• Political hot air

Pushed back against Republican critics who sketch a gloomy picture of an America in economic decline and weakened on the world stage. “All the talk of America’s economic decline is political hot air. Well, so is all the rhetoric you hear about our enemies getting stronger and America getting weaker. The United States of America is the most powerful nation on Earth. Period. It’s not even close.”

• Fix our politics

Said a future of peace, prosperity and opportunity is only attainable “if we fix our politics.” Specific problem areas identified by Obama: Reducing barriers to voting, limiting the influence of money in politics, ending the drawing of congressional districts to benefit politicians’ interests.

• 2016 campaign

Took indirect swipes at Republican presidential candidates for bluster on fighting terrorism. “Our answer needs to be more than tough talk or calls to carpet bomb civilians. That may work as a TV sound bite, but it doesn’t pass muster on the world stage.”

• Obama’s regret

Owned up to one regret in an otherwise optimistic address: That average people feel the system is rigged “in favor of the rich or the powerful or some narrow interest.” Pledged to keep working on that “so long as I hold this office.”

• Cancer ‘moon shot’

Likened administration’s push against cancer to a new “moon shot.” Assigned Vice President Joe Biden to lead a new push to fight cancer, building on a large increase in federal financing for the National Institutes of Health. “Let’s make America the country that cures cancer once and for all.” Biden’s son, Beau Biden, died of cancer last year.

• Common ground

Identified a number of areas where Democrats and Republicans might be able to find common ground: pursuing criminal justice reform, promoting trade, fighting opioid abuse. Made an overture to new House Speaker Paul Ryan by highlighting his interest in fighting poverty. “I’d welcome a serious discussion about strategies we can all support, like expanding tax cuts for low-income workers without kids.”

• Killers and fanatics

Promised resolve in fighting terrorism and the Daesh group, but dismissed “over-the-top claims that this is WW-III.” Rejected the idea that Daesh threatens “our national existence.” “We just need to call them what they are — killers and fanatics who have to be rooted out, hunted down and destroyed.”

• You’ll be pretty lonely’

Predicted those who dispute the science of climate change will end up “pretty lonely.” Promoted his efforts to fight global warming and said those who doubt it is happening are welcome to “have at it.”