Tim Duncan had 16 points and 13 rebounds, while Antonio McDyess added 11 points and 11 rebounds for the Spurs, who fell short in their goal of becoming the sixth team in NBA history to begin 45-8 or better.
In Orlando, Willie Green scored 24 points to lead New Orleans over Orlando.
David West added 17 points and 17 rebounds as the Hornets snapped a four-game losing streak.
The Magic erased a nine-point halftime deficit, but came up short due to a slew of late turnovers. They had 16 for the game.
Dwight Howard led the way for Orlando with 20 points and 17 rebounds.
In New York, Kobe Bryant scored 33 points in another effortless night at Madison Square Garden as Los Angeles cruised past struggling New York.
Bryant scored 19 in the first quarter and grabbed 10 rebounds for the night despite playing only 29 minutes.
Bryant shot 12 of 17 from the field and hit four 3-pointers as the Lakers made 54 percent of their shots.
In Auburn Hills, Michigan, streaking Miami beat Detroit to take over sole possession of the Eastern Conference lead.
Dwyane Wade scored 24 points and LeBron James added 16 points and 10 assists for Miami, which has won eight straight games. The Heat entered the game tied atop the conference with Boston, which had a night off Friday. The Celtics host the Heat on Sunday.
Austin Daye scored 18 points for Detroit.
In Memphis, Mike Conley had 23 points, including a key 3-pointer with 1:12 left, and eight assists as Memphis beat Milwaukee.
Sam Young finished with 19 points and a career-high eight rebounds as Memphis gave coach Lionel Hollins his 100th victory.
Corey Maggette led the Bucks with 22 points, including 20 in the third quarter to help Milwaukee erase a first-half deficit.
In Toronto, LaMarcus Aldridge scored 14 of his 37 points in the fourth quarter to lead Portland over skidding Toronto.
Coming off a career-high 42 points in Monday's win over Chicago, Aldridge shot 14 for 25 and grabbed 10 rebounds.
He went 9 for 12 from the free throw line.
Portland's Rudy Fernandez had 23, making his first eight shot attempts, six of them 3-pointers, before missing for the first time late in the third quarter.
Andrea Bargnani scored 29 points for the Raptors, who lost for the 16th time in 17 games.
In Charlotte, New Jersey ended a 12-game road losing streak by defeating Charlotte.
Brook Lopez had 31 points and 11 rebounds for his second double double of the season. Devin Harris added 16 points and eight assists for the Nets, who raced to a 12-2 lead and never trailed.
Stephen Jackson scored 21 points for the Bobcats.
In Indianapolis, Dahntay Jones scored all of his 19 points in the fourth quarter to spark Indiana's big finish against Minnesota.
Jones, who played sparingly under former coach Jim O'Brien, keyed the victory by making six of seven shots from the field — including 2 of 2 from 3-point range — as Indiana rallied from a seven-point deficit to start the fourth quarter.
Danny Granger also had 19 points for the Pacers, who won for the sixth time in seven games under interim coach Frank Vogel.
Kevin Love finished with 22 points to lead Minnesota.
In Cleveland, the hosts needed overtime to do it, but finally broke their record losing streak by edging Los Angeles.
Nearly two months after it started, Cleveland stopped the NBA-record losing streak at 26 games.
Antawn Jamison scored 35 points and made the game's biggest basket, a 3-pointer with 22 seconds left in OT for the Cavs. Daniel Gibson scored 10 in overtime.
Blake Griffin had 32 points and 13 rebounds for the Clippers.
