EUGENE, Ore.: Marcus Mariota threw for 318 yards and three touchdowns, including a pair to speedy redshirt freshman Devon Allen, and the No. 3 Oregon Ducks’ blur offense prevailed over No. 7 Michigan State’s stout defense, 46-27, on Saturday night.

Mariota’s three touchdown passes in what was considered a premier nonconference matchup gave him 69 for his career, an Oregon record.

After falling behind 27-18 early in the third quarter, Oregon scored four unanswered touchdowns, including on a pair of runs by freshman Royce Freeman, who finished with 89 yards rushing on 13 carries.

The loss snapped an 11-game winning streak for the defending Big Ten and Rose Bowl champion Spartans, who went 13-1 last season. Connor Cook threw for 343 yards, two touchdowns and two interceptions.

No. 14 USC 13 No. 13 Stanford 10: In Stanford, Calif., Andre Heidari kicked a career-long 53-yard field goal with 2:30 left, J.R. Tavai forced a fumble to end Stanford’s comeback bid, and No. 14 Southern California held off the No. 13 Cardinal.

With Stanford threatening to tie or take the lead, Tavai came from Kevin Hogan’s blindside to jar the ball loose. Scott Felix recovered at the 26 with 19 seconds to play, sealing new coach Steve Sarkisian’s first major victory at USC (2-0, 1-0) and upending the two-time defending Pac-12 champions.

Javorius Allen ran for a career-high 154 yards, and Nelson Agholor had a career-high nine receptions for 91 yards to help the Trojans do just enough on offense to win at Stanford Stadium for the first time since 2008.

No. 19 Nebraska 31 McNeese State 24: In Lincoln, Neb., Ameer Abdullah’s 58-yard touchdown dash on a pass from Tommy Armstrong Jr. broke a tie with 20 seconds left in Nebraska’s victory over McNeese State.

McNeese State erased a 10-point deficit to tie it at 24 with 4:21 to play. The Huskers’ winning possession started with 1:14 left, and they were facing third-and-6 when Abdullah made the play of his career.

After catching a pass short of the first-down marker, he first made McNeese State’s Bo Brown miss, then rammed into a pack of three defenders, bounced off Aaron Sam and zoomed past Brent Spikes.

No. 2 Alabama 41 Florida Atlantic 0: In Tuscaloosa, Ala., Blake Sims had 214 passing yards and Jake Coker threw for 202 to lead Alabama past Florida Atlantic in a game halted by lightning.

Both quarterbacks got a chance to stake a claim to the starting job for the Crimson Tide (2-0) in the one-sided game. Both schools agreed to end the game with 7:53 left.

Sims passed for two touchdowns and ran for a third in his second straight start and didn’t play in the fourth quarter. He was 11-of-13 passing.

Coker went 15 of 24 with a touchdown in his first significant action, but the Florida State transfer missed some open receivers downfield.

No. 4 Oklahoma 52 Tulsa 7: In Tulsa, Okla., Sterling Shepard had a career-high 177 yards receiving to help Oklahoma rout Tulsa.

Trevor Knight passed for 299 yards and two touchdowns and ran for another score. Alex Ross ran for 90 yards and a touchdown, Keith Ford rushed for 87 yards and two scores and Blake Bell, a converted quarterback who now plays tight end, caught his first career touchdown pass for the Sooners (2-0).

No. 15 Mississippi 41, Vanderbilt 3: In Nashville, Tenn., Bo Wallace threw for 320 yards and a touchdown, and Mississippi routed Vanderbilt in the Southeastern Conference opener for both teams.

The Rebels (2-0) have beaten Vanderbilt in Nashville in consecutive seasons after the Commodores (0-2) had won five of the previous six.

No. 18 Wisconsin 37 Western Illinois 3: In Madison, Wis., Tanner McEvoy overcame a slow start to throw for three touchdowns and run for another, and Wisconsin pulled to beat Western Illinois.

Melvin Gordon ran for just 38 yards on 17 carries for the Badgers (1-1) with the Fighting Leathernecks (1-1) consistently stacking the box against one of the country’s best rushers. McEvoy shook off a couple bad throws early to finish 23 of 28 for 283 yards with one interception.

No. 20 Kansas State 32, Iowa State 28: In Ames, Iowa, Jake Waters scored on an 8-yard run with 1:30 left to push Kansas State past Iowa State.

Waters threw for 239 yards and ran for a career-high 138 yards for the Wildcats (2-0, 1-0 Big 12). They trailed 28-13 late in the first half.

Jarvis West caught and threw touchdown passes and ran a punt back for a TD for Iowa State (0-2, 0-1).

No. 23 Clemson 73 South Carolina State 7: In Clemson, S.C., Cole Stoudt completed 22 of his 31 passes for 302 yards and Clemson had its highest point total in 33 years.

The Tigers (1-1) gained 735 yards and held the outmatched FCS Bulldogs (1-1) to 44 yards.

The 73 points were the most scored by the Tigers since an 82-24 win over Wake Forest in 1981 and it was their biggest margin since beating Presbyterian 67-0 in 1957. The Tigers are 29-0 against FCS teams.