CLEVELAND: Jose Ramirez was 4-for-4 with a pair of three-run homers for Cleveland, and Detroit Tigers ace Justin Verlander matched a career high by allowing nine runs Saturday in a 13-6 loss to the Indians.

Ramirez had a career-high six RBIs with home runs in the first off Verlander (1-1) and in the eighth against Anibal Sanchez.

Verlander (1-1) gave up 11 hits in four-plus innings, including home runs by Carlos Santana and Lonnie Chisenhall. Santana had three of Cleveland’s 19 hits and four RBIs and Corey Kluber (1-1) struck out eight in 6 1/3 innings, allowing six runs and eight hits.

Mariners 5 Rangers 0: In Seattle, James Paxton extended his season-opening scoreless streak to 21 innings and Taylor Motter hit a three-run homer as Seattle beat Texas.

Paxton (2-0) threw eight innings of two-hit ball, walking one and striking out nine. He has not allowed a run yet in three starts this year, and his scoreless stretch is a team record to open a season. He’s the 10th pitcher in the majors ever to start a year with three scoreless starts of at least six innings.

Twins 6 White Sox 0: In Minneapolis, Ervin Santana (3-0) pitched a one-hitter for the first complete-game victory by a pitcher in MLB this season, stopping Chicago’s three-game winning streak.

Santana’s (3-0) struck out eight, walked one and retired his final 18 batters. Chicago had just two runners: Omar Narvaez singled with one out in the third and Avisail Garcia walked leading off the fourth.

Rockies 5 Giants 0: In San Francisco, Tyler Chatwood (1-2) pitched 5 2/3 perfect innings before Chris Marrero’s single and finished with a two-hitter for his first MLB shutout in Colorado’s win over San Francisco.

Nolan Arenado had three hits, including a home run off Matt Moore (1-2), who allowed five runs, 10 hits and three walks in 5 2/3 innings.

Dodgers 8 Diamondbacks 4: In Los Angeles, Yasiel Puig hit a three-run homer in the eighth inning and Los Angeles overcame a sloppy defensive game to beat Arizona.

Alex Wood (1-0) pitched 3 1/3 scoreless innings of relief to earn the win and Kenley Jansen got the last four outs for his third save.

Yankees 3 Cardinals 2: In New York, St. Louis ace Carlos Martinez (0-2) put on a historically uneven performance, walking a career-high eight while striking out 11 in 5 1/3 innings in the Cardinals’ loss to New York.

Martinez was the first pitcher since Randy Johnson in 1993 with at least eight walks and 11 strikeouts in a game.

The Yankees won their sixth straight despite tying a team record by fanning 17 times. They got plenty of help from sloppy St. Louis, which at 3-8 is off to its worst start in 20 years and has the poorest record in the National League.

Blue Jays 2 Orioles 1: In Toronto, Kendrys Morales homered off Tyler Wilson (1-1) leading off the bottom of the ninth, and Toronto (2-9) stopped a seven-game losing streak.

Roberto Osuna (1-0) had allowed Jonathan Schoop’s sacrifice fly in the top half.

Reds 7 Brewers 5: In Cincinnati, Jesse Winker doubled home the go-ahead run in the sixth off Carlos Torres (0-1) with his first MLB hit, and Cincinnati overcame two more homers by Eric Thames and stopped Milwaukee’s four-game winning streak.

Reds left-hander Brandon Finnegan came out of the game after the first inning because of a strained muscle in the back of his left side. The Reds already have three starters on the disabled list.

Raisel Iglesias (1-0) allowed one run in two innings as manager Bryan Price used five relievers after Finnegan’s early departure. Michael Lorenzen walked a batter in the ninth while getting his first career save.