Fielder signed a $214 million, nine-year deal with Detroit in the offseason, forming a powerful middle of the order with Cabrera that was on full display against Red Sox starter Josh Beckett (0-1). Cabrera opened the scoring in the first inning with a two-run shot to left-center, and Fielder added a solo homer in the fourth to the same part of the ballpark.
Cabrera and Fielder hit back-to-back solo homers in the fifth.
Duane Below (1-0) got the win in relief after Detroit starter Doug Fister left in the fourth with a strain in his left side.
Beckett (0-1) allowed seven runs and seven hits in 4 2-3 innings, and the five homers he gave up equaled a career high.
In Anaheim, California, Luke Hochevar took a shutout into the seventh inning and Kansas City got solo homers from Eric Hosmer and Mike Moustakas against Dan Haren in a victory over the Angels.
Albert Pujols got his first hit with Los Angeles, a double in the fourth.
Hochevar (1-0) was charged with two runs and five hits over 6 1-3 innings in his season debut.
Haren (0-1) gave up five runs and 11 hits over 5 1-3 innings and struck out five.
In Cleveland, Rajai Davis hit a two-run double in the 12th inning, Toronto rallied for the second straight game against Cleveland’s bullpen and the Blue Jays beat the Indians in extra innings again.
Davis’ hit off Tony Sipp (0-1) gave the Blue Jays a 5-3 lead and they held on to win another extra-inning game between the teams, who set a major league record by playing the longest opening-day game in history — a 16-inning marathon Thursday.
Kelly Johnson homered for the Blue Jays and Toronto starter Brandon Morrow allowed one hit in seven innings.
In Arlington, Texas, Alex Rios led off the ninth inning with a home run and the Chicago White Sox got their first win for new manager Robin Ventura, beating the two-time defending American League champion Texas Rangers.
Rios homered off new Rangers closer Joe Nathan (0-1) who got a save with a perfect inning in the season opener a day earlier but entered a tie game this time.
Paul Konerko drove in three runs for the White Sox in his 2,000th career game.
In St. Petersburg, Florida, Luke Scott had three hits and drove in three runs in his debut as Tampa Bay’s designated hitter, helping the Rays beat the New York Yankees.
The Yankees trimmed a six-run deficit to two in the ninth, but Fernando Rodney came out of the bullpen to retire A-Rod on a first-pitch grounder.
Left-hander David Price (1-0) allowed two runs and five hits over 6 1-3 innings to win for the first time since Aug. 28.
In Baltimore, Tommy Hunter took a four-hitter into the eighth inning, Nick Markakis went 3 for 4 with a homer and Baltimore cruised past Minnesota.
Adam Jones and Matt Wieters also homered for the Orioles, who will seek to complete a three-game sweep on Sunday.
After beating the Twins 4-2 on opening day, the Orioles went up 6-0 against Francisco Liriano (0-1) after four innings and coasted to the finish. Markakis homered in a second straight game, Ronny Paulino got four hits and scored twice in his Baltimore debut and Robert Andino contributed two hits and two RBIs.
In Oakland, California, Chone Figgins finished a home run short of the cycle and every Mariners batter had a hit, backing a shaky start from ace Felix Hernandez to beat the Athletics.
Figgins’ two-run double off Bartolo Colon (1-1) highlighted a six-run fourth-inning — helped by a center fielder Yoenis Cespedes misplaying a ball — to give Seattle a 7-0 lead. Ichiro Suzuki also had two hits and an RBI. The Mariners took the season-opening series 3-1 — the first two games were played in Japan.
