England appeared to be in trouble when they lost three wickets in quick succession, but Kevin Pietersen and Eoin Morgan came together for the highest England fourth-wicket partnership in a Twenty20 match, allowing Paul Collingwoods men to reach the target with nine balls to spare.
Morgan was unbeaten on 67, while Pietersen contributed 43 as England scored 130-3.
Earlier, Pakistan extended its poor run with the bat.
A reckless display by the Pakistan batsmen squandered the toss advantage after stand-in captain Shoaib Malik opted to bat. Malik is captain in place of Shahid Afridi who is serving a two-match ban for ball tampering.
Pakistan wickets fell at regular intervals, starting with opener Imran Nazir who pulled a Stuart Broad delivery to Joe Denly at midwicket, to start the slide. Wickets kept falling at regular intervals thereafter. Malik played a steady hand in the middle overs but he too got out to a tame shot in the 15th over to derail any hopes of recovery.
Graeme Swann was the pick of England's bowlers, taking 2-18.
