Nava, a switch-hitter best known for hitting a grand slam on the first major league pitch he saw on June 12, batted for Eric Patterson when lefty Will Ohman replaced Brad Bergesen (3-5) with two outs and Marco Scutaro on second with a double.
Nava popped a 2-1 pitch down the line and Scutaro scored easily.
Tim Wakefield (3-6) got the win, allowed two runs and seven hits in eight innings for his second win in his last six decisions.
Jonathan Papelbon had two strikeouts in a perfect ninth inning for his 19th save in 22 opportunities.
J.D. Drew hit two solo homers for the Red Sox.
Before the game, the Red Sox placed catcher Jason Varitek and reliever Manny Delcarmen on the disabled list. There are 10 Red Sox on it, including Josh Beckett, Dustin Pedroia and Victor Martinez.
The Orioles lost for the third time in eight games but scored three runs or less for the 45th time in their 79 games.
At New York, Alex Gonzalez hit a go-ahead single in the 11th inning and Toronto snapped a five-game losing streak.
Gonzalez singled for a 2-1 lead and Dewayne Wise’s bases-loaded triple capped a five-run burst for the Blue Jays.
Lyle Overbay and John Buck opened the Toronto 11th with singles. A sacrifice and an intentional walk loaded the bases for Gonzalez, who lined his single over leaping third baseman Alex Rodriguez. After another out, Vernon Wells walked and Wise tripled.
Jason Frasor (3-1) pitched the 10th for the win. David Robertson (0-3) took the loss.
The Blue Jays tied it at 1 in the eighth on Aaron Hill’s RBI single with two outs off Joba Chamberlain.
At Detroit, Max Scherzer allowed three hits in a season-high eight innings and late substitute Don Kelly got Detroit’s offense going.
Johnny Damon hit a two-run homer and the Tigers opened their homestand with a win despite playing without star slugger Miguel Cabrera, a late scratch from the lineup due to lower back pain. Cabrera began the day tied for the major league lead with 20 homers and 68 RBIs.
Kelly, filling in at first base for Cabrera, doubled in Detroit’s first two runs in the second and Austin Jackson followed with a two-run single. Brennan Boesch added an RBI single in the fifth to chase Mariners starter Doug Fister (3-4), and Damon hit his fourth homer of the season off Sean White in the seventh.
Scherzer (5-6) struck out seven and walked two. The only run he allowed came on Franklin Gutierrez’s homer in the second.
At Cleveland, Gio Gonzalez pitched five-hit ball into the seventh inning and Mark Ellis drove in two runs with a bases-loaded double for Oakland.
The loss snapped Cleveland’s season-high five-game winning streak. Oakland has won six of seven.
Gonzalez (7-5), who won for the first time since June 6, walked four and struck out five in 6 2-3 innings. The left-hander has beaten Cleveland twice this season, holding the Indians scoreless for 13 2-3 innings. He’s 3-0 in four starts against Cleveland since 2009.
Andrew Bailey pitched the ninth for his 16th save in 19 opportunities.
At Minneapolis, Danny Valencia had two hits and the go-ahead RBI in the seventh inning and Minnesota outlasted David Price and Tampa Bay.
Scott Baker (7-7) gave up one run and six hits and struck out eight in seven innings.
Price (11-4), who entered the game leading the AL in wins and ERA, allowed two runs and four hits with six strikeouts in eight innings. The Twins tagged him for two runs in the seventh and Jon Rauch stranded the tying run at second base for his 18th save in 22 chances.
Price had a one-hitter going with two outs in the seventh before the Twins put together three straight hits.
At Arlington, Mark Kotsay hit a two-out, two-run double in the ninth inning and Chicago prevailed in a game that started about 2 1/2 hours late because of rain.
After Paul Konerko reached on a fielder’s choice, Brent Lillibridge came on as a pinch-runner and moved up when Carlos Quentin got hit on the arm by a 97 mph fastball from Neftali Feliz (1-2). Kotsay then hit a sinking liner to left that ricocheted off the glove of a diving Josh Hamilton for Chicago’s only extra-base hit.
J.J. Putz (5-2) worked a scoreless inning before Matt Thornton pitched the ninth for his fourth save.
At Anaheim, California, Mike Aviles doubled home the tying run in the ninth inning and Willie Bloomquist had an RBI single in the 10th to lift Kansas City.
Bloomquist, who entered the game as a pinch-runner in the ninth and scored the tying run, lined a 1-2 pitch from Scot Shields to left field after a two-out intentional walk to David DeJesus(notes). The hit scored Yuniesky Betancourt, who led off the inning with a single against Shields (0-3).
Robinson Tejeda (3-3) got one out for the win and Joakim Soria three outs for his 21st save in 22 chances.
Joe Saunders took a six-hit shutuout into the ninth, but issued a leadoff walk to Billy Butler and was pulled after 111 pitches. Down to their last strike, the Royals tied it when Aviles drove a 2-2 pitch from closer Brian Fuentes to center field for a double that scored Bloomquist.
