Long COVID could depend on severity of early infection: Study

The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study. (Reuters/File Photo)
The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study. (Reuters/File Photo)
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Updated 18 January 2021

Long COVID could depend on severity of early infection: Study

The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study. (Reuters/File Photo)
  • ‘This finding could have major implications as to how the disease needs to be managed’

LONDON: The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study.

Researchers from Cambridge University studied 207 people who tested positive for COVID-19 over three months, finding that subjects with mild or no symptoms offered a rapid, strong immune response soon after infection.

The 207 people in the experiment ranged from asymptomatic healthcare workers to patients requiring ventilation. 

The team analyzed blood samples taken regularly over three months, and compared them with others taken from 45 healthy people.

The healthiest in the study produced anti-virus cells in larger numbers than the patients with severe COVID-19 infections. The first group also developed immunity cells within the first week of infection.

But the people with severe cases who required hospitalization were found to have an impaired immune response, which frustrated the body’s attempts to fight the virus, leading to more severe infection.

This weakened response to COVID-19 is characterized by inflammation of several organs, which starts right after a person catches the disease. 

Scientists say abnormalities in immune cells could explain the slower response to viral infection as well as the organ inflammation.

These two crucial factors could contribute to the severity of the disease and the phenomenon known as long COVID, where people feel symptoms and have health issues many months after contracting and recovering from the virus.

“Our evidence suggests that the journey to severe COVID-19 may be established immediately after infection, or at the latest around the time that they begin to show symptoms,” said Dr. Paul Lyons, a Cambridge academic and senior co-author of the study.

“This finding could have major implications as to how the disease needs to be managed, as it suggests we need to begin treatment to stop the immune system causing damage very early on, and perhaps even pre-emptively in high-risk groups screened and diagnosed before symptoms develop.”


Myanmar’s ousted MPs form new shadow government

Myanmar’s ousted MPs form new shadow government
Updated 39 min 38 sec ago

Myanmar’s ousted MPs form new shadow government

Myanmar’s ousted MPs form new shadow government
  • Helming the so-called ‘National Unity Government’ is Aung San Suu Kyi, in her position as State Counsellor, and President Win Myint — who is also under house arrest
  • The junta has said anyone working with the CRPH is committing ‘high treason,’ and have announced arrest warrants for hundreds of prominent activists and politicians

YANGON: A “parliament” working in hiding to oust Myanmar’s junta from power announced a new shadow government Friday, with deposed leader Aung San Suu Kyi at its helm alongside ethnic minority politicians.
The country has been in turmoil since the military detained Suu Kyi and seized power, triggering a massive uprising that the junta has sought to quell with lethal force.
Besides demanding for democracy’s return, protesters are also increasingly calling for more of a governing role for the country’s minority groups — which have long seen their voices marginalized by the ethnic Bamar majority.
The Committee Representing Pyidaungsu Hluttaw (CRPH) — a group of lawmakers mostly from Suu Kyi’s party attempting to govern underground via a shadow parliament — on Friday announced its leaders.
Helming the so-called “National Unity Government” is Suu Kyi, in her position as State Counsellor, and President Win Myint — who is also under house arrest and facing a barrage of charges from the junta.
They are flanked by a vice president who is ethnic Kachin and a prime minister who is ethnic Karen, said Min Ko Naing, a prominent democracy leader, in an address on the CRPH’s official Facebook page.
“We have organized a government which has the largest number of ethnic minority groups,” he said.
A list of appointed ministers also included prominent leaders from the Chin, Shanni, Mon, Karenni and Ta’ang ethnic groups.
The politicians were chosen based on results from the 2020 election, input from a nationwide anti-coup protest movement, and ethnic minority groups — including armed rebels in the country’s border territories, said Min Ko Naing.
“We have to pull it from the root... we must try to eradicate it,” he said, as he raised the three-finger salute — the symbol of resistance
“Only the people can decide the future.”
The junta has said anyone working with the CRPH is committing “high treason,” and have announced arrest warrants for hundreds of prominent activists and politicians — some of whom now hold positions in the new “National Unity Government.”
Myanmar has more than 130 official ethnic minority groups.
But the country’s political fate has long been tightly held by the Bamar majority — first under a nearly five-decade junta regime which forced a so-called “Bamarization” on minorities; and then under Suu Kyi’s administration.
Since the coup, more than 720 people have been killed in anti-coup unrest, according to the local monitoring group.


