Afghanistan

Daesh claims responsibility for attack on media workers in eastern Afghanistan
  • Daesh fighters targeted three female employees of a television station

Daesh claimed responsibility for an attack that killed three female media workers in eastern Afghanistan on Tuesday evening.
The militant group, which has a presence in Afghanistan, said its fighters had targeted the three female employees of a television station in the eastern city of Jalalabad, according to SITE Intelligence group.
Three women who worked for Enikas TV aged between 18 and 20 had died and a fourth was critically injured after being shot on their way home from work, Afghan officials had said.