In the first meeting between these NBA heavyweights, the Spurs (51-11) improved the league's best record and kept the Heat in a tailspin.
Parker had 15 points and eight assists. He returned less than a week after the Spurs feared their point guard might miss up to a month with a strained calf.
LeBron James scored 26 points and Dwyane Wade had 19. It won't get much easier for the Heat, who returns home to play Chicago on Sunday.
At Orlando, Florida, Derrick Rose had 24 points and Luol Deng added 16 to help Chicago hang on for a win over Orlando in a matchup of two of the top teams in the Eastern Conference.
Dwight Howard led Orlando with 20 points and 10 rebounds, but also picked up his 16th technical foul of the season.
He faces a one-game suspension Monday against Portland if the foul is not rescinded by the NBA. Jason Richardson and Brandon Bass each chipped in 16 points.
At New York, Baron Davis scored 18 points in his Cavaliers debut, leading a stunning rally in the fourth quarter as Cleveland beat the New York Knicks for the 11th straight time.
J.J. Hickson scored 23 and Luke Harangody also had 18, but the spark came from Davis in his first game since his trade from the Los Angeles Clippers last week. He scored 12 points in the final 6-plus minutes after the Knicks had built a 12-point lead, including a 3-pointer that gave Cleveland a 116-112 lead with 10.6 seconds left.
Amare Stoudemire matched a season high with 41 points and Carmelo Anthony added 29, but the Knicks still haven't defeated the Cavs since Dec. 19, 2007.
At Boston, Ray Allen scored 27 points and pulled down a crucial offensive rebound with 12 seconds remaining to help Boston hold off Monta Ellis and Golden State.
Paul Pierce also scored 27 for the Celtics, who let an 18-point lead slip to just one late in the fourth quarter and struggled to put away the pesky Warriors.
Ellis scored 28 of his 41 points in the second half as Golden State rallied and gave the short-handed Celtics a scare right to the end.
Jeff Green added 21 points and Rajon Rondo had 16 assists for Boston.
David Lee had 26 points and 12 rebounds for the Warriors.
At Atlanta, Kevin Durant scored 29 points despite a sore ankle and Russell Westbrook hit a clinching 3-pointer to lead Oklahoma City over Atlanta.
Durant sprained his left ankle two nights earlier and wasn't cleared to play until an hour before the game, but the NBA's leading scorer turned in his usual performance.
He came in averaging 28.4 points a game. Westbrook finished with 28 points.
Joe Johnson led the Hawks with 24 and Kirk Hinrich added 21.
At London, Brook Lopez scored 25 points and New Jersey ended a six-game losing streak by beating Toronto in the first regular-season NBA game played in Europe.
Deron Williams added 16 points and 11 assists at the O2 Arena despite playing with injuries to both hands - a strained right wrist and bruised left hand. It was the All-Star guard's first win with the Nets since being acquired from Utah last week.
DeMar DeRozan led Toronto with 30 points and Andrea Bargnani added 23.
Attendance was an announced sellout of 18,689, but there were some empty seats. The teams will face each other again at the O2 on Saturday, as the NBA decided to bring regular-season games to Europe for the first time as part of its push to increase its fan base on the continent. The O2 has hosted preseason games for the last four years.
At Philadelphia, Andre Iguodala had 22 points, 13 assists and 10 rebounds for his second triple-double of the season as Philadelphia overcame another stellar effort from Kevin Love to beat Minnesota.
Elton Brand scored 21 points and Thaddeus Young added 16 for the Sixers, who climbed back above .500 at 31-30. They currently hold the seventh spot in the Eastern Conference playoff race.
The Timberwolves got 21 points and 23 rebounds from Love, the 10th time he's had a 20-20 game this season. Love leads the league with 58 double-doubles.
At Memphis, Tennessee, Chris Paul broke out of a scoring slump with 23 points and 14 assists as Willie Green keyed New Orleans' fourth-quarter rally against Memphis.
Green scored 13 of his 15 points in the fourth quarter, Jarrett Jack had 19 points, and while Marco Belinelli and Carl Landry scored 14 apiece.
Zach Randolph led the Grizzlies with 20 points and 11 rebounds.
At Los Angeles, Kobe Bryant scored 27 points as the Los Angeles Lakers downed Charlotte.
Pau Gasol had 20 points and 10 rebounds, and Derek Fisher sprained his left elbow as the Lakers grinded out a shockingly rare victory over the NBA's youngest franchise.
The two-time defending champions had lost eight of their previous 10 meetings with Charlotte, the only team other than Boston with a winning record against the Lakers (8-6).
D.J. Augustin scored 22 points for the Bobcats.
At Milwaukee, Channing Frye scored 20 points as Phoenix used a 19-0 run in the third quarter to switch a deficit into a big lead against Milwaukee.
The Suns are chasing Memphis for the final playoff spot in the Western Conference and are just a half-game back after winning 12 of their last 16.
Corey Maggette scored 21 points for the Bucks, who were missing four regulars due to injuries or illness, including center Andrew Bogut.
At Dallas, Dirk Nowitzki scored 29 points and Jason Terry added 21 as Dallas pulled away from Indiana in the final 3 minutes to stretch its winning streak to eight games.
Jason Kidd's 15 points and Rodrigue Beaubois' 13 helped the Mavericks to their 18th victory in 19 games.
Danny Granger had 22 points and Darren Collison 17 for the Pacers.