Pakistan appoints new finance minister in latest cabinet shake-up

Pakistan appoints new finance minister in latest cabinet shake-up
Updated 11 min 37 sec ago

Pakistan appoints new finance minister in latest cabinet shake-up

Pakistan appoints new finance minister in latest cabinet shake-up
  • Hammad Azhar, who was made finance minister less than a month ago, has now been replaced by Shaukat Tarin
  • Pakistan is currently working on national budget and on implementing economic reforms suggested by the IMF

ISLAMABAD: Pakistan's Prime Minister Imran Khan appointed a new finance minister on Friday, replacing Hammad Azhar, who received the portfolio less than a month ago.

Shaukat Tarin, the new appointee, is a banker who also served at the same position from 2009 to 2010 under the Pakistan Peoples Party administration of former prime minister Yousaf Raza Gilani.

The news was announced by the newly appointed information minister Chaudhry Fawad Hussain who shared the notification of the recent cabinet reshuffle in a Twitter post:

“Prime Minister Imran Khan has made changes in the cabinet, the details of these changes are attached.”

 

 

Azhar will now look after the Energy Ministry. He was given the additional portfolio of finance and revenue after Abdul Hafeez Shaikh was recently asked to step down last month over what the government described as rising inflation.

The change to the finance ministry comes at a time when the government is working on the annual budget which is likely to be presented in June. Pakistan's economic managers are also implementing structural reforms suggested by the International Monetary Fund to the country's economy.

Apart from the two cabinet changes, the prime minister also took the Economic Affairs Ministry from Makhdoom Khusro Bukhtiar and gave him the Ministry of Industries and Production.

Omar Ayub, who was previously supervising the Power and Petroleum Divisions, has now been tasked to take care of the Economic Affairs Ministry.

Senator Shibli Faraz has also been assigned the Ministry of Science and Technology which fell vacant when Chaudhry Fawad Hussain was appointed as federal minister for information and broadcasting.

“As info minister my task is to change misperceptions about Pak[istan] and highlight the vibrant effort of the Government,” Hussain wrote on Twitter.

 

 


Hong Kong media tycoon Jimmy Lai jailed for 12 months over huge democracy rally

Hong Kong media tycoon Jimmy Lai jailed for 12 months over huge democracy rally
Updated 16 April 2021

Hong Kong media tycoon Jimmy Lai jailed for 12 months over huge democracy rally

Hong Kong media tycoon Jimmy Lai jailed for 12 months over huge democracy rally
  • Jimmy Lai currently in custody after his arrest under Beijing’s sweeping national security law

HONG KONG: Hong Kong media tycoon Jimmy Lai was jailed for 12 months on Friday over one of the city’s biggest ever protests in 2019.
It is the first time the 73-year-old – who is currently in custody after his arrest under Beijing’s sweeping national security law – has received a sentence for his activism.


Police: 8 dead in shooting at FedEx facility in Indianapolis

Police: 8 dead in shooting at FedEx facility in Indianapolis
Updated 16 April 2021

