WASHINGTON: Anthony Rendon had 10 RBIs, three home runs and six hits as the Washington Nationals took advantage of Noah Syndergaard’s injury and mauled the New York Mets 23-5 on Sunday to set a franchise scoring record.

Rendon went a career-best 6 for 6 and scored five times while breaking the club mark for RBIs. He became the 13th player in major league history to drive in 10 or more runs in a game — the first since Garret Anderson did it for the Angels in 2007.

Matt Wieters added two homers, a single and two walks as the Nationals salvaged the finale of a three-game series between NL East rivals. Adam Lind and Bryce Harper also homered while Harper scored four times to set a major league record for runs in April with 32.

Washington finished with a season-high 23 hits and scored the most runs in the history of the Expos/Nationals franchise. The Nationals’ seven homers were their most since the team moved from Montreal to Washington in 2005.

Rendon, who began the day with no homers and five RBIs this season, raised his batting average from .226 to .278. He capped his incredible performance with a solo home run off Mets backup catcher Kevin Plawecki in the eighth. Harper and Lind went deep against Plawecki earlier in the inning.

It was a miserable day all-around for the Mets, who won the first two games of the series after losing six straight. They gave up 17 consecutive runs after trailing 6-5 in the fourth.

Syndergaard (1-2), the team’s hard-throwing ace, left in the second inning with what the club called “a possible right lat strain” and was on his way back to New York for an MRI on Monday morning.

Red Sox 6 Cubs 2: In Boston, Marco Hernandez scored the go-ahead run on Pedro Strop’s wild pitch in Boston’s four-run eighth inning.

The Red Sox took two of three in the lively weekend series that featured a strong showing for Cubs fans and the World Series trophies that ended long title droughts for the once-frustrated franchises.

Hanley Ramirez hit a two-run homer for Boston and Matt Barnes (3-0) worked one scoreless inning after completing his four-game suspension for throwing behind the head of Baltimore’s Manny Machado.

Kris Bryant hit a solo homer for Chicago, extending his hitting streak to 11 games. Koji Uehara (0-2) got the loss.

Padres 5 Giants 2, 12 innings: In San Francisco, Wil Myers hit a three-run homer in the top of the 12th inning to send San Diego past San Francisco.

Myers’ seventh home run and second in two games came off reliever George Kontos (0-2). Cory Spangenberg singled against Kontos leading off the inning and Erick Aybar singled two batters later.

Hector Sanchez, who played parts of five seasons with the Giants, had a pinch-hit, two-run homer off San Francisco closer Mark Melancon in the ninth to send the game to extra innings. Sanchez’s first home run of the season handed Melancon his second blown save in seven chances.

Sanchez represented the tying run after shortstop Eduardo Nunez booted Luis Sardinas’ leadoff grounder for an error.

Indians 12 Mariners 4: In Cleveland, Michael Brantley homered and Francisco Lindor had a two-run double as Cleveland scored eight times in the third inning against weary Seattle.

Brantley led off the big inning with a single and capped it with a two-run homer. Lindor, who had three RBIs, hit a solo homer in the third and preceded Brantley’s homer with his double.

Josh Tomlin (2-3) allowed four runs in five-plus innings for the win. The Mariners began the sixth with six straight hits and scored three times but Nick Goody worked out of a bases-loaded, none-out jam.

Chase De Jong (0-2), making his first major league start, gave up six runs and nine hits in 2 2/3 innings. Nelson Cruz homered for the Mariners, who finished 4-6 on their 11-day road trip.

Marlins 10 Pirates 3: In Miami, Justin Bour drove in six runs with four hits, both career highs, as Miami rallied from a three-run deficit to end a four-game losing streak by beating Pittsburgh.

Bour had an RBI double in the second, an RBI single in the fourth, a two-run single off Trevor Williams (1-1) in the fifth and a two-run homer in Miami’s six-run seventh.

Josh Bell hit a two-run homer for the Pirates but they were shut out over the final 8 2/3 innings.