Tulowitzki hit a two-run homer in the first inning, doubled in the third and added another two-run homer in the fifth against rookie John Ely (4-8). Tulowitzki fouled out with the bases loaded in the eighth, but Melvin Mora hit a grand slam later in the inning.
Tulowitzki joined Albert Belle (1995) and Barry Bonds (2001) as the only players since 1900 to homer 14 times in a span of 15 games.
Jhoulys Chacin (9-9) threw 111 pitches over eight innings and was pulled three outs shy of his first big league shutout and complete game.
In San Francisco, Yovani Gallardo struck out six in seven innings and Milwaukee knocked the Giants out of first place in the NL West.
San Francisco fell a half-game back of San Diego after the Padres won 8-4 at St. Louis. San Francisco dropped two games behind Atlanta in the NL wild-card race.
Jonathan Lucroy hit a two-run single in the fourth inning that held up for Gallardo (13-7). The right-hander matched his career high for wins also done last year. Gallardo out pitched Tim Lincecum (14-10).
Giants manager Bruce Bochy pulled his ace after five innings and a season-low 72 pitches. San Francisco trailed 2-0 when Lincecum left.
In Houston, Jay Bruce , Jim Edmonds and Drew Stubbs hit home runs and Cincinnati beat the Astros to increase their lead in the NL Central.
The Reds opened a seven-game edge over second-place St. Louis. Cincinnati stopped a six-game road losing streak.
Bronson Arroyo (16-10) pitched four-hit ball for six innings, striking out five and walking one.
Bruce's two-run homer highlighted a four-run fifth as the Reds took a 7-1 lead. Joey Votto started the inning with a double and Bruce connected one out later off Nelson Figueroa (5-3) for his 21st home run.
In Philadelphia, Ryan Howard hit a two-run homer to lead the Phillies to their sixth straight victory.
Jayson Werth and Raul Ibanez also homered for Philadelphia, which maintained a three-game lead over the Atlanta Braves in the NL East.
Howard's drive in the third gave him his fifth straight seasons with at least 30 homers and 100 RBIs, setting a new franchise record previously held by Hall of Famer Chuck Klein.
Kyle Kendrick (10-9) gave up two runs and six hits in six innings. He struck out three and walked one.
Washington right-hander Jordan Zimmerman (0-2), making his fifth start of the season after undergoing Tommy John surgery last August, allowed six runs on nine hits in three innings.
In New York, Tim Hudson snapped a three-start losing streak and Nate McLouth homered and drove in two runs, giving Atlanta's playoff push another boost.
Holding a two-game in the NL wild-card race, the Braves got a two-run double from Alex Gonzalez and won their second straight game at Citi Field.
Billy Wagner struck out all three batters in the ninth against his former team for his second save of the series and 35th this year.
Hudson (16-8) allowed solo homers to Jose Reyes and Luis Hernandez , who connected one pitch after breaking a bone in his right foot on a foul ball.
McLouth hit a run-scoring double in the second off rookie Dillon Gee (1-1) and a solo shot in the ninth against Bobby Parnell .
In St. Louis, Ryan Ludwick snapped a ninth-inning tie with a three-run homer, helping San Diego beat his old team and end an 11-game losing streak in St. Louis.
Will Venable and David Eckstein had three hits and an RBI apiece for the Padres, who snapped a three-game skid overall and moved back into first the NL West when San Francisco lost to Milwaukee.
Ludwick and Matt Stairs hit back-to-back homers off Kyle McClellan (1-4).
Mike Adams (4-1) was the winner.
In Miami, Marlon Byrd drove in two runs, Casey Coleman pitched six solid innings and the Cubs won their season-high fifth straight.
Aramis Ramirez and Blake DeWitt also drove in a run for the Cubs.
Carlos Marmol pitched a scoreless ninth to earn his 33rd save in 38 opportunities.
Marlins rookie Logan Morrison had three hits to extend his streak of reaching base to 37 games, tying Cliff Floyd for the third-longest string in franchise history.
Coleman (2-2) allowed three runs and five hits. He struck out five and walked four.
Anibal Sanchez (12-10) was lifted after the fifth. He allowed four runs.
In Pittisburgh, John Bowker and Andrew McCutchen each hit two-run homers, James McDonald extended his scoreless-innings streak to 20 innings before giving up two runs and Pittsburgh beat Arizona.
Ryan Church hit a three-run homer and Kelly Johnson also connected for Arizona, which has lost 11 of 14 and assured itself of its second consecutive last-place finish in the NL West.
McDonald (4-5) improved to 4-1 at home with Pittsburgh and 4-4 overall since joining the Pirates in a trade with the Dodgers.