Police: 8 dead in shooting at FedEx facility in Indianapolis

Police: 8 dead in shooting at FedEx facility in Indianapolis
  • The shooter wasn’t immediately identified
  • At least four were hospitalized, including one person with critical injures
INDIANAPOLIS: Eight people were shot and killed in a late-night shooting at a FedEx facility in Indianapolis, and the shooter has killed himself, police said.
Multiple other people were injured Thursday night when gunfire erupted at the facility near the Indianapolis International Airport, police spokesperson Genae Cook said.
At least four were hospitalized, including one person with critical injures. Another two people were treated and released at the scene, Cook said.
The shooter wasn’t immediately identified, and Cook said investigators were still in the process of conducting interviews and gathering information.
Police were called to reports of gunfire just after 11 p.m. and officers observed an active shooting scene, Cook said. The gunman later killed himself.
FedEx released a statement saying it is cooperating with authorities and working to get more information.
“We are aware of the tragic shooting at our FedEx Ground facility near the Indianapolis airport. Safety is our top priority, and our thoughts are with all those who are affected,” the statement said.
Family members gathered at a local hotel to await word on loved ones. Some said employees aren’t allowed to have their phones with them while working shifts at the facility, making it difficult to contact them, WTHR-TV reported.
Live video from news outlets at the scene showed crime scene tape in the parking lot outside the facility.
A witness who said he works at the facility told WISH-TV that he saw a man with a gun after hearing several gunshots.
“I saw a man with a submachine gun of some sort, an automatic rifle, and he was firing in the open,” Jeremiah Miller said.
Another man told WTTV that his niece was sitting in her car in the driver’s seat when the gunfire erupted, and she was wounded.
“She got shot on her left arm,” said Parminder Singh. “She’s fine, she’s in the hospital now.”
He said his niece did not know the shooter.

Opponents of Myanmar military rule hold ‘silent strike’

Opponents of Myanmar military rule hold ‘silent strike’
Updated 16 April 2021

Opponents of Myanmar military rule hold ‘silent strike’

Opponents of Myanmar military rule hold ‘silent strike’
  • Many Myanmar citizens have been taking to the streets day after day
  • The military has also been rounding up its critics and has published the names of more than 200 wanted people

Opponents of military rule in Myanmar observed a “silent strike” on Friday, with many people staying home to mourn the more than 700 people killed in protests against a Feb. 1 coup and others wearing black held small marches in several cities and towns.
Many Myanmar citizens, infuriated by the return of military rule after five years of civilian government led by democracy champion Aung San Suu Kyi, have been taking to the streets day after day with activists thinking up new ways to show opposition as the security forces step up their suppression.
“Let’s make the roads silent,” protest leader Ei Thinzar Maung posted on her Facebook page.
“We have to stage a Silent Strike to show our sorrow for the martyrs who have scarified their lives. The most silent voice is the loudest.”
Friday is the fourth day of the five-day traditional Buddhist New Year holiday, known as Thingyan. Most people this year are shunning the usual festivities to focus on their campaign against the generals who overthrew Suu Kyi’s government and locked up her and many others.
Streets in the main city of Yangon were largely deserted, residents said, while black-clad protesters held small rallies in half a dozen cities and towns, media reported.
There were no immediate reports of violence but overnight, two people were shot and killed in the central town of Myingyan, Radio Free Asia reported.
A spokesman for the junta could not be reached for comment.
The military has also been rounding up its critics and has published the names of more than 200 people wanted under a law that makes it illegal to encourage mutiny or dereliction of duty in the armed forces.
Two prominent protest organizers were arrested on Thursday along with an actor and singer, both known for speaking out against the coup.
Late on Thursday, soldiers raided a famous Buddhist monastery in the second city of Mandalay and arrested two people, the Myanmar Now media group reported.
Opponents have been organizing both at home and abroad with the aim of stepping up their campaign.
A previously unknown group called the Ayeyarwaddy Federal Army said on Facebook it aimed to fight the military to restore an elected government and protect the people and it called for volunteers.
It gave no details about how it aimed to take on the well-equipped and seasoned army, which has been battling ethnic minority insurgents for decades.
International pressure has also been slowly building on the military, particularly from Western governments, though the military has a long record of brushing off outside pressure.
The European Union has agreed to impose sanctions on another 10 individuals linked to the coup and to target two businesses run by the armed forces for the first time in protest at the military takeover, two diplomats said.
While the EU has an arms embargo on Myanmar and targeted 11 senior military officials last month, the decision to target the two companies is the most significant response for the bloc since the coup.
EU diplomats said in March that parts of the military’s conglomerates, Myanmar Economic Holdings Limited and Myanmar Economic Corporation would be targeted, barring EU investors and banks from doing business with them.
Human rights groups have also called for them to be sanctioned.
The EU declined to comment and no one at Myanmar’s mission to the EU in Brussels could be reached for reaction.