Pinch-hitter Ryan Howard also went deep, hitting a tying solo shot off Chad Qualls that ignited a five-run seventh. Michael Stutes (5-1) allowed one run in 1 1-3 innings in relief of Kyle Kendrick, and Ryan Madson finished for his 17th save in 18 chances.
Cameron Maybin and Chase Headley hit homers for the Padres, who haven’t beaten the Phillies since last June 7. They were swept by Philadelphia in a four-game series in San Diego in April.
At Cincinnati, Edgar Renteria replaced injured rookie shortstop Zack Cozart and drove in three runs to rally Cincinnati to a victory over Atlanta.
Cozart hyperextended his left elbow while trying to make a tag in the fourth inning, getting Renteria off the bench. His two-run double off Derek Lowe (6-8) started a three-run rally in the sixth inning that put the Reds ahead.
Brandon Phillips had a pair of run-scoring doubles, and Todd Frazier doubled with the bases loaded as Cincinnati pulled away.
At Chicago, Randy Wells pitched six strong innings to earn his first win since April 4, and Geovany Soto added a solo shot and an RBI single in the eighth to lead Chicago to a victory over the major league-worst Houston.
Marlon Byrd also homered for the Cubs, who will try to win three in a row on Sunday for the first time this season.
The Astros have lost 14 of its last 18 road games and six straight overall.
Wells (2-3) allowed one run on five hits. He struck out four and pitched around two walks.
