Cleveland has won four in a row and lost only one of its last 11 games, improving to an NBA-best 53-15 win-loss record.
Richard Hamilton had 24 points and was one of six Pistons who scored in double figures.
Detroit has lost three straight games and eight of 10.
At Miami, Manu Ginobili scored 22 points, George Hill had 16 and surging San Antonio wasted most of a 25-point, third-quarter lead before beating Miami.
Richard Jefferson added 15 points and Tim Duncan had 12 points and 11 rebounds for the Spurs, who've won eight of their last nine and ensured they would end the night no worse than No. 7 in the Western Conference standings.
Dwyane Wade scored 28 points for Miami, which lost for the first time in its last seven home games. Jermaine O'Neal added 13 points and Udonis Haslem finished with 10 points and 12 rebounds for the Heat, who missed a chance to move past Charlotte for the No. 6 spot in the East race.
Charlotte lost at Indiana.
At Sacramento, Kobe Bryant scored 30 points and Pau Gasol added 28 points and 11 rebounds as the Los Angeles Lakers completed a sweep of their Northern California swing with a 106-99 victory over the Kings.
After committing 24 turnovers and barely holding on for a 124-121 victory at Golden State on Monday night, the Lakers were much sharper on the back end of their trip. They committed just two turnovers in the first half and 10 for the game, overpowering the Kings inside to win their fourth straight following a season-high, three-game losing streak.
Andrew Bynum added 21 points and 12 rebounds, and the Lakers finished with 60 points in the paint to remain four games ahead of Denver for the best record in the Western Conference.
At Phoenix, Jason Richardson scored 27 points and Amare Stoudemire scored 25, then sat with the rest of the Phoenix starters while the Suns' reserves finished off a 152-114 rout of Minnesota in the highest-scoring game by an NBA team this season.
Lou Amundson matched his career high with 20 points as Phoenix sent the Timberwolves to their 10th straight loss and 16th in the last 17 games.
The Suns, with eight players in double figures, shot 56 percent and won their ninth in 12 games.
At Indianapolis, Danny Granger scored 26 points to help Indiana deny Charlotte what would have been a franchise-record seventh consecutive victory.
Troy Murphy had 16 points and 13 rebounds, and Mike Dunleavy added 15 points for Indiana, which had lost 14 of its previous 17 games.
Former Pacer Stephen Graham scored a career-high 19 points and tied a career best with eight rebounds in place of All-Star forward Gerald Wallace, who missed his second straight with an injured left ankle. Stephen Jackson, another former Pacer, finished with 20 points, nine rebounds and six assists.
At East Rutherford, Jamal Crawford hit a 30-footer at the buzzer to cap his game-breaking, 15-point second quarter as Atlanta ran away from woeful New Jersey.
Crawford, the NBA scoring leader among players who have not started a game, finished with 25 points in leading Atlanta to its third straight win and ninth in 12 games.
Marvin Williams added 15 points for the Hawks, who were playing without Joe Johnson for the first time this season.
The All-Star guard has Achilles' tendinitis and did not accompany the team for its two-game road trip. Al Horford finished with 15 points and 11 rebounds.
Brook Lopez had 21 points for the Nets, who lost for the 60th time in 67 games. New Jersey needs to win three times in its last 15 games to avoid tying or breaking the NBA mark for fewest wins (9) in a season, set by the 1972-73 Philadelphia 76ers.
At Memphis, O.J. Mayo scored 24 points as Memphis sent undermanned Chicago to its eighth straight loss.
Mike Conley finished with 19 points and 10 assists, while Zach Randolph added 18 points and 12 rebounds. Rudy Gay had 12 points, and Marcus Williams and Hasheem Thabeet finished with 10 apiece.
Flip Murray scored 25 points for the Bulls, who were missing their top four scorers. Hakim Warrick came off the bench for 22, including 10 in the fourth as the Bulls made a run. Acie Law finished with a season-high 18 points, while Jannero Pargo had 12.
At Denver, J.R. Smith scored 13 of his 17 points in the fourth quarter, helping Denver pull away to the Nuggets beat Washington.
Carmelo Anthony led Denver with 29 points and 12 rebounds.
Nene added 16 points for Denver, which sent Washington to its ninth consecutive loss.
The game marked the return of Nuggets coach George Karl, who was back on the bench after missing four games over the past week for cancer treatments.
Andray Blatche led the Wizards with 23 points and Al Thornton had 16.
