The seventh coach in NBA history with 1,000 wins, Karl also notched his 900th in Toronto, a 114-107 victory on Dec. 31, 2008.
Chauncey Billups scored 21 points and Gary Forbes had 15 in place of injured Carmelo Anthony as the Nuggets snapped a two-game skid.
Ex-Nugget Linas Kleiza set season highs with 26 points and 12 rebounds, but Toronto lost its fourth straight. Andrea Bargnani scored 24.
At Oakland, California, Dwyane Wade had 34 points, nine rebounds and seven assists, and LeBron James added 25 points, nine assists and seven rebounds as Miami won its season-best seventh straight game with a victory over slumping Golden State.
Miami also established a franchise best with seven consecutive wins by double digits. The Heat moved into first place in the Southeast Division for the first time all season.
Monta Ellis had 20 points and seven assists in Golden State's season-worst sixth straight loss.
Chris Bosh added 16 points and seven rebounds in the Heat's fifth consecutive win over Golden State, mired in a 1-11 stretch. The Warriors dropped their fifth straight at Oracle Arena after beginning the season 5-0 at home. They haven't won on their own floor since Nov. 15 against Detroit.
At Washington, Amare Stoudemire had 36 points and 10 rebounds to help overcome his 11 turnovers as New York beat Washington for its seventh straight victory.
Stoudemire posted his seventh straight 30-point game.
Willie Naulls is the only other player in franchise history with such a run - and he accomplished it way back in 1962.
Gilbert Arenas scored 20 points to lead the Wizards.
At Chicago, Derrick Rose had 29 points and nine assists as Chicago held off a late rally by the Los Angeles Lakers to match a season best with its fourth straight victory.
The Bulls hit eight 3-pointers, three by Rose, who made the shot a key part of his game during the offseason.
Reserve swingman Kyle Korver connected on a trio of 3s and scored 13 points for Chicago, which held a 26-13 edge in bench points.
The 84 points marked a season low for the Lakers. The two-time defending NBA champions were led by Kobe Bryant's 23 points, though he shot just 9 for 23 from the floor.
It was the Bulls' first win over the Lakers in nearly four years.
At Indianapolis, Danny Granger scored 18 points to help Indiana beat Charlotte.
Brandon Rush added 16 points and Mike Dunleavy 15. Roy Hibbert had 13 points, 14 rebounds, six assists and three blocks for the Pacers.
Gerald Wallace led the Bobcats with 26 points. Ex-Pacer Stephen Jackson had 15 points and eight assists, but he shot 7 for 17 from the field and committed seven turnovers.
At Minneapolis, Kevin Love had 27 points and 18 rebounds, and Darko Milicic blocked a career-high seven shots against the team that drafted him No. 2 overall in 2003, leading Minnesota over Detroit.
Luke Ridnour had 20 points and 10 assists, scoring 11 in the fourth quarter to help the Timberwolves to just their sixth win of the season.
Richard Hamilton scored 26 points and rookie Greg Monroe grabbed 15 rebounds in his first career start for the Pistons, who fell to 2-12 on the road.
Love had his NBA-leading 18th double-double and grabbed at least 15 boards for the ninth straight game, the longest streak since Ben Wallace did it in 14 consecutive games in 2002-03.
At New Orleans, Russell Westbrook had 29 points and 10 assists, and Kevin Durant scored 25 points as Oklahoma City beat New Orleans.
Westbrook scored 16 points in the second half, including an 18-foot jumper as he was fouled by Chris Paul to give the Thunder a 93-87 lead with 1:41 to go.
Serge Ibaka had 18 points and nine rebounds, and Jeff Green added 13 points for Oklahoma City.
David West had 24 points, 13 rebounds and four steals for the Hornets, but scored only six in the second half. Paul had 18 points and five steals, and Marco Belinelli scored 15, but missed a 3-point attempt that could have tied it with a little more than 10 seconds left.
At Milwaukee, Andrew Bogut had 24 points, 22 rebounds and five blocked shots to lead Milwaukee over Houston.
It was Bogut's fourth 20-20 performance of his career and his best rebounding effort since dislocating his right elbow, breaking his hand and wrist in an eye averting fall last April.
At San Antonio, Richard Jefferson and Manu Ginobili scored 18 points each as San Antonio won its fourth straight to keep the NBA's best record, beating Atlanta.
Tony Parker added 17 points for the Spurs. DeJuan Blair had 16 points and 12 rebounds.
Jamal Crawford led the Hawks with 23 points.
At Phoenix, Marcus Camby had 16 points and 18 rebounds, and Brandon Roy added 26 points as Portland beat Phoenix for its fourth straight win.
LaMarcus Aldridge had 23 points and Wesley Matthews scored 14 of his 16 in the first half for Portland.
Steve Nash had 24 points for the Suns and Grant Hill added 17.
At Salt Lake City, Deron Williams had a season-high 32 points as Utah beat Orlando, scoring the most points that the slumping Magic have allowed all season.
CJ Miles scored 19 of his season-high 26 in the fourth quarter for the Jazz, who swept the Magic this season. Paul Millsap had 22 points and Andrei Kirilenko added 17 to help the Jazz complete a 4-2 homestand.
Jameer Nelson scored 19, Brandon Bass had 18 and Vince Carter 17 points in the Magic's season-high fourth straight loss.
