"The surgical operation went well. The patient is conscious," said Annette Tuffs, a spokeswoman for the Heidelberg University Hospital in southwest Germany that carried out the surgery.
The operation was carried out by several surgeons, she said.
Mubarak, 81, who was on a visit to Germany on Thursday to meet Chancellor Angela Merkel when he suffered gall bladder pains, underwent a "successful operation," a presenter on Egypt's state television said earlier.
"He is in intensive care after waking up and talking to members of his family and doctors," she said.
The president was conscious following the surgery and was speaking with family members in the intensive care unit, MENA said.
The veteran president, accompanied by wife Suzanne and other family members, delegated executive powers to Prime Minister Ahmed Nazif until he returns to Cairo, state media announced early on Saturday ahead of the operation.
MENA said Mubarak, who has been president for almost three decades, underwent tests on Friday that confirmed "chronic infections in the gall bladder."
Gall bladder removal is a benign operation. The most common treatment, laparascopic cholecystectomy, is performed under anesthesia and involves the insertion of a tiny camera through several tiny incisions in the torso.
This method allows a faster recovery, and the patient can leave hospital in 48 to 72 hours.
Mubarak had been active in the months before his latest visit to Germany, giving speeches and touring provinces, although last year he canceled a scheduled trip to Washington and limited public appearances after the death of his 12-year-old grandson.
Mubarak's term in office ends next year and concern about his health often prompts speculation about the leadership of the Arab world's most populous nation, a US ally that plays a critical role in issues ranging from Middle East peace efforts to curbing religious extremism.
Fathi Sorour, speaker of Parliament, which is dominated by Mubarak's National Democratic Party, sent a telegram on behalf of Parliament wishing a "speedy recovery" to the president. Sorour said millions of Egyptians will pray for Mubarak to return home "safe and sound."
Mohammed El-Baltagi, an MP representing the Muslim Brotherhood opposition movement, said his group "hopes for a speedy recovery for the president and his safe return to the country."
