The deals, signed by Lebanese Prime Minister Saad Hariri with his counterpart in the Syrian capital, were the first since the 2005 assassination in Beirut of his father Rafik Hariri.
The elder Hariri was a member of Parliament and a former premier whose killing heralded international pressure that forced Syria to end its 29-year military presence in Lebanon.
“We want the ties between Syria and Lebanon to form a model for an Arab common market,” Hariri said at a news conference with Syrian Prime Minister Naji Al-Otri.
The agreements included investment protection, pharmaceutical products, shipping, tourism and taxation.
Hariri, who also met President Bashar Assad, said a committee set up by the two countries to demarcate the border "has to begin its work and finish it as soon as possible."
Otri said cooperation between Syria and its smaller neighbor had to extend to security. Damascus had hinted it was concerned about infiltration by militants from Lebanon after a 2008 bombing targeted a security compound in Damascus.
Syrian Foreign Minister Walid Al-Moualem said border demarcation must not cause what he termed social suffering by Syrian families living on Lebanese land and vice-versa.
"The border demarcation issue is not stuck. The two countries have formed committees and are in agreement," he said.
Syria agreed with Lebanon in 2008 to set the border, two years after a United Nations resolution recommended Syria work on the issue. Damascus has since said its technical teams were busy finishing border demarcation with Jordan and that a small Lebanese region occupied by Israel and bordering Syria complicated any demarcation.
A UN investigation into Hariri's killing implicated Lebanese and Syrian security officials. Syria denied any involvement and the younger Hariri has visited Syria several times since he became prime minister last year.
An international tribunal into the killing has yet to indict any suspects. Moualem said if Syrian involvement was proven, the government would try the suspect in Syria for treason.
