Syracuse (30-1, 17-1) matched the Big East record for victories - Connecticut also won 17 conference games in 1995-96 - and the Orange also finished the regular season with 30 wins for the first time in coach Jim Boeheim's 36-year tenure.
The Orange capped only their second unbeaten season in the Carrier Dome, going 19-0. The only other Syracuse team to go undefeated in the dome was the national championship squad of 2002-03 led by Carmelo Anthony, which finished 17-0.
Dion Waiters had 13 points for Syracuse, which held the Cardinals to 2-of-23 shooting from 3-point range and a season low in points.
Chane Behanan and Russ Smith led Louisville (22-9, 10-8) with 10 points apiece, while Gorgui Dieng finished with six on 3-of-13 shooting.
In Lawrence, Thomas Robinson had 25 points and 14 rebounds in his likely Allen Fieldhouse finale, and Tyshawn Taylor added 22 points as Kansas rolled past Texas.
Robinson scored 18 of his points in the second half as the Big 12 champion Jayhawks (26-5, 16-2) tuned up for the conference tournament in style. Kansas has won eight straight overall, 22 in a row at home and improved to 20-7 all-time against the Longhorns.
J'Covan Brown scored 29 of his 33 points in the second half for Texas (19-12, 9-9), which missed out on a chance to help its own NCAA tournament resume. The Longhorns head to Kansas City needing a couple wins to feel comfy on Selection Sunday.
In Durham, Kendall Marshall had 20 points and 10 assists, and North Carolina beat Duke to win the Atlantic Coast Conference regular-season title.
Tyler Zeller had 19 points and 10 rebounds, and Harrison Barnes added 16 points for the Tar Heels (27-4, 14-2).
UNC shot 54.5 percent and sent Duke to its deepest halftime deficit at Cameron Indoor Stadium - 24 points - while winning its seventh straight since a loss to the Blue Devils.
Mason Plumlee had 17 points, and brother Miles Plumlee added 16 points and 11 rebounds for the Blue Devils (26-5, 13-3).
In Lubbock, Texas, Kim English scored 20 points, Marcus Denman added 17 and Missouri hit a season-best 16 3-pointers to beat Texas Tech.
Denmon scored all his points in the second half, going 5 of 8 from 3-point range in the half, and Ricardo Ratliffe finished with 13 points and a career-high 15 rebounds.
The Tigers (27-4, 14-3 Big 12) slowly pulled away in the second half with 12 of their 3s coming after halftime. The win gave Missouri a school record for wins in the regular season.
Jaye Crockett scored 17 points and Ty Nurse added 12 for the Red Raiders (8-22, 1-17), who walked away with their worst finish in Big 12 play.
In Milwaukee, Jae Crowder had 26 points and 14 rebounds in his final home game, helping Marquette beat Georgetown and clinch the No. 2 seed in the Big East tournament.
Fellow senior Darius Johnson-Odom added 17 points for the Golden Eagles (25-6, 14-4). Marquette was 33 of 45 from the free throw line.
Otto Porter and Hollis Thompson scored 19 points each for the Hoyas (22-7, 12-6), who could have clinched a double-bye in the conference tournament with a victory. Marquette already had clinched the double-bye.
The Golden Eagles forced 15 turnovers, scoring 24 points off the miscues.
In Ames, Iowa, Scott Christopherson had 23 points in his final home game and Iowa State rallied to beat Baylor for its second win over a top-10 opponent this season.
Melvin Ejim added 15 points for the Cyclones (22-9, 12-6 Big 12), who also secured the No. 3 seed for next week's conference tournament.
Baylor led by as much as nine late in the second half, but the Bears went nearly 5 minutes without a point down the stretch.
Pierre Jackson had a career night with 35 points for the Bears (25-6, 12-6), who fell to the fourth seed for the Big 12 tournament.
In Nashville, Jewuan Long drove the baseline for a layup with 4.4 seconds left, and Murray State rallied from seven points down in the final 5:28 to beat Tennessee State for the Ohio Valley Conference tournament title and an automatic NCAA tournament berth.
Isaiah Canaan stripped Tigers guard Patrick Miller of the ball driving to the basket, and Long guarded Robert Covington on his 3-point attempt at the buzzer to preserve the win, getting the Racers to 30-1 and avoiding a second loss to the only team to beat them this season.
Covington led Tennessee State (20-12) with 14 points and Kellen Thornton had 11.
The Racers are back in the NCAA tournament for the first time since 2010.
In St. Louis, Tyler Brown scored 25 points, including two free throws with 6.4 seconds left, and Illinois State advanced to the final of the Missouri Valley Conference tournament.
Jackie Carmichael added 12 points and 11 rebounds for the fourth-seeded Redbirds (20-12), who rallied from 13 points down early in the second half. Illinois State snapped a 24-game slide against ranked teams dating to 1987. The Redbirds head into the tournament championship game on Sunday against No. 25 Creighton seeking their first NCAA tournament berth since 1998.
Joe Ragland had 17 points for Wichita State (27-5), which had won nine in a row and 17 of 18. Now they must wait to learn if they will receive an at-large bid to the NCAAs.
